Effects of administration of ascorbic acid and low-dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses     

Melinda J. Anderson  Alina S. Ibrahim  Bruce R. Cooper  Andrew D. Woolcock  George E. Moore  Sandra D. Taylor 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(6):2710-2718

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Three-dimensional bladder ultrasound for estimation of urine volume in dogs compared with traditional 2-dimensional ultrasound methods     

Allison Kendall  Erin Keenihan  Zachary T. Kern  Crystal Lindaberry  Adam Birkenheuer  George E Moore  Shelly L. Vaden 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(6):2460-2467

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A novel surgical technique for enucleation in rabbits to reduce the risk of intra‐ and post‐operative orbital hemorrhage     

Bret A. Moore  Jessica Robertson  Danielle K. Tarbert  Kathryn L. Good  Joanne R. Paul‐Murphy 《Veterinary ophthalmology》2020,23(2):409-413

A 10‐year‐old male castrated Holland Lop rabbit (Oryctolagus cuniculus) was presented for severe ulcerative stromal keratitis of the right eye and a luxated hypermature cataract and glaucoma of the left eye. Staged bilateral enucleation was elected. A LigaSure? electrosurgical bipolar vessel‐sealing device was used as a means to minimize intraoperative and post‐operative hemorrhage, especially that associated with the orbital venous plexus. The LigaSure? was used to ligate and transect all extraocular muscles, the optic nerve bundle, and the base of the third eyelid with no complications encountered. Overall, the LigaSure? was easy to use, resulted in minimal hemorrhage, and reduced surgery time. This is the first report of the use of a LigaSure? to aid in the enucleation of a rabbit. Although only positive results were achieved as an alternative to conventional methodologies, its use in clinical practice should be that of caution until a larger study evaluating the long‐term results is performed.  相似文献   

Reference values for selected ophthalmic diagnostic tests in two species of microchiroptera bats (Artibeus lituratus and Anoura caudifer)     

Andr Tavares Somma  Christiane M. Coimbra  Rogrio R. Lange  Bret A. Moore  Fabiano Montiani‐Ferreira 《Veterinary ophthalmology》2020,23(1):61-66

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Retrospective outcome evaluation for dogs with surgically excised,solitary Kiupel high‐grade,cutaneous mast cell tumours     

Antony S. Moore  Angela E. Frimberger  David Taylor  Neill Sullivan 《Veterinary and comparative oncology》2020,18(3):402-408

Published outcomes for dogs with specifically high‐grade mast cell tumours (MCTs), controlled for clinical stage, are few. Clinical outcomes for 49 dogs with Kiupel high‐grade, clinical stage I, cutaneous MCTs were evaluated. Median survival time (MST) was 1046 days; 1 and 2‐year survival rates were 79.3% and 72.9%, respectively. At study end 24 dogs had died, 23 dogs were alive (median follow‐up 980 days) and 2 dogs were lost to follow‐up. Death was considered MCT‐related in 14 of 20 dogs with a known cause of death. Local tumour recurrence developed in nine dogs (18.4%); regional lymph node metastasis occurred in six dogs (12.2%); and a new MCT developed in 15 dogs (30.1%). Tumour location, histologic margin size and use of chemotherapy did not affect MST; increasing mitotic count (P = .001) and increasing tumour diameter (P = .024) were independently negatively prognostic. Six dogs that developed lymph node metastasis after surgery had worse MST (451 days) than 42 dogs that did not develop metastasis (1645 days); (P < .001). Our study suggests that dogs with local surgical control of clinical stage I histologically high Kiupel grade cutaneous MCT may have a long survival time; especially those with smaller tumours and a lower mitotic count. Our results suggest that evaluation of staging information and mitotic count may be equally helpful as histologic grading when making a prognosis; and highlight the importance of not relying on histologic grade alone when predicting survival for dogs with MCT.  相似文献   

