Survey of the therapeutic approach and efficacy of pentosan polysulfate for the prevention and treatment of equine osteoarthritis in veterinary practice in Australia     

CM Kramer  AS Tsang  T Koenig  LB Jeffcott  CM Dart  AJ Dart 《Australian veterinary journal》2014,92(12):482-487

  相似文献   

Effective control of a suspected cyromazine‐resistant strain of Lucilia cuprina using commercial spray‐on formulations of cyromazine or dicyclanil     

KE Baker  PF Rolfe  AJ George  KJ Vanhoff  PF Kluver  JN Bailey 《Australian veterinary journal》2014,92(10):376-380

  相似文献   

Evaluation of Cheetah and Leopard Spermatozoa Developmental Capability after Interspecific ICSI with Domestic Cat Oocytes     

LN Moro  AJ Sestelo  DF Salamone 《Reproduction in domestic animals》2014,49(4):693-700

The ICSI procedure is potentially of great value for felids, and it has not been extensively studied in these species. The objectives of this work were to determine the best conditions for ICSI in the domestic cat (DC) to generate interspecific embryos by injecting cheetah (Ch) and leopard (Leo) spermatozoa. Firstly, DC oocytes were matured with insulin–transferrin–selenium (ITS) or without it (MM) and cultured using atmospheric (21%) or low (5%) oxygen tension after ICSI. The group ITS‐5%O₂ showed the highest blastocyst rate (p < 0.05), 20.9% vs 8.7%, 7% and 6.5%, for MM‐21%O₂, MM‐5%O₂ and ITS‐21%O₂, respectively. The best conditions were used to generate the interspecific embryos, together with ionomycin activation (Io) after ICSI. Interspecific embryos resulted in high rates of blastocysts that were not positively affected by Io activation: 32.6% vs 21% for Ch and Ch‐Io, 9.8% vs 21% for Leo and Leo‐Io, and 20% vs 17.4% for DC and DC‐Io. We also evaluated DNA‐fragmented nuclei of experiment 1 and 2 blastocysts, using TUNEL assay. The fragmented nucleus proportion was higher in the ITS‐5%O₂ group, 67.6%. Surprisingly, interspecific blastocysts showed the lowest fragmented nucleus proportion: 27% and 29.9% for Ch and Leo, respectively. We concluded that ITS and 5%O₂ improve blastocyst formation in DC, although with a concomitant increase in DNA fragmentation. Most importantly, cheetah and leopard spermatozoa were able to generate blastocysts without artificial activation, which suggests that developmental capacity of wild felid spermatozoa can be evaluated by interspecific ICSI. This technique should be used to assist wild felid reproduction.  相似文献   

Concentrations of 15F2t isoprostane in urine of dogs with intervertebral disk disease     

McMichael MA  Ruaux CG  Baltzer WI  Kerwin SC  Hosgood GL  Steiner JM  Williams DA 《American journal of veterinary research》2006,67(7):1226-1231

OBJECTIVE: To measure 15F(2t) isoprostane concentrations in the urine of dogs undergoing ovariohysterectomy (OHE) and dogs undergoing surgery because of intervertebral disk disease (IVDD) and to assess relationships between urinary concentrations of 15F(2t) isoprostanes and neurologic score in dogs with IVDD. ANIMALS: 11 dogs undergoing OHE and 32 dogs with IVDD undergoing hemilaminectomy. PROCEDURES: Paired urine samples were obtained at induction of anesthesia and approximately 1 hour after OHE (controls) and were collected from dogs with IVDD at induction of anesthesia (28 samples) and approximately 1 hour after hemilaminectomy (31 samples); 26 paired urine samples were obtained from dogs with IVDD. Urinary isoprostane concentrations were measured by use of a commercial ELISA, and results were adjusted on the basis of urinary creatinine concentrations. Differences in the mean isoprostane-to-creatinine ratio were analyzed. Neurologic score was determined in dogs with IVDD by use of the modified Frankel scoring system. RESULTS: Urinary isoprostane-to-creatinine ratios were significantly higher in dogs with IVDD than in control dogs before and after surgery. There was no significant difference between values before and after surgery for either group. There was a significant correlation of neurologic score and urinary isoprostane-to-creatinine ratio because dogs that had higher neurologic scores (ie, less severely affected) generally had higher isoprostane-to-creatinine ratios. CONCLUSIONS AND CLINICAL RELEVANCE: Urinary isoprostane-to-creatinine ratios were higher in dogs with IVDD before and after surgery. Analysis of these data suggests that dogs with IVDD are in a state of oxidative stress and that preemptive treatment with antioxidants warrants further investigation.  相似文献   

A plea for justice for jailed medical workers     

Ahuja SK  Aiuti F  Berkhout B  Biberfeld P  Burton DR  Colizzi V  Deeks SG  Desrosiers RC  Dierich MP  Doms RW  Emerman M  Gallo RC  Girard M  Greene WC  Hoxie JA  Hunter E  Klein G  Korber B  Kuritzkes DR  Lederman MM  Malim MH  Marx PA  McCune JM  McMichael A  Miller C  Miller V  Montagnier L  Montefiori DC  Moore JP  Nixon DF  Overbaugh J  Pauza CD  Richman DD  Saag MS  Sattentau Q  Schooley RT  Shattock R  Shaw GM  Stevenson M  Trkola A  Wainberg MA  Weiss RA  Wolinsky S  Zack JA 《Science (New York, N.Y.)》2006,314(5801):924-925

