Why scientists speak out     

Graham E 《Science (New York, N.Y.)》1966,152(3728):1458

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Standardized Pain Stimulation as Controlled Stress in Physiological Studies of Psychoneurosis     

Malmo RB  Shagass C  Davis JF  Cleghorn RA  Graham BF  Goodman AJ 《Science (New York, N.Y.)》1948,108(2810):509-511

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Biological weapons and international law     

Graham T 《Science (New York, N.Y.)》2002,295(5564):2325

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Evidence of estrogen receptors in normal human osteoblast-like cells   总被引：80，自引：0，他引：80  

E F Eriksen  D S Colvard  N J Berg  M L Graham  K G Mann  T C Spelsberg  B L Riggs 《Science (New York, N.Y.)》1988,241(4861):84-86

In seven strains of cultured normal human osteoblast-like cells, a mean of 1615 molecules of tritium-labeled 17 beta-estradiol per cell nucleus could be bound to specific nuclear sites. The nuclear binding of the labeled steroid was temperature-dependent, steroid-specific, saturable, and cell type-specific. These are characteristics of biologically active estrogen receptors. Pretreatment with 10 nanomolar estradiol in vitro increased the specific nuclear binding of progesterone in four of six cell strains, indicating an induction of functional progesterone receptors. RNA blot analysis demonstrated the presence of messenger RNA for the human estrogen receptor. The data suggest that estrogen acts directly on human bone cells through a classical estrogen receptor-mediated mechanism.  相似文献   

Sustainability. Anchovy fishery threat to Patagonian ecosystem     

Skewgar E  Boersma PD  Harris G  Caille G 《Science (New York, N.Y.)》2007,315(5808):45

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Integration between the epibranchial placodes and the hindbrain     

Begbie J  Graham A 《Science (New York, N.Y.)》2001,294(5542):595-598

Developmental integration results from coordination among components of different embryonic fields to realize the later anatomical and functional relationships. We demonstrate that in the chick head, integration between the epibranchial placodes and the hindbrain is achieved as the neuroglial hindbrain crest cells guide the epibranchial neuronal cells inward to establish their central connections. This work defines a role for the neuroglial hindbrain crest in organizing the afferent innervation of the hindbrain.  相似文献   

CO2 elicits long-term decline in nitrogen fixation     

Hungate BA  Stiling PD  Dijkstra P  Johnson DW  Ketterer ME  Hymus GJ  Hinkle CR  Drake BG 《Science (New York, N.Y.)》2004,304(5675):1291

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On the fringes of conquest: maya-spanish contact in colonial belize     

Graham E  Pendergast DM  Jones GD 《Science (New York, N.Y.)》1989,246(4935):1254-1259

The defeat of the Aztecs of Mexico by Hernán Cortés in 1521 was but the beginning of a long and torturous conquest of Central America that did not always result in the mastery of people and production for which the Spanish had hoped. The Maya of the resource-poor Yucatán peninsula were spared the heavy colonial hand that held fast to central Mexico and its riches. In addition, the dense forests of the peninsula served as a haven for refugees fleeing oppressive conditions in colonial towns. Despite the paucity of documentary information on Maya communities of the frontier, knowledge of Maya-Spanish relations in the 16th and 17th centuries has advanced in recent years through archeological and ethnohistorical research. Work in one region of the Maya lowlands has brought us closer to an understanding of the early interaction of the rulers and the ruled.  相似文献   

Crystal structure of the malaria vaccine candidate apical membrane antigen 1     

Pizarro JC  Vulliez-Le Normand B  Chesne-Seck ML  Collins CR  Withers-Martinez C  Hackett F  Blackman MJ  Faber BW  Remarque EJ  Kocken CH  Thomas AW  Bentley GA 《Science (New York, N.Y.)》2005,308(5720):408-411

Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design.  相似文献   

No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected     

Knox K  Carrigan D  Simmons G  Teque F  Zhou Y  Hackett J  Qiu X  Luk KC  Schochetman G  Knox A  Kogelnik AM  Levy JA 《Science (New York, N.Y.)》2011,333(6038):94-97

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