CRETINISM IN A NORTH AMERICAN BLACK BEAR(URSUS AMERICANUS)     

Robert B.  Duncan  JR DVM  PHD  Jeryl C.  Jones  DVM  PHD  H. David Moll    DVM  MS  Martha M.  Moon  DVM  MS  Dennis J.  Blodgett  DVM  PHD  Michael R.  Vaughan  PHD 《Veterinary radiology & ultrasound》2002,43(1):31-36

Congenital hyperplastic goiter and cretinism were documented in a 16 month-old male North American black bear (Ursus americanus). The cub was captured at approximately 8 months of age and maintained for an additional 8 months in captivity. Clinical signs included growth retardation, clumsiness, and facial dysmorphism. Hypothyroidism was documented by determining serum triiodothyronine (T3) and thyroxine (T4) levels. Lysosomal storage disease was ruled out by measuring various lysosomal enzyme activities. Serologic, radiographic, computed tomographic, necropsy, and histopathologic findings were consistent with congenital hypothyroidism and cretinism.  相似文献   

The Effects of Atropine and Glycopyrrolate on Heart Rates in Conscious Mature Goats     

LUISITO S. PABLO DVM  MS  Diplomate ACVA    ALISTAIR I. WEBB BVSC  PhD  FRCVS  Diplomate ACVA  WALTER T. McNICHOLAS JR  DVM 《Veterinary surgery : VS》1995,24(6):531-534

The effects of intravenously administered atropine (0.2 mg/kg) and glycopyrrolate (0.01 mg/kg) on heart rate were studied in 10 conscious mature goats. In a drug cross-over fashion, either atropine, glycopyrrolate, or 0.9% saline solution was administered using the same volume (0.05 mL/kg). Atropine and glycopyrrolate caused a significant increase in heart rate ( P <.05), whereas saline solution (0.09%) did not. The mean percent changes in heart rate from baseline were similar for atropine and glycopyrrolate up to 14 minutes after administration. Thereafter, glycopyrrolate had a significantly greater mean change in heart rate than atropine, ie, up to 29 minutes ( P <.05). Within the atropine group, the mean percentage changes in heart rate became significantly lower compared with the initial increase (1 minute) starting at 11 minutes. For the glycopyrrolate group, the mean percent changes became significantly lower starting at 27 minutes. Glycopyrrolate and atropine had a mean percentage change in heart rate of greater than 1.0%, up to 31 and 22 minutes, respectively. At the doses used, glycopyrrolate had longer duration of action than atropine but the magnitude of increase was similar.  相似文献   

Sudden blindness associated with protothecosis in a dog   总被引：1，自引：0，他引：1  

JR BLOGG  JE SYKES† 《Australian veterinary journal》1995,72(4):147-149

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Figurate Erythema Resembling Erythema Annulare Centrifugum in a Ferret with Adrenocortical Adenocarcinoma-associated Alopecia     

DANNY W. SCOTT  WILLARD J. GOULD  SUZANNE M. CAYATTE  HOWARD J. LAWRENCE  WILLIAM H. MILLER JR. 《Veterinary dermatology》1994,5(3):111-115

Resumen— Describimos un caso de alopecia simétrica bilateral en un hurón hembra esterilizada de 3 años. El cuadro resultó estar asociado con un adenocarcinoma adrenocortical y con concentraciones séricas elevadas de estradiol. Además el animal presentaba eritema figurado en la zona dorsolateral, lumbosacra y en la cola con caracteristicas clinicas e histopatológicas parecidas al eritema annulare centrifugum de la especie humana. El eritema figurado se trató con éxito con un producto comercial que contiene el ácido graso omega-3/omega-6. [Scott D. W., Gould, J. W., Cayatte, S. M., Lawrence, H. J., Miller, W. H., Jr. Figurate erythema resembling erythema annulare centrifugum in a ferret with adrenocortical adenocar-cinoma-associated alopecia (Eritema figurado parecido a eritema anulare centrifugum en un hurón con alopecia asociada a un adenocarcinoma adrenocortical).
Abstract— Bilaterally symmetric alopecia and vulvar enlargement is reported in a 3-year-old, spayed female ferret. The condition was ultimately shown to be associated with an adrenocortical adenocarcinoma and elevated serum estradiol concentrations. In addition, the ferret had a figurate erythema over the dorsolateral lumbosacral region and tail that was clinically and histopathologically similar to erythema annulare centrifugum in humans. The figurate erythema was successfully treated with a commercial omega-3/omega-6 fatty acid-containing product.  相似文献   

The effects of antigenic competition on the efficacy of multivalent footrot vaccines     

CL SCHWARTZKOFF  JR EGERTON†  DJ STEWART‡  PR LEHRBACH§  TC ELLEMAN¶  PA HOYNE¶ 《Australian veterinary journal》1993,70(4):123-126