  相似文献   

The effect of three different doses of sodium pentosan polysulphate on haematological and haemostatic variables in adult horses     

AJ DART  N PERKINS  BA DOWLING  T BATTERHAM  C LIVINGSTON  DR HODGSON 《Australian veterinary journal》2001,79(9):624-627

OBJECTIVE: To evaluate the effects of three different doses of sodium pentosan polysulphate (PPS) on haematological and haemostatic variables in adult horses. DESIGN: Eight adult standardbred horses were used. All horses received a single injection of 0, 3, 6, and 10 mg/kg of PPS at the beginning of each treatment week for 4 weeks so that by the end of the study all horses had received all four doses of PPS. Blood samples were collected at 0, 1, 2, 3, 4, 6, 8, 12, 24, 48, and 168 h after each weekly injection of PPS. Variables measured were packed cell volume, haemoglobin, red blood cell count, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, platelet count, white cell count, neutrophil count, lymphocyte count, eosinophil count, monocyte count, serum protein, fibrinogen, prothrombin time, and activated partial thromboplastin time (PTT). Data were analysed using an ANOVA. Significance was set at P < 0.05. RESULTS: There was a dose-dependent increase in PTT. A significant increase in PTT occurrred in all treatment groups when compared to horses receiving 0 mg/kg in which there was no change over time. The PTT values all returned to baseline by 48 h after treatment. The mean neutrophil count was higher 3 h after treatment when compared to time 0. Horses receiving 3 mg/kg of PPS had a higher lymphocyte count 4 h after injection, and those receiving 6 and 10 mg/kg had higher counts at 3,4,6 and 8 h after injection when compared to time 0. At 8 h after injection horses receiving 6 and 10 mg PPS had higher lymphocyte counts than horses not receiving PPS. CONCLUSIONS: PPS causes a dose-dependent prolongation of PTT in horses. At the dose rates currently recommended for treatment of joint problems in horses this increase was small and remained elevated from baseline for up to 24 h. Based on these findings doses of PPS up to 3 mg/kg should not be administered to horses within 24 h of high stress activities or where physical injury may occur.  相似文献   

Removal of a cystic nasal concha from a bull     

RN HOOPER  J. SCHUMACHER  AJ ROUSSEL 《Australian veterinary journal》1997,75(9):641-642

  相似文献   

Indirect determination of nitric oxide in cats with cardiomyopathy and arterial thromboembolism     

Lisa M. Freeman DVM  PhD  DACVN    Maureen A. McMichael DVM  DACVECC    Armelle M. de Laforcade DVM  DACVECC    Elizabeth A. Rozanski DVM  DACVECC  DACVIM    Donald J. Brown DVM  PhD    John E. Rush DVM  MS  DACVECC  DACVIM 《Journal of Veterinary Emergency and Critical Care》2003,13(2):71-76

Objective: To determine nitric oxide concentration in cats with hypertrophic or intermediate forms of cardiomyopathy and arterial thromboembolism (ATE) compared to healthy controls and to determine the association between nitric oxide concentration and the presence of ATE, congestive heart failure (CHF), and echocardiographic measurements. Design: Case–control study. Setting: Veterinary teaching hospital. Animals: Client‐owned cats with cardiomyopathy, cardiomyopathy and ATE, and normal cats. Interventions: None. Measurements: All cats underwent 2‐dimensional and M‐mode echocardiography. Nitric oxide was assessed indirectly by measuring the concentration of plasma nitrite+nitrate (NN), end products of nitric oxide metabolism. Plasma arginine concentration and dietary arginine content were also assessed since arginine is a precursor for nitric oxide production. Main results: Twenty‐six cats with cardiomyopathy, 26 cats with cardiomyopathy and ATE, and 29 nor‐mal cats were enrolled. Compared with healthy controls, median NN concentration was significantly higher in cats with cardiomyopathy and cats with both cardiomyopathy and ATE. There was no difference between cats with cardiomyopathy alone and cats with cardiomyopathy and ATE. Nitrate+ nitrite concen‐tration in cats with cardiac disease was unrelated to the presence of CHF, plasma arginine concentration, or dietary arginine content. In cats with cardiac disease, the left atrial diameter, left ven‐tricular diameter in diastole, and age were negatively correlated with NN concentrations. Conclusions: Nitric oxide concentration is elevated in cats with cardiac disease, but the elevation appears to be independent of ATE and CHF.  相似文献   

The distribution and prevalence of Theileria buffeli in cattle in Queensland     

NP STEWART  NF STANDFAST†  FC BALDOCK‡  DJ REID  AJ de  VOS† 《Australian veterinary journal》1992,69(3):59-61

The distribution and prevalence of Thelleria buffeli in Queensland cattle were investigated using serum samples and blood films collected primarily for brucellosis surveillance and tick fever diagnosis. Serums from 8654 cattle from 357 farms throughout Queensland were examined by an indirect fluorescent antibody test for antibody to T buffeli. In addition, 347 peripheral blood films collected from 147 farms in south-eastern Queensland were examined for piroplasms of T buffeli. The overall herd and animal prevalences for T buffeli were 75% and 41%, respectively. There was significant variation among regions in both herd and animal prevalences (P less than 0.001). Herd and animal prevalences were highest in the north and east decreasing westward. The results indicate that T buffeli is more widespread in Queensland than previously thought.  相似文献   

Newcastle disease     

AJ DELLA-PORTA  T SPENCER† 《Australian veterinary journal》1989,66(12):424-426

  相似文献