Susceptibility of canine and feline Escherichia coli and canine Staphylococcus intermedius isolates to fluoroquinolones     

Gottlieb S  Wigney DI  Martin PA  Norris JM  Malik R  Govendir M 《Australian veterinary journal》2008,86(4):147-152

OBJECTIVES AND DESIGN: 1) A prospective study to determine in vitro concentrations for a range of fluoroquinolones, gentamicin and amoxycillin-clavulanate required to inhibit growth of recently collected, feline and canine Escherichia coli and canine Staphylococcus intermedius isolates. 2) A comparative retrospective study to compare the minimum inhibitory concentrations (MICs) of ciprofloxacin, enrofloxacin and amoxycillin-clavulanate for archived canine E coli and S intermedius isolates collected ten to twenty years earlier, with those for recently collected isolates. PROCEDURE: Susceptibility was assessed using disk diffusion, agar dilution susceptibility testing and Epsilometer tests (E-tests) for both recently collected and archived isolates. RESULTS: All feline E coli isolates and recently collected canine S intermedius isolates were susceptible to all fluoroquinolones. There was a statistically significant increase in the MIC range of ciprofloxacin and enrofloxacin for recently collected E coli, and in the MIC range of amoxycillin-clavulanate for recently collected S intermedius isolates compared to archived isolates. Twelve of 59 recently collected canine E coli isolates were resistant to both ciprofloxacin and enrofloxacin. Resistant canine E coli isolates were associated with complicating host or infection site factors. CONCLUSION: This is the first report comparing the MICs for all veterinary fluoroquinolones currently available in Australia for a representative sample of canine and feline E coli and canine S intermedius isolates. Importantly, this study identified 12 of 59 canine E coli isolates resistant to fluoroquinolones and identified the development of low level resistance in canine E coli to ciprofloxacin and enrofloxacin and canine S intermedius to amoxycillin-clavulanate.  相似文献   

Macrophage ribonucleoprotein: nature of the antigenic fragment   总被引：3，自引：0，他引：3  

A A Gottlieb 《Science (New York, N.Y.)》1969,165(893):592-594

The antigenic fragments of bacteriophage T2 recovered in RNA derived from macrophages infected with T2 bacteriophage retain their capacity to combine with specific neutralizing antibody to T2. The preservation of the complete native tertiary structure of tail fiber antigen of bacteriophage T2 is not requiired for immucnogenicity.  相似文献   

Scintigraphic Appearance of the Dorsal Cortex of the Third Metacarpus and Third Metatarsus in the Horse     

Sandra P. Schallberger  Dr. Med. Vet.    Marcus G. Doherr  Dr. Med. Vet.    Gottlieb Ueltschi  Prof. Dr. Med. Vet. 《Veterinary radiology & ultrasound》2004,45(4):352-356

The lack of "standard uptake pattern" to refer to when interpreting scintigraphic images poses a problem to anyone working with skeletal scintigraphy. An article written by Koblik et al. stated that in the normal scintigraphic image of older horses, the dorsal cortex of the metacarpus and metatarsus is not identifiable, whereas it can be identified in younger horses. In this retrospective study we evaluated the association between the age of a horse and visibility of the dorsal cortex of the metacarpus and metatarsus. We found that dorsal cortical uptake can be seen in the normal adult horse. The population in the study consisted of 139 horses scanned under general anesthesia in lateral recumbency. Scintigraphic images of 202 limbs were examined visually and by using a profile image tool. In almost all limbs the dorsal cortex was identifiable (82%); only 7% of the dorsal cortices were not identifiable; and 11% of the scintigraphic images were not interpretable.  相似文献   

Detection and Characterization of the Cumulene Carbenes H2C5 and H2C6     

MC McCarthy  MJ Travers  A Kovacs  W Chen  SE Novick  CA Gottlieb  P Thaddeus 《Science (New York, N.Y.)》1997,275(5299):518-520

