Air Pollution and Medical Research     

Goldsmith JR 《Science (New York, N.Y.)》1963,141(3583):832-834

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Women in science: symposium and job mart     

Goldsmith NF 《Science (New York, N.Y.)》1970,168(3935):1124-1127

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Pharmacokinetics of sulfamethazine in male, female and castrated male swine   总被引：1，自引：0，他引：1  

NICOLE E. DUFFEE  RICHARD F. BEVILL  JOHN C. THURMON  HERBERT G. LUTHER  JR    DALE E. NELSON  FRANCES E. HACKER 《Journal of veterinary pharmacology and therapeutics》1984,7(3):203-211

The concentration of sulfamethazine in plasma and sulfamethazine and its metabolites in urine were compared in male, female and castrated male swine. A surgical technique for placement of catheters in the urinary bladder was used to facilitate the collection of urine in males and castrated males. The elimination rate of sulfamethazine from plasma and the excretion of parent drug and metabolites into urine did not differ significantly among females, males and castrated male swine.  相似文献   

Soil and agronomic factors associated with cadmium accumulations in kidneys of grazing sheep     

PW MORCOMBE  DS PETTERSON  PJ ROSS†  JR EDWARDS 《Australian veterinary journal》1994,71(12):404-406

SUMMARY Mean concentration of cadmium (Cd) in kidneys of hogget sheep from 67 flocks grazing in the Agricultural Region of Western Australia was tested for association with soil, pastoral, climatic and nutritional factors. Hoggets grazing pastures on acidic soils and soils with a sandy-textured surface had higher Cd concentrations in kidneys than hoggets grazing pastures on more alkaline soils or soils with a clay-textured surface. Application of more than 100 kg of phosphatic fertiliser during the past 3 years to loamy soils was also associated with greater Cd concentration in kidneys of the grazing animals.  相似文献   

Control of equine infectious anaemia on a large northern Queensland farm     

JR. ARMSTRONG  ID. BRAITHWAITE  M. FLANAGAN  D. HOFFMANN  I. POLKINGHORN 《Australian veterinary journal》1989,66(1):29-30

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Parasitic health of olive baboons in Bwindi Impenetrable National Park, Uganda     

Hope K  Goldsmith ML  Graczyk T 《Veterinary parasitology》2004,122(2):165-170

This study examined the endoparasite load of a group of olive baboons (Papio cynocephalus anubis) that share their habitat with a population of mountain gorillas (Gorilla gorilla berengei) in Bwindi Impenetrable National Park, Uganda. During a 2-week period in June 2002, shared habitat was substantiated by noting the ranging patterns of both species and recording observations and trail remains with a global positioning system (GPS). Parasite load was determined by collecting fecal samples preserved in 10% formalin and analyzed by sedimentation techniques and immunofluorescent antibodies (IFA). Bwindi baboons were infected with Cryptosporidium, Giardia, Eimeria, Ascaris spp., Strongyloides spp., Trichuris spp., Hymenolepis spp., and Ternidens diminuta. Of these, the Bwindi mountain gorillas had previously been found to carry Cryptosporidium, Giardia, Strongyloides spp., and Trichuris spp., but not Eimeria, Ascaris, Hymenolepis, or T. diminuta. This study is the first to record Giardia in olive baboons and demonstrates that at least three parasite species in Bwindi baboons have yet to be found in Bwindi gorillas. Early monitoring is essential to the health and well being of both of these sympatric primate species, especially as they continue to interact more often and over a larger area.  相似文献   

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation     

Mukherjee S  Keitany G  Li Y  Wang Y  Ball HL  Goldsmith EJ  Orth K 《Science (New York, N.Y.)》2006,312(5777):1211-1214

Yersinia species use a variety of type III effector proteins to target eukaryotic signaling systems. The effector YopJ inhibits mitogen-activated protein kinase (MAPK) and the nuclear factor kappaB (NFkappaB) signaling pathways used in innate immune response by preventing activation of the family of MAPK kinases (MAPKK). We show that YopJ acted as an acetyltransferase, using acetyl-coenzyme A (CoA) to modify the critical serine and threonine residues in the activation loop of MAPKK6 and thereby blocking phosphorylation. The acetylation on MAPKK6 directly competed with phosphorylation, preventing activation of the modified protein. This covalent modification may be used as a general regulatory mechanism in biological signaling.  相似文献   

Distribution and temporal prevalence of Theileria orientalis major piroplasm surface protein types in eastern Australian cattle herds     

GJ Eamens  G Bailey  JR Gonsalves  C Jenkins 《Australian veterinary journal》2013,91(8):332-340

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The Use of Colonic Irrigation to Control Fecal Incontinence in Dogs With Colostomies     

Fred A. Williams  JR  DVM  Ronald M. Bright  DVM  MS  Diplomate ACVS    Gregory B. Daniel  DVM  MS  Diplomate ACVR    Kevin A. Hahn  DVM  PhD    Steve A. Patton  DVM  MS  Diplomate ACVP 《Veterinary surgery : VS》1999,28(5):348-354

OBJECTIVE: To determine if once-daily colonic irrigation results in fecal continence for a 24-hour period in dogs with colostomies and if colonic volume increased in response to the irrigation. STUDY DESIGN: A prospective controlled experimental study. ANIMALS: Four intact male and one intact female mixed breed dogs. MATERIALS: All dogs received left end-on paralumbar colostomies. Four dogs received once-daily colonic irrigation for 8 weeks, whereas the control dog did not. Daily fecal weights were recorded for the length of the study in all dogs. Barium enema studies and volumetric studies were used to determine colonic volumes. RESULTS: Daily fecal weights were significantly decreased in treatment dogs compared with the control dog. Colonic volume increased in irrigated dogs in response to daily irrigation over the 8 week period of the study. CONCLUSIONS: Colonic irrigation resulted in significantly decreased fecal production over a 24-hour period. Therefore management of dogs with colostomies would be more practical and cost effective. It did not result in complete fecal continence in this study. Further clinical studies are indicated to determine if longer periods of irrigation would result in complete continence.  相似文献   

The dietary regime of detritivorous fish from the River Jacaré Pepira, Brazil     

M. M. Vaz  M. Petrere JR  L. A. Martinelli  A. A. Mozeto 《Fisheries Management and Ecology》1999,6(2):121-132

The diet of detritivorous fish was analysed at four distinct habitats in a tropical river during the wet and dry seasons. Two methodologies were used to determine the diet of the fish: (1) the direct analysis of the stomach contents; and (2) the use of stable carbon isotopes. Both methods indicated food partitioning among the fish. The stomach contents showed what the fish had ingested when captured and the ¹³C isotope indicated what it had assimilated over a long period of time. The ¹³C isotope suggested the existence of sectional differences in the feeding of the detritivorous fish along the river. Plants employing the C₄ photosynthesis pathways seem to have little influence on the diet of these fish. This method proved to be more appropriate for the detection of the main food sources of the captured fish.  相似文献