Use of Oncept melanoma vaccine in 69 canine oral malignant melanomas in the UK          下载免费PDF全文

S. Verganti  D. Berlato  L. Blackwood  I. Amores‐Fuster  G. A. Polton  R. Elders  R. Doyle  A. Taylor  S. Murphy 《The Journal of small animal practice》2017,58(1):10-16

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Uveodermatologic syndrome in a rat terrier     

Blackwood SE  Barrie KP  Plummer CE  Taylor D  Nunnery CM  Seltzer JD  Ben-Shlomo G  Brooks DE 《Journal of the American Animal Hospital Association》2011,47(4):e56-e63

A 4 yr old intact male rat terrier presented with severe bilateral nonresponsive panuveitis. Bilateral uveitis, blepharospasm, conjunctival hyperemia, diffuse corneal edema, peripheral bullous retinal detachment, and secondary ocular hypertension were noted. Ocular lesions progressed despite aggressive medical treatment and were followed by cutaneous depigmentation and crusting along the nasal planum. Intensive oral and topical anti-inflammatory and topical antiglaucoma medications were administered, but the ocular disease progressed. A bilateral enucleation was performed. Uveodermatologic syndrome was diagnosed from histopathologic examination of a skin biopsy as well as histopathology of both globes after bilateral enucleation. To maintain control of the dermatologic lesions, oral azathioprine was initiated, but it was not well tolerated by this patient. Immunosuppressive doses of oral cyclosporine and anti-inflammatory doses of oral prednisone were used to control the depigmentation and crusting skin lesions.  相似文献   

The effect of boric acid on bacterial culture of canine and feline urine     

Rowlands M  Blackwood L  Mas A  Cripps P  Crompton C  Burrow R 《The Journal of small animal practice》2011,52(10):510-514

Objective : To identify the optimal method of submission of canine and feline urine for bacterial culture. Methods : Cystocentesis samples from 250 animals (200 dogs, 50 cats) suspected of having urinary tract infections were collected. The reference aliquot, without preservative, was processed on site within 2 hours. Two further aliquots (one without preservative, one with boric acid) were stored at room temperature for up to 7 hours and then posted by guaranteed next day delivery to a commercial laboratory for analysis. Results : Forty‐seven of the samples were positive on culture in the reference test. There was no significant difference between reference test results and those of samples posted without preservative (P=0·39), but samples posted in boric acid were significantly less likely to give a positive result (P=0·01). Samples posted without preservative had a sensitivity of 82% and a specificity of 98%; for boric acid, sensitivity was 73% and specificity 99%. Clinical Significance : Postal urine samples should be submitted to the laboratory in a plain sterile tube.  相似文献   

Classical swine fever in Victorian domestic pigs: evidence of disease freedom     

JC Hunnam  KM Moore  P Daniel  MA Stevenson  SE Salmon 《Australian veterinary journal》2019,97(11):447-451

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Haematologic toxicity in dogs with mast cell tumours treated with vinblastine/prednisolone chemotherapy with/without radiotherapy     

K. Stiborova  E. Treggiari  I. Amores‐Fuster  I. del Busto  D. Killick  T. Maddox  M. Marrington  S. L. Mason  L. Blackwood 《The Journal of small animal practice》2019,60(9):534-542

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Dachshund bitch with severe uterine adhesions and intramural uterine foreign material as an incidental ovariohysterectomy finding          下载免费PDF全文

KM Watson  NU Horadagoda  SA Piripi 《Australian veterinary journal》2016,94(1-2):24-26

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Sequence diversity of the immunogenic outer membrane lipoprotein PlpE from Mannheimia haemolytica serotypes 1, 2, and 6     

Ayalew S  Blackwood ER  Confer AW 《Veterinary microbiology》2006,114(3-4):260-268

Mannheimia haemolytica serotype 1 (S1), S6 and S2 are the most common bacterial isolates found in shipping fever pneumonia in beef cattle. Currently used vaccines against M. haemolytica do not provide complete protection against the disease. Research with M. haemolytica outer membrane proteins (OMPs) has shown that antibodies to one particular OMP from S1, PlpE, may be important in immunity. Recombinant PlpE (rPlpE) is highly immunogenic in cattle, and the acquired immunity markedly enhanced resistance to experimental challenge. We previously demonstrated that the immunodominant epitope (R2) is located between residues 26 and 76 on the N-terminus of PlpE from a reference S1 strain (). This region consists of eight hexapeptide repeats. The potential of this epitope as a vaccine or supplement to commercial vaccines is dependant on its state of conservation amongst isolates of the three serotypes. To determine this, we sequenced plpE genes from 32 isolates. The sequences from S1 and S6 were identical with one exception. Substantial variation was observed among sequences from S2 strains, particularly in the R2 region of the protein. These variations in S2 isolates range from 3 to 28 hexapeptide repeats. Calculated molecular weight of PlpE from S1 and S6 isolates was 37 kDa, where as PlpE from S2 strains ranged from 30 to 50 kDa. These similarities and differences were demonstrated by western blot. Competitive binding assay was used to determine that antibody against rPlpE from S1 binds native PlpE on surfaces of both S1 and S2 cells.  相似文献   

Chronic Murine Pneumonia: A Review          下载免费PDF全文

N. N. Joshi  A. C. Blackwood    D. G. Dale 《Canadian journal of veterinary research》1961,25(11):267-273

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Hypocobalaminaemia is uncommon in cats in the United Kingdom     

Ibarrola P  Blackwood L  Graham PA  Evans H  German AJ 《Journal of Feline Medicine and Surgery》2005,7(6):341-348

Recent work has highlighted the importance of cobalamin deficiency in cats with a range of alimentary tract diseases. The primary aim of our study was to determine the incidence of subnormal cobalamin concentrations in sick cats with and without alimentary system disorders. Firstly, serum cobalamin concentrations were measured in a population of cats, with and without gastrointestinal (GI) disease, evaluated at a referral hospital. In the second part of the study, the incidence of cobalamin deficiency was assessed in samples submitted to a commercial laboratory specifically for cobalamin measurement. For both studies, a validated radioimmunoassay was used to measure serum cobalamin concentrations (reference range: > 150 pg/ml). In the first part of the study, 132 cats were included and none of these cats had subnormal cobalamin concentrations (median=1,172; range: 278 to >2,000). There were no differences in cobalamin concentrations between cats with alimentary system disorders, and those with diseases of other organs. In the second part, 682 samples were submitted for cobalamin assay over a period of 3 years, and only one cat had a result below the reference range (median=794; range: 147 to >2,000). Cobalamin deficiency was rare in the population tested and this may suggest that the incidence of this biochemical abnormality is less common than reported in the USA.  相似文献   

Is schizophrenia linked to chromosome 1q?     

Macgregor S  Visscher PM  Knott S  Porteous D  Muir W  Millar K  Blackwood D 《Science (New York, N.Y.)》2002,298(5602):2277; author reply 2277

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