Histamine, tyramine, tryptamine and electrolytes during glucose induced lactic acidosis.   总被引：1，自引：0，他引：1  

L N Irwin  G E Mitchell  R E Tucker  G T Schelling 《Journal of animal science》1979,48(2):367-374

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John Hunter (Part III)          下载免费PDF全文

Chas. A. Mitchell 《Canadian journal of veterinary research》1963,27(2):34-41

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A report of a natural outbreak of botulism in pheasants   总被引：1，自引：0，他引：1       下载免费PDF全文

Fish NA  Mitchell WR  Barnum DA 《The Canadian veterinary journal. La revue veterinaire canadienne》1967,8(1):10-16

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Ultrastructural demonstration of mitochondrial calcium overload in myocardial cells from broiler chickens with ascites and induced hypoxia   总被引：1，自引：0，他引：1  

M.H. Maxwell  G.W. Robertson  M.A. Mitchell 《Research in veterinary science》1993,54(3):367

Two groups of young broiler chickens, namely, naturally occurring field cases of ascites and those with an induced hypoxia, were used in an ultrastructural study to examine the localisation and distribution of intracellular Ca²⁺ in cardiomyocytes. Age-matched healthy flockmates were used to control each group. Deposits of Ca²⁺ were located extensively in the mitochondria, sarcoplasmic reticulum and Golgi apparatus and sometimes in the myocyte and endothelial cell nuclei of both groups of birds. The results suggest that the cells from the hearts of the ascitic broilers may have been exposed to hypoxia since a large proportion of control material showed no Ca²⁺ activity in either mitochondria or nuclei. The presence of a Ca²⁺ overload in the mitochondria of cardiomyocytes from ascitic birds reared at low altitude or sea level suggests that these broilers were suffering from the deleterious effects of chronic hypoxia due to poor or reduced oxygen use.  相似文献   

ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION USING A COMPOSITE COLLAGENOUS PROSTHESIS: A BIOMECHANICAL AND HISTOLOGIC STUDY IN RABBITS     

Dunn MG  Tria AJ  Kato YP  Bechler JR  Ochner RS  Zawadsky JP  Silver FH 《Veterinary surgery : VS》1993,22(1):56-56

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Cytotoxicity against autologous, allogeneic, and xenogeneic tumor targets by human recombinant interleukin-2-activated lymphocytes from healthy dogs and dogs with lung tumors     

D H Mitchell  S J Withrow  M R Johnston  C A Kruse 《American journal of veterinary research》1991,52(7):1132-1136

Before dogs with lung tumors were treated by adoptive immunotherapy, the ability of canine blood lymphocytes (PBL) from the peripheral circulation to differentiate in vitro in the presence of human recombinant interleukin-2 (rIL-2) and become tumoricidal was investigated. The PBL from healthy dogs (n = 6) and dogs with lung tumors (n = 5) were grown in culture medium alone, in the presence of rIL-2 to generate lymphokine-activated killer (LAK) cells, or with phytohemagglutinin (PHA) and rIL-2 to generate autologous-stimulated lymphocytes (ASL). After 4 days, cytotoxicity by the ASL, LAK, and PBL was determined in a 4-hour 51chromium-release assay. Target cells in the assay were short-term cultured enzyme digests of autologous (self), allogeneic (genetically different) primary tumors, and Raji, the xenogeneic human lymphoma cell line. The PBL cultured without rIL-2 were not cytotoxic against any tumor. However, when a dog's PBL were activated in vitro, they killed the dog's own tumor, ASL more effectively than LAK cells. Pulmonary adenocarcinomas and an osteosarcoma metastasis to lung were among the autologous tumors assayed. Against an allogeneic canine osteosarcoma, ASL generated from healthy dogs were significantly more cytolytic than LAK from healthy dogs, or than ASL generated from tumor-bearing dogs. Cytotoxicity was greater against allogeneic tumor than against Raji. Lectin-dependent cellular cytotoxicity, tested by including PHA in the assay medium with lymphocytes and Raji cells, by ASL and LAK was greater than cytotoxicity of Raji without PHA. Because ASL were more cytolytic than LAK against all targets in vitro, they may be more beneficial than LAK for immunotherapy of canine tumors.  相似文献   

Assessment of tetracycline and Babesia culture supernatant as prophylactics for moderating reactions in cattle to live Babesia and Anaplasma vaccines     

WK JORGENSEN  RE BOCK  TG KINGSTON  AJ DE VOS  SJ WALDRON 《Australian veterinary journal》1993,70(1):35-36

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Mesenteric tear of the distal jejunum as a periparturient complication in a mare     

AJ DART  JR PASCOE 《Australian veterinary journal》1994,71(12):427-428

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ALL WE CAN NEVER BE     

C. Mitchell 《The Journal of small animal practice》1987,28(7):549-550

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A biochemical profile for predicting the chronic exposure of sheep to Microscystis aeruginosa, an hepatotoxic species of blue-green alga     

C.R. Carbis  J.A. Simons  G.F. Mitchell  J.W. Anderson  I. McCauley 《Research in veterinary science》1994,57(3):561

Sheep which grazed on the shoreline of a freshwater lake which had a toxic bloom of Microcystis aeruginosa were studied for evidence of chronic poisoning, and a serum biochemical profile was developed to indicate sub-lethal, chronic poisoning in the sheep which had been exposed to microcystins. The profile included measurements of glutamate dehydrogenase (GLDH), γ-glutamyl transferase (γGT), bile acids, bilirubin and albumin. Of 18 sheep which were exposed to M aeruginosa for more than three months, 100 per cent had high serum concentrations of bile acids, 94 per cent had high activities of gldh and γgt, 83 per cent had high bilirubin and 72 per cent had low albumin concentrations compared with the median values of unexposed animals. Other sheep which were exposed for shorter periods, showed evidence of hepatic injury after one week of exposure. The majority of the sheep showed no preference for an alternative, uncontaminated source of water.  相似文献