Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs     

Bach JF  Rozanski EA  MacGregor J  Betkowski JM  Rush JE 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(5):1132-1135

Pulmonary arterial hypertension (PH) is a pathologic condition in dogs characterized by abnormally high pressures in the pulmonary circulation and has been associated with a poor outcome. Sildenafil is a type V phosphodiesterase inhibitor that produces nitric oxide mediated vasodilatation. Sildenafil treatment decreases pulmonary arterial pressure and pulmonary vascular resistance in people with PH. The purpose of this study was to describe the clinical characteristics and outcome of dogs with PH treated with sildenafil. The cardiology database was searched for dogs with PH treated with sildenafil. PH was defined as systolic pulmonary arterial pressure (PAPs) > or = 25 mmHg at rest. Medical records were reviewed for the following information: signalment, duration and type of clinical signs before treatment, underlying disease, estimated or measured PAPs, dosage and dosing interval of sildenafil, and the effect of treatment on clinical signs and pulmonary arterial pressure and survival time. Thirteen affected dogs were identified. Clinical signs included collapse, syncope, respiratory distress, and cough. Duration of clinical signs before presentation ranged from 3 days to 5 months. An underlying cause was identified in 8 dogs. The median sildenafil dosage was 1.9 mg/kg. Ten dogs received concurrent medications. Median PAPs was 90 mmHg; 8 dogs were reevaluated after therapy, and the median decrease in PAPs was 16.5 mmHg. The median survival time of all dogs was 91 days. Sildenafil appeared to be well tolerated in dogs with PH and was associated with decreased PAPs and amelioration of clinical signs in most. Sildenafil represents a reasonable treatment option for dogs with pulmonary hypertension.  相似文献   

Raccoonpox in a Canadian cat     

Yager JA  Hutchison L  Barrett JW 《Veterinary dermatology》2006,17(6):443-448

Poxvirus infections affecting the skin of cats are extremely rare in North America, in contrast to Europe where cowpox virus is well recognized as an accidental pathogen in cats that hunt small rodents. The virus or viruses responsible for the anecdotal cases in North America have never been characterized. This paper reports a case of raccoonpox infection in a Canadian cat. Biopsy of the initial ulcerative lesion on the forepaw revealed ballooning degeneration of surface and follicular keratinoctyes. Infected cells contained large eosinophilic type A inclusions. Electron microscopic examination revealed virions of an orthopoxvirus, subsequently identified as raccoonpox by polymerase chain reaction and gene sequencing. The cat made a full recovery.  相似文献   

A synthetic fraction of feline facial pheromones calms but does not reduce struggling in cats before venous catheterization     

Kronen PW  Ludders JW  Erb HN  Moon PF  Gleed RD  Koski S 《Veterinary anaesthesia and analgesia》2006,33(4):258-265

OBJECTIVE: To evaluate whether a synthetic analogue of feline facial pheromone (FFP) calms cats before, and reduces struggling during intravenous catheterization. DESIGN: Block-randomized, 'blinded' clinical trial. ANIMALS: Seventy-seven healthy cats presented for elective surgery. PROCEDURE: Cats given glycopyrrolate and oxymorphone were assigned to one of four treatments: acepromazine and exposure to FFP (aceFFP); acepromazine and exposure to a placebo (acePlac); exposure to FFP only (FFP) and exposure to placebo only (Plac). The behaviour of cats was recorded on videotape for evaluation by assessors unaware of treatment group. Cats' veins were then catheterized by veterinary students unaware of the study protocol. Based on each cat's response to catheterization, the student independently decided whether intramuscular ketamine was required. RESULTS: Cats in the aceFFP group appeared to be calmer than acePlac cats on the basis of head position and their location in the cage (suggesting benefit from FFP among cats receiving acepromazine) but appeared to be less sedated. Cats in the aceFFP group also appeared to be calmer than FFP cats on the basis of head position and location in the cage. Feline facial pheromone cats were also calmer than Plac cats when compared using body and leg position. Exposure to FFP did not significantly reduce struggling at catheterization, nevertheless, the students were able to catheterize the veins in all cats. CONCLUSION AND CLINICAL RELEVANCE: There were no detrimental behavioural effects associated with either FFP or acepromazine. The FFP had additional calming effects in cats given acepromazine and, to a lesser degree, helped to calm cats that were not given acepromazine. Feline facial pheromone helps to calm cats in unfamiliar surroundings.  相似文献   

