Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartzii in Macrophages via Blocking TLR/NF-Κb Signal Transduction     

Thilina U. Jayawardena  K. K. Asanka Sanjeewa  D. P. Nagahawatta  Hyo-Geun Lee  Yu-An Lu  A. P. J. P. Vaas  D. T. U. Abeytunga  C. M. Nanayakkara  Dae-Sung Lee  You-Jin Jeon 《Marine drugs》2020,18(12)

This study involves enzymatic extraction of fucoidan from Sargassum swartzii and further purification via ion-exchange chromatography. The chemical and molecular characteristics of isolated fucoidan is evaluated concerning its anti-inflammatory potential in RAW 264.7 macrophages under LPS induced conditions. Structural properties of fucoidan were assessed via FTIR and NMR spectroscopy. NO production stimulated by LPS was significantly declined by fucoidan. This was witnessed to be achieved via fucoidan acting on mediators such as iNOS and COX-2 including pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), with dose dependent down-regulation. Further, the effect is exhibited by the suppression of TLR mediated MyD88, IKK complex, ultimately hindering NF-κB and MAPK activation, proposing its therapeutic applications in inflammation related disorders. The research findings provide an insight in relation to the sustainable utilization of fucoidan from marine brown algae S. swartzii as a potent anti-inflammatory agent in the nutritional, pharmaceutical, and cosmeceutical sectors.  相似文献   

Methiozolin [5‐(2,6‐difluorobenzyl)oxymethyl‐5‐methyl‐3,3(3‐methylthiophen‐2‐yl)‐1,2‐isoxazoline], a new annual bluegrass (Poa annua L.) herbicide for turfgrasses     

Suk‐Jin Koo  Ki‐Hwan Hwang  Man‐Seok Jeon  Sung‐Hun Kim  Jongsoo Lim  Dong‐Guk Lee  Nam‐Gyu Cho 《Pest management science》2014,70(1):156-162

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Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review     

Kalu K. Asanka Sanjeewa  Kalahe H. I. N. M. Herath  Hye-Won Yang  Cheol Soo Choi  You-Jin Jeon 《Marine drugs》2021,19(12)

Fucoidans are sulfated heteropolysaccharides found in the cell walls of brown seaweeds (Phaeophyceae) and in some marine invertebrates. Generally, fucoidans are composed of significant amounts of L-fucose and sulfate groups, and lesser amounts of arabinose, galactose, glucose, glucuronic acid, mannose, rhamnose, and xylose. In recent years, fucoidans isolated from brown seaweeds have gained considerable attention owing to their promising bioactive properties such as antioxidant, immunomodulatory, anti-inflammatory, antiobesity, antidiabetic, and anticancer properties. Inflammation is a complex immune response that protects the organs from infection and tissue injury. While controlled inflammatory responses are beneficial to the host, leading to the removal of immunostimulants from the host tissues and restoration of structural and physiological functions in the host tissues, chronic inflammatory responses are often associated with the pathogenesis of tumor development, arthritis, cardiovascular diseases, diabetes, obesity, and neurodegenerative diseases. In this review, the authors mainly discuss the studies since 2016 that have reported anti-inflammatory properties of fucoidans isolated from various brown seaweeds, and their potential as a novel functional material for the treatment of inflammatory diseases.  相似文献   

The effect of size and quality of potato microtubers on quality of seed potatoes in the cultivar ‘Superior’     

Se Won Park  Jae Heung Jeon  Hyun Soon Kim  Se Jin Hong  C. Aswath  Hyouk Joung 《Scientia Horticulturae》2009

Potato microtubers produced in vitro of the cultivar ‘Superior’ were assessed to decide up to what size it can be used for the seed potato with respect to storability, dormancy period, and sprouting vigor. The larger microtubers lost moisture content more slowly and retained firmness longer when stored at 4 °C. In the sprouting test, the larger ones had less period of dormancy and showed more vigorous sprouting ability. The starch increased with increasing size of the microtuber and showed the distribution of about 70–80% of dry matter content. The amounts of sugars were positively co-related with the size of the potato. The internal factors such as dry matter and carbohydrate content reveal that potato microtuber follows the field-grown potatoes in all aspects. The results suggest that the size of microtubers can be used as an index for grading their quality as seed potatoes, and the size of the microtuber should be at least 0.5 g to be used as seed potato.  相似文献