Amoxycillin: distribution and clinical efficacy in calves.     

G H Palmer  R J Bywater  M E Francis 《The Veterinary record》1977,100(23):487-491

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Clinical and hematologic variables in ponies with experimentally induced equine ehrlichial colitis (Potomac horse fever)   总被引：2，自引：0，他引：2  

E L Ziemer  R H Whitlock  J E Palmer  P A Spencer 《American journal of veterinary research》1987,48(1):63-67

The clinical and hematologic variables of 10 ponies with experimentally induced equine ehrlichial colitis (EEC; syn: Potomac horse fever) were studied for a 30-day period (6 ponies) or until death (4 ponies). The earliest clinical sign indicative of EEC was fever (rectal temperature exceeding 39 C). All ponies became depressed (CNS) at various times during the disease, and 90% of the ponies developed diarrhea between 9 and 15 days after infection was induced. The most significant hematologic change was an increase in plasma protein concentration after the onset of fever (P less than 0.05). The PCV in all ponies became increased above base line during the diarrheic phase of EEC. Forty percent of the ponies developed anemia (PCV less than or equal to 23%) during the study. White blood cell counts were highly variable, with 80% of the ponies developing leukopenia (WBC less than 5,000/microliters) during the illness and 60% of the ponies developing leukocytosis (WBC greater than 14,000/microliters) after leukopenia was observed. Differential WBC changes varied widely and included neutropenia with a left shift, lymphopenia, and eosinopenia. Serial thrombocyte counts, which were done for only 1 pony, identified the development of marked thrombocytopenia. Some hematologic changes in ponies with EEC were similar to those reported in canine monocytic and equine granulocytic ehrlichioses. These data are discussed in the context of the pathogenesis and differential diagnosis of EEC.  相似文献   

Enzootic septicemic listeriosis in a migrating flock of sheep     

D G Palmer 《Schweizer Archiv für Tierheilkunde》1984,126(10):539-543

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Congenital cutaneous, oral, and periarticular hemangiosarcoma in a 9-day-old Rocky Mountain horse     

Dunkel BM  Del Piero E  Kraus BM  Palmer JE  Lin P  Wilkins PA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(2):252-255

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Canine parvovirus outbreaks     

Palmer J  Thornley M 《Australian veterinary journal》2004,82(12):720-720

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D-lactate production and excretion in diarrheic calves     

Ewaschuk JB  Naylor JM  Palmer R  Whiting SJ  Zello GA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(5):744-747

The origin of D-lactate, the most important acid contributing to metabolic acidosis in the diarrheic calf, is unknown. We hypothesized that because D-lactate is produced only by microbes, gastrointestinal fermentation is the source. The objective of this study was to determine whether D-lactate production occurs in the rumen, colon, or both, and to measure D- and L-lactate concentrations in urine. Fecal, rumen, blood, and urine samples were obtained from 16 diarrheic and 11 healthy calves. Serum electrolyte concentrations were measured in both groups, and blood gas analyses were performed for diarrheic calves. All samples were analyzed for D- and L-lactate by high performance liquid chromatography (HPLC). Diarrheic calves were generally hyperkalemic with high serum anion gap, depressed serum bicarbonate, and low blood pH. L-lactate was markedly higher in rumen contents (22.7 mmol/ L [median]) and feces (8.6 mmol/L) of diarrheic calves than healthy calves (0.5 mmol/L and 5.1 mmol/L, respectively), but not different in serum or urine. Rumen, fecal, serum, and urine D-lactate concentrations were all significantly higher (P < .05) in diarrheic calves (17.0, 25.4, 13.9, and 19.2 mmol/L, respectively) than in healthy calves (0.5, 9.1, 1.4, and 0.5 mmol/L, respectively). Higher D-lactate concentrations in the rumen and feces of diarrheic calves suggests these sites as the source of D-lactate in blood and urine.  相似文献   

Antigen-specific proliferation and activation of peripheral blood mononuclear cells from Mycobacterium bovis-infected reindeer     

Waters WR  Palmer MV  Thacker TC  Minion FC  Davis WC 《Veterinary immunology and immunopathology》2006,111(3-4):263-277

To evaluate antigen-specific proliferative and activation-associated responses from Mycobacterium bovis-infected reindeer, blood mononuclear cells from M. bovis- (n = 10) and non-infected reindeer (n = 4) were stimulated with a recombinant early secretory antigenic target-6 and culture filtrate protein-10 fusion protein (rESAT6:CFP10), M. bovis purified protein derivative, pokeweed mitogen, or medium alone and evaluated by flow cytometry using dye tracker analysis and cell surface marker staining. gammadelta TCR+ and CD8+ cells, but not CD4+ cells, from M. bovis-infected reindeer proliferated in response to specific antigen stimulation. Expression (i.e., mean fluorescence intensity) of CD44 was increased and CD62L decreased on proliferative as compared to non-proliferative fractions in antigen- and mitogen-stimulated cultures. In response rESAT6:CFP10 stimulation, MHC II fluorescence intensity was increased on CD4+, gammadelta TCR+, CD172a+, and IgM+ cells from infected reindeer as compared to that of non-stimulated cells from the same reindeer. Recombinant ESAT6:CFP10 stimulation also induced expansion of a CD172a+, MHC II+ population within mononuclear cell cultures from M. bovis-infected reindeer. Despite a moderate challenge dose and extended duration of incubation, experimental infection of reindeer was generally limited to lymph nodes draining the inoculation site, suggestive of host resistance to progressive disease. Present in vitro findings, therefore, may be predictive of host responses by reindeer that limit progression to disseminated disease.  相似文献   

Effect of day and night temperature on the expression of male sterility of nuclear male-sterile (ms8ms8) soybean     

P. T. Perez-Sackett  R. G. Palmer 《Euphytica》2012,186(3):847-853

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Ecology. The heartbeat of ecosystems     

Palmer MA  Febria CM 《Science (New York, N.Y.)》2012,336(6087):1393-1394

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Immunoperoxidase study of adenovirus pneumonia in dogs     

R. Ducatellet  D. Palmer  P. Ossene  J. Hoorens 《The Veterinary quarterly》2013,33(4):290-296

Summary

The pathology of adenovirus pneumonia in 16 dogs is described. Clinically, these dogs had been severely ill, with severe dyspnoea and listlessness, but only faint coughing.

Histopathological lesions could be associated directly with the presence of adenovirus antigens in the lungs of these dogs by using an unlabelled immunoperoxidase technique on paraffin tissue sections. The lesions were focal and located in alveoli and bronchioles. Infected cells were mostly alveolar macrophages and less frequently type I and 2 pneumocytes and bronchiolar epithelial cells. Infiltrating neutrophils and lymphocytes were not observed to be infected.

This type of pneumonia appears to be a fairly well defined clinical and pathological entity in kennel dogs.  相似文献