Heterogeneous three-dimensional electronics by use of printed semiconductor nanomaterials     

Ahn JH  Kim HS  Lee KJ  Jeon S  Kang SJ  Sun Y  Nuzzo RG  Rogers JA 《Science (New York, N.Y.)》2006,314(5806):1754-1757

We developed a simple approach to combine broad classes of dissimilar materials into heterogeneously integrated electronic systems with two- or three-dimensional layouts. The process begins with the synthesis of different semiconductor nanomaterials, such as single-walled carbon nanotubes and single-crystal micro- and nanoscale wires and ribbons of gallium nitride, silicon, and gallium arsenide on separate substrates. Repeated application of an additive, transfer printing process that uses soft stamps with these substrates as donors, followed by device and interconnect formation, yields high-performance heterogeneously integrated electronics that incorporate any combination of semiconductor nanomaterials on rigid or flexible device substrates. This versatile methodology can produce a wide range of unusual electronic systems that would be impossible to achieve with other techniques.  相似文献   

Infrared spectroscopy of comet 81P/Wild 2 samples returned by Stardust     

Keller LP  Bajt S  Baratta GA  Borg J  Bradley JP  Brownlee DE  Busemann H  Brucato JR  Burchell M  Colangeli L  d'Hendecourt L  Djouadi Z  Ferrini G  Flynn G  Franchi IA  Fries M  Grady MM  Graham GA  Grossemy F  Kearsley A  Matrajt G  Nakamura-Messenger K  Mennella V  Nittler L  Palumbo ME  Stadermann FJ  Tsou P  Rotundi A  Sandford SA  Snead C  Steele A  Wooden D  Zolensky M 《Science (New York, N.Y.)》2006,314(5806):1728-1731

Infrared spectra of material captured from comet 81P/Wild 2 by the Stardust spacecraft reveal indigenous aliphatic hydrocarbons similar to those in interplanetary dust particles thought to be derived from comets, but with longer chain lengths than those observed in the diffuse interstellar medium. Similarly, the Stardust samples contain abundant amorphous silicates in addition to crystalline silicates such as olivine and pyroxene. The presence of crystalline silicates in Wild 2 is consistent with mixing of solar system and interstellar matter. No hydrous silicates or carbonate minerals were detected, which suggests a lack of aqueous processing of Wild 2 dust.  相似文献   

Organics captured from comet 81P/Wild 2 by the Stardust spacecraft     

Sandford SA  Aléon J  Alexander CM  Araki T  Bajt S  Baratta GA  Borg J  Bradley JP  Brownlee DE  Brucato JR  Burchell MJ  Busemann H  Butterworth A  Clemett SJ  Cody G  Colangeli L  Cooper G  D'Hendecourt L  Djouadi Z  Dworkin JP  Ferrini G  Fleckenstein H  Flynn GJ  Franchi IA  Fries M  Gilles MK  Glavin DP  Gounelle M  Grossemy F  Jacobsen C  Keller LP  Kilcoyne AL  Leitner J  Matrajt G  Meibom A  Mennella V  Mostefaoui S  Nittler LR  Palumbo ME  Papanastassiou DA  Robert F  Rotundi A  Snead CJ  Spencer MK  Stadermann FJ  Steele A 《Science (New York, N.Y.)》2006,314(5806):1720-1724

