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Praziquantel was evaluated for its larvicidal activity against naturally or experimentally induced Taenia hydatigena infections in sheep. The major criterion used for assessing efficacy was an estimate of the dose rate required to free 90 per cent of the sheep from infection (ED90) together with a 95 per cent confidence interval. With both light and heavy infections of three-month-old T hydatigena in lambs up to 12 months old, many larvae were killed. The ED90 and 95 per cent confidence limits for six-month-old and aged organisms was estimated to be 13.1 (5.5 to 31.4) mg/kg and 6.1 (2.4 to 15.5) mg/kg, respectively. Equivalent data for the ED50 were 3.4 (1.4 to 8.3) mg/kg and 1.3 (0.3 to 5.4) mg/kg, respectively. It was established that one of the factors involved in the efficacy of praziquantel was associated with the age of the larvae at the time of treatment, the drug being markedly more effective against older than younger organisms. 相似文献
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Tablets containing praziquantel, pyrantel embonate, and febantel were tested for efficacy against helminths in dogs. A single treatment with this drug combination gave 100% reductions in Toxocara canis and Taenia hydatigena in experimentally induced infections in dogs. In dogs with naturally acquired infections, treatment gave > 97 to 98% reductions in fecal egg counts attributable to Toxascaris leonina, T canis, and Uncinaria stenocephala. Efficacy against Trichuris vulpis was > 92%. 相似文献
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Abstract Extract Theoretically, the life-cycle of the sheep metacestodes with their strobilate phase in dogs permits combinations of at least three methods of control. These are the prevention of dogs gaining access to larval cestodes, the chemical elimination of the strobilate and or the larval stage in the appropiate hosts, and the immunization of either the definitive or intermediate hosts or both. The first approach using arecoline hydrobromide primarilv as a diagnostic agent has reduced the prevalence of Echinococcus granulosus (Gemmell, 1968). However, it did not markedly reduce the prevalence rate of Taenia hydatigena and may have been indirectly associated with an increase in that of Taenia ovis. 相似文献
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