A tool set to allow rapid screening of dog families with PRA for association with candidate genes          下载免费PDF全文

Paige A. Winkler  Jennifer A. Davis  Simon M. Petersen‐Jones  Patrick J. Venta  Joshua T. Bartoe 《Veterinary ophthalmology》2017,20(4):372-376

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Rainfall,evapotranspiration, and soil moisture as herbage production predictors for Wyoming rangelands     

Tegenu A. Engda  Ginger B. Paige  Ann L. Hild 《Arid Land Research and Management》2016,30(4):445-459

Rangelands are an important ecosystem in the western US, and herbage and livestock production are important issues throughout the western states. Making stocking rate decisions early in the growing season is difficult because of high variation in annual herbage production. In this study, regression analysis was used to relate herbage biomass to monthly and growing season predicator variables (rainfall, actual evapotranspiration, and soil moisture) using data collected from fifteen Wyoming rangeland sites. Both predictor and response variables were scaled before regression to correct for different physical and environmental conditions between sites. Growing season precipitation was the strongest predictor of herbage biomass production (r² = 0.79), followed by growing season actual evapotranspiration (r² = 0.69), and growing season profile-average soil water content (r² = 0.59). April profile-average (0–90 cm) and April surface (0–30 cm) soil moisture also predicted herbage biomass (r² = 0.53–0.54), indicating that early growing season soil moisture can be used to inform stocking rate and grazing management decisions as it provides information at the onset of the growing season.  相似文献   

Chemical characterization of dissolvable tobacco products promoted to reduce harm     

Rainey CL  Conder PA  Goodpaster JV 《Journal of agricultural and food chemistry》2011,59(6):2745-2751

In 2009, the R. J. Reynolds Tobacco Co. released a line of dissolvable tobacco products that are marketed as an alternative to smoking in places where smoking is prohibited. These products are currently available in Indianapolis, IN, Columbus, OH, and Portland, OR. This paper describes the chemical characterization of four such products by gas chromatography-mass spectrometry (GC-MS). The dissolvable tobacco products were extracted and prepared by ultrasonic extraction using acetone, trimethylsilyl derivatization, and headspace solid phase microextraction (SPME). The following compounds were identified in the dissolvables using either ultrasonic extractions or trimethylsilyl derivatization: nicotine, ethyl citrate, palmitic acid, stearic acid, sorbitol, glycerol, and xylitol. The following compounds were identified in the dissolvables using headspace SPME: nicotine, ethyl citrate, cinnamaldehyde, coumarin, vanillin, and carvone. With the exception of nicotine, the compounds identified thus far in the dissolvables are either flavoring compounds or binders. The concentration of free nicotine in the dissolvables was determined from the Henderson-Hasselbalch equation and by measuring the pH and nicotine concentration by GC-MS. The results presented here are the first to reveal the complexity of dissolvable tobacco products and may be used to assess potential oral health effects.  相似文献   

Plants of a feather: Spatial autocorrelation of gardening practices in suburban neighborhoods     

Paige S. Warren 《Biological conservation》2008,141(1):3-4

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Arthroscopic approach to the subextensorius recess of the lateral femorotibial joint of the foal     

Hennessy SE  Cudmore L  Jackson LP  Vasey JR  Russell T 《Veterinary surgery : VS》2012,41(4):529-535

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Kiricephalus coarctatus in an Eastern Indigo Snake (Drymarchon couperi); endoscopic removal, identification, and phylogeny     

AP Brock  AE Gallagher  HD Walden  JL Owen  MD Dunbar  HL Wamsley  AB Schoeller  AL Childress  JF Wellehan 《The Veterinary quarterly》2012,32(2):107-112

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What Is Your Diagnosis?     

Andreasen CB  Carmichael P 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1992,21(3):77-78

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Hypertrichosis in a horse with alimentary T-cell lymphoma and pituitary involvement.     

