U.S., Europe, Japan look to speed up drug reviews     

Normile D  Marshall E 《Science (New York, N.Y.)》2000,287(5460):1958-1959

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Biotechnology. Disease group invests in do-it-yourself drugs     

Marshall E 《Science (New York, N.Y.)》2000,288(5472):1715b-1717b

On 31 May, the Cystic Fibrosis (CF) Foundation of Bethesda, Maryland, announced that it will invest at least $30 million in a small biotech firm, Aurora Biosciences of San Diego, to identify compounds that might prove useful in treating CF. This project, fueled initially by a donation of $20 million from the Bill and Melinda Gates Foundation, marks a new departure in the growing trend of patient groups taking charge of biomedical research.  相似文献   

Ethics. Epidemiologists wary of opening up their data     

Marshall E 《Science (New York, N.Y.)》2000,290(5489):28-29

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应用轻型飞机防治马尾松毛虫的试验Ⅰ．喷施四种药剂防治的效果     

朱少木洪宜聪  张华庭乐兴钊 刘金亮 《昆虫天敌》2007,29(1):21-25

马尾松毛虫Dendrolimus punctatus Walker是马尾松林重要害虫。林间应用超轻型飞机大面积喷洒溴氰菊酯超低容量喷雾、白僵菌纯孢子油剂、菌药混合液超低容量喷雾以及喷洒白僵菌菌粉,其防治效果分别为96．5%、85．7%、95．6%、86．5%。上述的防治措施可作为单独的措施或综合防控中的配套措施使用,同时应用飞机防治解决了树高、林密、水源缺乏、劳力工资昂贵等条件给防治工作带来的困难,是一种适应林区林业生产整体水平而又快速、高效、经济的防治手段。  相似文献   

使用Cytoscape对生物网络数据的建模和分析     

江珊  蒋勃  徐桂珍  李继红  乐毅 《农业网络信息》2017,(6)

生物网络是系统生物学研究的重要内容。本文介绍了多种常用复杂生物网络可视化系统,针对Cytoscape系统在可视化的建模过程以及在建模过程中使用到的布局算法进行对比研究,并利用Cytoscape系统中丰富的插件对复杂网络数据进行分析,包括对数据进行网络分析和更改、使用BINGO插件进行基因注释、使用AGILENT LITERATURE SEARCH(ALS)插件搜索基因相互作用文献等。  相似文献   

DEBLOOMING MINERAL OILS     

Marshall DT 《Science (New York, N.Y.)》1892,19(482):245-246

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Relative calving date of first-calf heifers as related to production efficiency and subsequent reproductive performance     

D M Marshall  W Minqiang  B A Freking 《Journal of animal science》1990,68(7):1812-1817

Relative date of first calving of beef heifers was studied in relation to production efficiency and subsequent reproductive performance. Crossbred heifers were managed in a drylot environment for 1 yr with feed intake measured through weaning of the first calf. Mean heifer age at entry into drylot was 572 d. Production traits were evaluated by calving group (CG), where CG1 included records of heifers calving (and calves born) in the first 21 d of the calving season for a particular year, CG2 included those calving from 22 through 42 d and CG3 included those calving after 42 d. Calving groups did not differ significantly for preweaning calf ADG, but weaning age differences resulted in heavier weaning weights for CG1 compared with CG2 and CG3. An earlier relative calving date was associated with increased cumulative feed energy intake of heifers and their calves during the 1-yr test period. In terms of production efficiency, the weaning weight advantage of earlier calving was offset only partly by the increased feed energy intake of the dam-calf unit, resulting in 6.3 Mcal (12.4%) less ME per kg calf weaning weight for CG1 vs CG3 for the 1-yr period. Within a limited calving season, earlier calving dams tended to be biologically and economically more efficient because a greater proportion of their annual production cycle was in a productive (lactating) mode, diluting maintenance costs as a fraction of all costs. Heifers in CG1 also tended to calve earlier than CG3 heifers for the second calf. Calving interval was a biased measure under the management conditions of a limited breeding season and culling of open cows.  相似文献   

Immune system theories on trial     

E Marshall 《Science (New York, N.Y.)》1986,234(4783):1490-1492

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The lessons of Chernobyl     

E Marshall 《Science (New York, N.Y.)》1986,233(4771):1375-1376

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Effect of lipoic acid on redox regulation,digestive and absorptive function in intestine of mice fed high fat diet     

LI Wu  SHI Yong-hui  YANG Rui-li  YUE Peng  LE Guo-wei 《园艺学报》2009,25(3):577-580

AIM:To elucidate the molecular mechanisms of lipoic acid (LA) on redox regulation and digestive function in intestine of C57BL/6 mice fed high fat diet (HFD).METHODS:C57BL/6 mice were randomly assigned to one of three groups (n=8).The control group consumed an ordinary diet.The other two experimental groups were fed with a high fat diet, high fat plus 0.1% LA.After 6 weeks, the activities of digestive enzymes were examined.In order to evaluate the antioxidant status of the mice, superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC) and reactive oxygen species (ROS) in intestinal homogenate were measured.To investigate the molecular mechanisms underlying the effects of LA, the gene expression profiles in intestine were examined using the GeneChip microarray system.RESULTS:A depressed antioxidant defense system, accompanied by digestive and absorptive function impairment, was observed in HFD-fed mice.These changes were partially restored in the LA-treated group.DNA microarray analysis of intestine showed that LA ingestion up-regulated the expression of genes related to free-radical scavenger enzymes, digestive enzymes and transporters.CONCLUSION:Treatment with LA improves redox homeostasis and the function of intestine in mice fed HFD.The mechanism may involve preventing oxidative stress by scavenging ROS directly and increasing those of free-radical scavenger enzymes gene expression indirectly.  相似文献