Prevalence and distribution of paratuberculosis (Johne's disease) in cattle herds in Ireland     

Good M  Clegg T  Sheridan H  Yearsely D  O'Brien T  Egan J  Mullowney P 《Irish veterinary journal》2009,62(9):597-606

A simple random survey was conducted in Ireland during 2005 to estimate the ELISA-prevalence of paratuberculosis, commonly called Johne's disease (JD), in the cattle population. Serum samples were collected from all 20,322 females/breeding bulls over 12 months-of-age in 639 herds. All samples were tested using a commercially available absorbed ELISA. The overall prevalence of infected herds, based on the presence of at least one ELISA-positive animal, was 21.4% (95% CI 18.4%-24.9%). Herd prevalence levels amongst dairy herds (mean 31.5%; 95% CI: 24.6%, 39.3%) was higher than among beef herds (mean 17.9%; 95% CI: 14.6%-21.8%). However, the animal level prevalence was similar. The true prevalence among all animals tested, was calculated to be 2.86% (95%CI: 2.76, 2.97) and for animals >= 2 yrs, it was 3.30% (95%CI: 3.17, 3.43). For animals in beef herds, true prevalence was 3.09% (95%CI: 2.93, 3.24), and for those in dairy herds, 2.74% (95%CI: 2.59, 2.90). The majority of herds had only one ELISA-positive infected animal. Only 6.4% (95% CI 4.7%-8.7%) of all herds had more than one ELISA-positive infected animal; 13.3% (CI 8.7%-19.7%) of dairy herds ranging from two to eight ELISA-positive infected animals; and, 3.9% beef herds (CI 2.4%-6.2%) ranging from two to five ELISA-positive infected animals. The true prevalence of herds infected and shedding Mycobacterium avium subspecies paratuberculosis is estimated to be 9.5% for all herd types; 20.6% for dairy herds; and 7.6% for beef herds. If ELISA positive animals <2-years-of-age are excluded, the true herd prevalene reduces to: 9.3% for all herd types; 19.6% for dairy herds; and 6.3% for beef herds based on a test specificity (Sp) of 99.8% and test sensitivity (Se) (i.e., ability to detect culture-positive, infected animals shedding at any level) of 27.8-28.9%.  相似文献   

What is your diagnosis? Rodenticide poisoning     

Good KL  Newell SM  Cooke KL 《The Journal of small animal practice》1999,40(10):464, 502-464, 503

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Anesthesia case of the month. Partial obstruction of the trachea was a differential diagnosis for the bird's respiratory problems.     

D A Good  J J Heatley  T N Tully  J A Smith 《Journal of the American Veterinary Medical Association》2001,219(11):1529-1531

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Analysis of post-partum fertility in mares on a Thoroughbred stud in southern Victoria     

TC LOWIS  JH HYLAND† 《Australian veterinary journal》1991,68(9):304-306

This project surveys the reproductive performance of 154 foaling Thoroughbred mares on a commercial stud in southern Victoria. Of these, 96 were served on foal heat (FHS) and 58 were served at a subsequent prostaglandin-induced oestrus (PGS). The PGS group of mares performed more favourably in all aspects except the foaling-to-conception interval where there was a 9.4 day advantage to the FHS group. The first service conception rate in the FHS group was 47.9% compared with 55.2% in PGS mares. Second heat period conception rates were 46% vs 57.7% for FHS and PGS mares, respectively. Overall conception rates at the end of the breeding season were 83.3% in the FHS group and 89.7% in the PGS group. Pregnancy losses before day 45 and after day 45 were 10% and 9.3% in FHS mares and 3.9% and 3.6% in the PGS mares. Served oestrous periods per conception numbered 1.7 and 1.4 in the FHS and PGS groups, respectively.  相似文献   

Chediak-Higashi syndrome: hereditary gigantism of cytoplasmic organelles   总被引：6，自引：0，他引：6  

D B Windhorst  A S Zelickson  R A Good 《Science (New York, N.Y.)》1966,151(706):81-83

In the Chediak-Higashi syndrome, an anomalous hypopigmentation is associated with large lysosomal granules in the blood leukocytes. Since the inheritance pattern is that of an autosomal recessive trait, we postulated a common mechanism for these two primary features of the disease. Electron microscopy of melanocytes revealed that the pigmentary anomaly is indeed based on giant melanosomes. Since both types of granules, leukocytic and melanosomal, are characterized by limiting membranes, Chediak-Higashi disease may be a genetic disease of membranes.  相似文献   

An effective anthelmintic in treatment of quail infected with Capillaria contorta     

R B Davis  R E Good  J T Tumlin  J Brown 《Avian diseases》1969,13(3):690-691

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Unilateral intraocular mastocytosis and anterior uveitis in a dog with subcutaneous mast cell tumors     

Brendan O. Boostrom  Kathryn L. Good  David J. Maggs  Robert B. Rebhun  Jennifer L. Johns  Michael S. Kent 《Veterinary ophthalmology》2014,17(2):131-138

A 9‐year‐old male castrated Scottish terrier was referred to the Radiation Oncology Service at the William R. Pritchard Veterinary Medical Teaching Hospital for palliative radiation therapy of an incompletely excised, recurrent subcutaneous mast cell tumor (MCT) located over the right scapula, and surgical removal of a perianal MCT. Three weeks after initial presentation and prior to the fifth radiation treatment, the patient was presented with cloudiness of the left eye of 3–7 days duration. Ophthalmic consultation revealed 3+ aqueous flare with a dependent, swirling component filling approximately one‐third of the anterior chamber. Aqueocentesis was performed under general anesthesia. Cytology revealed mast cells with highly atypical morphology and considered most consistent with neoplasia. The patient died 7 months after pathologic diagnosis of MCT on the right shoulder and 2 months after the cytologic diagnosis of malignant mast cells in the left anterior chamber. To the authors' knowledge, this is the first report of intraocular involvement in a mammal with MCTs, described here as intraocular mastocytosis.  相似文献   

Targeting malaria virulence and remodeling proteins to the host erythrocyte     

Marti M  Good RT  Rug M  Knuepfer E  Cowman AF 《Science (New York, N.Y.)》2004,306(5703):1930-1933

To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to approximately 8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.  相似文献   

"The big trouble with scientific writing . . ."     

Good RH 《Science (New York, N.Y.)》1967,157(3795):1374-1376

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Nucleolar clustering of dispersed tRNA genes     

Thompson M  Haeusler RA  Good PD  Engelke DR 《Science (New York, N.Y.)》2003,302(5649):1399-1401

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