Ikki Mitsui  L Paige Jackson  Laurent L Cou?til  Tsang L Lin  José A Ramos-Vara 《Journal of veterinary diagnostic investigation》2007,19(1):128-132

A 13-year-old Quarterhorse mare had a 6-month history of diarrhea, progressive weight loss, and lethargy. At presentation the mare was hirsute, had hyperhidrosis, and abnormal fat distribution in addition to severe diarrhea. A presumptive clinical diagnosis of protein-losing enteropathy and pituitary pars intermedia dysfunction was made. T-cell lymphoma was diagnosed in a rectal biopsy specimen. The owner elected to euthanize the mare because of poor prognosis and the severity of the disease. At necropsy, the mare had hypertrichosis and the pituitary gland was diffusely enlarged. Histologically, neoplastic lymphocytes infiltrated the gastrointestinal mucosa, mesenteric lymph nodes, and the pituitary gland. In addition, there was hyperplasia of the pituitary gland pars intermedia. Pituitary adenoma was not present. Hypertrichosis in this case could have been triggered by a combination of adenomatous hyperplasia of pars intermedia and lymphoma resulting in disruption of the hypothalamic dopaminergic tone or disruption of the hypothalamic thermoregulatory center.  相似文献   

Evaluation of hematological, chemistry and blood gas values in dogs receiving hemoglobin glutamer-200     

Marie E. Kerl  DVM  DACVIM  DACVECC    Paige F. Langdon  DVM  DACVIM    Charles E. Wiedmeyer  DVM  PhD  DACVP    Keith R. Branson  DVM  DACVA 《Journal of Veterinary Emergency and Critical Care》2007,17(1):37-44

Objective: To evaluate the degree of interference that administration of hemoglobin glutamer‐200 (Hb‐200) caused for complete blood counts (CBC), biochemical profiles, cooximetry, and point of care (POC) testing in healthy dogs. Design: Prospective, longitudinal experimental study. Setting: Veterinary medical teaching hospital. Animals: Six purpose‐bred research hounds. Interventions: Dogs were administered FDA‐approved hemoglobin‐based oxygen carrier (Hb‐200) intravenously at 7.5 mL/kg over 2 hours. Arterial and venous blood samples were obtained before administration (Time 0) and at 3, 8, 14, 26, 50, 74, 98, 122, and 146 hours following administration. Measurements and main results: No adverse health effects were observed in any of the dogs. Characteristic mucous membrane, serum, and plasma color changes occurred following administration of Hb‐200. Laboratory values that were significantly lower than baseline included packed cell volume, red blood cell count, hemoglobin, hematocrit, creatinine, cholesterol, alanine aminotransferase, and alkaline phosphatase. Laboratory values that were significantly greater than baseline included mean corpuscular hemoglobin concentration, arterial pH, arterial total carbon dioxide, arterial bicarbonate, amylase, albumin, total protein, globulin, calcium, phosphorous, total bilirubin, carboxyhemoglobin, and methemoglobin. All values returned to baseline by the completion of the 146‐hour monitoring period. Conclusions: In normal dogs, administration of Hb‐200 resulted in statistically significant changes in multiple laboratory parameters; however, these changes are not likely to be clinically significant in the care of critically ill dogs.  相似文献   

Allosteric activators of glucokinase: potential role in diabetes therapy     

Grimsby J  Sarabu R  Corbett WL  Haynes NE  Bizzarro FT  Coffey JW  Guertin KR  Hilliard DW  Kester RF  Mahaney PE  Marcus L  Qi L  Spence CL  Tengi J  Magnuson MA  Chu CA  Dvorozniak MT  Matschinsky FM  Grippo JF 《Science (New York, N.Y.)》2003,301(5631):370-373

Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as pancreatic beta cells and hepatocytes. We describe a class of antidiabetic agents that act as nonessential, mixed-type GK activators (GKAs) that increase the glucose affinity and maximum velocity (Vmax) of GK. GKAs augment both hepatic glucose metabolism and glucose-induced insulin secretion from isolated rodent pancreatic islets, consistent with the expression and function of GK in both cell types. In several rodent models of type 2 diabetes mellitus, GKAs lowered blood glucose levels, improved the results of glucose tolerance tests, and increased hepatic glucose uptake. These findings may lead to the development of new drug therapies for diabetes.  相似文献