Two cumulene carbenes, H2C5 and H2C6, were detected in a supersonic molecular beam by Fourier transform microwave spectroscopy. Their rotational and leading centrifugal distortion constants were determined with high accuracy, such that the entire radio spectrum can now be calculated. Like the known carbenes H2C3 and H2C4, both molecules have singlet electronic ground states and linear carbon-chain backbones. They can be produced in sufficiently high concentrations in the laboratory that their electronic spectra, expected to lie in the visible, should be readily detectable by laser spectroscopy. The microwave spectra of other, more exotic isomers may be detectable as well.  相似文献   

Effects of Draft Loaded Training on Circulatory and Blood Lactate Responses During Exercise in Horses     

Marianne Gottlieb  B. Essn-Gustavsson  S.G.B. Persson 《Journal of Equine Veterinary Science》1991,11(1)

Five Standardbred trotters were trained on a treadmill 3 times as week for 12 weeks by intervals of draft loaded exercise. The draft load was 34 kilopond and the velocity approximately 7 m/sec -1. Standardized exercise tests with sequentially increasing speed were performed before, and after 4, 8 and 11 weeks of training. No significant effects of training were seen on heart rate response to exercise or on total blood volume, red cell volume and plasma volume when related to bodyweight, whereas less blood lactate (p<0.05) was accumulated. Blood lactate response to exercise may therefore be valuable for monitoring metabolic adaptations to training by draft loaded exercise.  相似文献   

Degradation of the neolignan, burchellin in the hemolymph of the bloodsucking insect Rhodnius prolixus     

Cabral MM  Garcia ES  Gottlieb OR  Kelecom A 《Fitoterapia》2008,79(1):59-63

The neolignan, burchellin, a natural compound that reduces urine excretion in larvae of the bloodsucking bug, Rhodnius prolixus, a vector of Chagas' disease, is rapidly degraded in the hemolymph of the insect. The main product that accumulates in this tissue has been shown to be piperonyl alcohol. Other catabolites have been identified by GC-MS analysis.  相似文献   

Local retinal regions control local eye growth and myopia   总被引：25，自引：0，他引：25  

J Wallman  M D Gottlieb  V Rajaram  L A Fugate-Wentzek 《Science (New York, N.Y.)》1987,237(4810):73-77

In chicks, visual deprivation leads to myopia and enlargement of the vitreous chamber of the eye. When chicks were raised with white translucent occluders over their eyes so that either the nasal half, the temporal half, or all of the retina was visually deprived, the resulting myopia (median = -15 diopters) was limited to the deprived part of the retina, regardless of which half of the retina was visually deprived; the nondeprived part remained nearly emmetropic. Correspondingly, the vitreous chamber was elongated only in the region of the visual deprivation, resulting in eyes with different asymmetric shapes depending on which retinal region was deprived. These results argue for a local regulation of ocular growth that is dependent on vision and suggest a hypothesis to explain the epidemiological association of myopia in humans with large amounts of reading. Because most nonfoveal retinal neurons have large receptive fields, they cannot resolve the individual letters on the printed page; this may lead to their activity being less during reading than during most other forms of visual stimulation. Thus, the impoverished stimulus situation of reading may lead to myopia, as do other types of visual form deprivation.  相似文献   

Alabama and evolution     

Gottlieb SF  Fox S 《Science (New York, N.Y.)》1996,271(5247):275a

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Chromosome numbers     

Gottlieb LD 《Science (New York, N.Y.)》1980,209(4464):1507-1508

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Enzyme regulation in a trypanosomatid: effect of purine starvation on levels of 3'-nucleotidase activity   总被引：3，自引：0，他引：3  

M Gottlieb 《Science (New York, N.Y.)》1985,227(4682):72-74

Crithidia fasciculata, a nonpathogenic relative of the leishmanial and trypanosomal pathogens of humans and animals, showed a 3'-ribonucleotidase activity similar to that in Leishmania donovani. The level of 3'-nucleotidase activity in Crithidia was regulated by the availability of purines in the culture medium. Specifically, organisms obtained from culture medium depleted of purines contained elevated levels of enzyme activity compared to those grown in complete medium. The 3'-nucleotidase, located at the cell surface, may serve as a first step in purine salvage for these protozoa, which are unable to synthesize the purine ring de novo.  相似文献