SUMMARY A multivalent footrot vaccine has been developed, containing pilus antigens produced in recombinant Pseudomonas aeruginosa and representing all nine serogroups of Dichelobacter (Bacteroides) nodosus commonly recognised in the field. The responses of sheep to the multivalent vaccine have been compared with those to monovalent vaccines representing only a single serogroup. Antigenie competition between serogroups occurred in sheep immunised with the multivalent formulation, but high levels of protection were still achieved. The study showed that in multivalent footrot vaccines, antigenic competition is predominantly due to the presence of a family of immunologically-related pilus antigens rather than to interference by extraneous proteins.  相似文献   

Pharmacokinetics of cephalexin in cats after oral administration of the antibiotic in tablet and paste preparations   总被引：2，自引：0，他引：2  

JR THORNTON  PJ MARTIN 《Australian veterinary journal》1997,75(6):439-440

Objective To determine the bioequivalence of a paste formulation of cephalexin with that of the tablet form.
Design A two-way cross-over study.
Animals Ten adult cats of mixed breed.
Procedure The cats, randomly allocated to two groups, received either the paste preparation or the tablet orally at 12-hour intervals for 48 h before a 12-hour blood collection period. Two weeks later the treatments were reversed and the blood sampling repeated. The serum concentrations of the antibiotic were determined. The pharmacokinetic factors were analysed using a computer.
Results There were no significant differences between the peak concentration of cephalexin, or the other pharmacokinetic factors obtained from the tablet and paste formulations. The serum profiles of cephalexin following four 12-hourly doses of each formulation were similar with the peak serum values occurring at approximately 2 h after administration.
Conclusion The paste formulation and the tablet form are bioequivalent.  相似文献   

Bilateral hypoplasia of the soft palate in a foal     

CB RILEY  JV YOVICH  JR BOLTON 《Australian veterinary journal》1991,68(5):178-179

Bilateral hypoplasia of the soft palate and aspiration pneumonia occurred in a Standardbred foal. The filly was presented with a history of illthrift, dyspnoea, coughing and bilateral nasal discharge. Abnormal sounds (crackels and wheezes) were auscultated over all lung fields and the cervical trachea. Endoscopy revealed a shortened soft palate with a uvula-like mass protruding from the free border into the nasopharynx. Mucopurulent material was present in the trachea. Samples obtained by tracheal wash were submitted for cytology, culture and sensitivity testing. Results indicated a septic inflammatory process. On lateral radiographs of the thorax there were patchy areas of consolidation and air bronchograms. The foal was euthanased. Necropsy confirmed the presence of a palatal defect and aspiration pneumonia of moderate severity. No other congenital abnormalities were present.  相似文献   

Immunological detection of cardiac glycosides in plants     

DJ RADFORD  K. CHEUNG  R. URECH  JR GOLLOGLY  P. DUFFY 《Australian veterinary journal》1994,71(8):236-238

Summary Australian native and introduced plants were examined, using digoxin immunoassays, to detect the presence of cross-reacting cardiac glycosides. These compounds were found in 27 species from 20 genera. The assay technique can also be used on serum samples to confirm cardiac glycoside ingestion.  相似文献   

Pharmacokinetics of gentamicin after intravenous and subcutaneous injection in obese cats   总被引：2，自引：0，他引：2  

L. C. WRIGHT  C. R. HORTON  JR.    A. D. JERNIGAN  R. C. WILSON  C. H. CLARK 《Journal of veterinary pharmacology and therapeutics》1991,14(1):96-100

Six adult domestic shorthair obese cats were given 3-mg/kg gentamicin sulfate by rapid i.v. and by s.c. injection in a cross-over design. The plasma concentration-time data were analyzed using statistical moment theory with no assumption of a specific compartmental model. Means +/- SD for the half-life, which was calculated from the terminal slope of the log concentration-time curve, were 1.37 +/- 0.24 and 1.24 +/- 0.22 h following i.v. and s.c. injection, respectively. The apparent volume of distribution at steady state was 118.55 +/- 19.83 ml/kg, and total body clearance was 1.07 +/- 0.25 ml/kg/min. Bioavailability was 83.58 +/- 14.83% after s.c. administration. The calculated s.c. dose in obese cats to produce an average steady-state concentration of 4 micrograms/ml is 2.5 mg/kg every 8 h compared to 3 mg/kg in normal-weight cats.  相似文献   

Community-associated MRSA SCCmec type IVd in Irish equids     

Maeda Y  Millar BC  Loughrey A  Goldsmith CE  Rooney PJ  Moore JE  Rao J  Buckley T  Egan C  Dooley JS  Lowery CJ  Matsuda M 《The Veterinary record》2007,161(1):35-36

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