Organics found in comet 81P/Wild 2 samples show a heterogeneous and unequilibrated distribution in abundance and composition. Some organics are similar, but not identical, to those in interplanetary dust particles and carbonaceous meteorites. A class of aromatic-poor organic material is also present. The organics are rich in oxygen and nitrogen compared with meteoritic organics. Aromatic compounds are present, but the samples tend to be relatively poorer in aromatics than are meteorites and interplanetary dust particles. The presence of deuterium and nitrogen-15 excesses suggest that some organics have an interstellar/protostellar heritage. Although the variable extent of modification of these materials by impact capture is not yet fully constrained, a diverse suite of organic compounds is present and identifiable within the returned samples.  相似文献   

Impact features on Stardust: implications for comet 81P/Wild 2 dust     

Hörz F  Bastien R  Borg J  Bradley JP  Bridges JC  Brownlee DE  Burchell MJ  Chi M  Cintala MJ  Dai ZR  Djouadi Z  Dominguez G  Economou TE  Fairey SA  Floss C  Franchi IA  Graham GA  Green SF  Heck P  Hoppe P  Huth J  Ishii H  Kearsley AT  Kissel J  Leitner J  Leroux H  Marhas K  Messenger K  Schwandt CS  See TH  Snead C  Stadermann FJ  Stephan T  Stroud R  Teslich N  Trigo-Rodríguez JM  Tuzzolino AJ  Troadec D  Tsou P  Warren J  Westphal A  Wozniakiewicz P  Wright I  Zinner E 《Science (New York, N.Y.)》2006,314(5806):1716-1719

Particles emanating from comet 81P/Wild 2 collided with the Stardust spacecraft at 6.1 kilometers per second, producing hypervelocity impact features on the collector surfaces that were returned to Earth. The morphologies of these surprisingly diverse features were created by particles varying from dense mineral grains to loosely bound, polymineralic aggregates ranging from tens of nanometers to hundreds of micrometers in size. The cumulative size distribution of Wild 2 dust is shallower than that of comet Halley, yet steeper than that of comet Grigg-Skjellerup.  相似文献   

Solid-state qubits with current-controlled coupling     

Hime T  Reichardt PA  Plourde BL  Robertson TL  Wu CE  Ustinov AV  Clarke J 《Science (New York, N.Y.)》2006,314(5804):1427-1429

The ability to switch the coupling between quantum bits (qubits) on and off is essential for implementing many quantum-computing algorithms. We demonstrated such control with two flux qubits coupled together through their mutual inductances and through the dc superconducting quantum interference device (SQUID) that reads out their magnetic flux states. A bias current applied to the SQUID in the zero-voltage state induced a change in the dynamic inductance, reducing the coupling energy controllably to zero and reversing its sign.  相似文献   

Retrospective: Edward I. Stiefel (1942-2006)     

Morel FM  Groves JT 《Science (New York, N.Y.)》2006,314(5804):1406

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Impacts of biodiversity loss on ocean ecosystem services   总被引：1，自引：0，他引：1  

Worm B  Barbier EB  Beaumont N  Duffy JE  Folke C  Halpern BS  Jackson JB  Lotze HK  Micheli F  Palumbi SR  Sala E  Selkoe KA  Stachowicz JJ  Watson R 《Science (New York, N.Y.)》2006,314(5800):787-790

Human-dominated marine ecosystems are experiencing accelerating loss of populations and species, with largely unknown consequences. We analyzed local experiments, long-term regional time series, and global fisheries data to test how biodiversity loss affects marine ecosystem services across temporal and spatial scales. Overall, rates of resource collapse increased and recovery potential, stability, and water quality decreased exponentially with declining diversity. Restoration of biodiversity, in contrast, increased productivity fourfold and decreased variability by 21%, on average. We conclude that marine biodiversity loss is increasingly impairing the ocean's capacity to provide food, maintain water quality, and recover from perturbations. Yet available data suggest that at this point, these trends are still reversible.  相似文献