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy     

Ni Chonghaile T  Sarosiek KA  Vo TT  Ryan JA  Tammareddi A  Moore Vdel G  Deng J  Anderson KC  Richardson P  Tai YT  Mitsiades CS  Matulonis UA  Drapkin R  Stone R  Deangelo DJ  McConkey DJ  Sallan SE  Silverman L  Hirsch MS  Carrasco DR  Letai A 《Science (New York, N.Y.)》2011,334(6059):1129-1133

Cytotoxic chemotherapy targets elements common to all nucleated human cells, such as DNA and microtubules, yet it selectively kills tumor cells. Here we show that clinical response to these drugs correlates with, and may be partially governed by, the pretreatment proximity of tumor cell mitochondria to the apoptotic threshold, a property called mitochondrial priming. We used BH3 profiling to measure priming in tumor cells from patients with multiple myeloma, acute myelogenous and lymphoblastic leukemia, and ovarian cancer. This assay measures mitochondrial response to peptides derived from proapoptotic BH3 domains of proteins critical for death signaling to mitochondria. Patients with highly primed cancers exhibited superior clinical response to chemotherapy. In contrast, chemoresistant cancers and normal tissues were poorly primed. Manipulation of mitochondrial priming might enhance the efficacy of cytotoxic agents.  相似文献   

The pace of shifting climate in marine and terrestrial ecosystems   总被引：2，自引：0，他引：2  

Burrows MT  Schoeman DS  Buckley LB  Moore P  Poloczanska ES  Brander KM  Brown C  Bruno JF  Duarte CM  Halpern BS  Holding J  Kappel CV  Kiessling W  O'Connor MI  Pandolfi JM  Parmesan C  Schwing FB  Sydeman WJ  Richardson AJ 《Science (New York, N.Y.)》2011,334(6056):652-655

Climate change challenges organisms to adapt or move to track changes in environments in space and time. We used two measures of thermal shifts from analyses of global temperatures over the past 50 years to describe the pace of climate change that species should track: the velocity of climate change (geographic shifts of isotherms over time) and the shift in seasonal timing of temperatures. Both measures are higher in the ocean than on land at some latitudes, despite slower ocean warming. These indices give a complex mosaic of predicted range shifts and phenology changes that deviate from simple poleward migration and earlier springs or later falls. They also emphasize potential conservation concerns, because areas of high marine biodiversity often have greater velocities of climate change and seasonal shifts.  相似文献   

Pentaborate Polyanion in the Crystal Structure of Ulexite, NaCaB5O6(OH)6{middle dot}5H2O     

JR Clark  DE Appleman 《Science (New York, N.Y.)》1964,145(3638):1295-1296

Triclinic ulexite crystals contain isolated borate polyanions [B(5)O(6)(OH)(6)](3-) related to the well known pentaborate polyanion [B(5)O(6)(OH)(4)](-) by addition of two hydroxyl groups to two opposite B-O triangles. The isolated ulexite polyanions form the [B(5)O(7)(OH)(4)](n)(3n-) chains previously found in crystals of the related mineral probertite, NaCaB(5)O(7)(OH)(4).3H(2)O.  相似文献   

Errors in greenhouse forcing and soil carbon sequestration estimates in freshwater wetlands: a comment on Mitsch et al. (2013)   总被引：1，自引：0，他引：1  

Scott D. Bridgham  Tim R. Moore  Curtis J. Richardson  Nigel T. Roulet 《Landscape Ecology》2014,29(9):1481-1485

Radiative forcing feedbacks from wetlands have been an important component of past climate change and will likely be so in the future, so accurately assessing the carbon (C) and radiative balances of wetlands remains an important research priority. This commentary shows that the paper by Mitsch et al. (Landscape Ecol 28:583–597, 2013) seriously underestimated the radiative forcing effect of methane (CH₄) emissions and overestimated soil C sequestration in freshwater wetlands. The model that they used is flawed in double counting the atmospheric decay of CH₄ and incorporating a single 100 year CH₄ global warming potential. They also used a small number of sites and short-term soil dating that resulted in unrealistically high soil C sequestration rates, ignoring decay of the entire soil C pool and allochthonous inputs of C. They calculated the radiative balance instead of the radiative forcing of natural wetlands, making their calculations irrelevant to anthropogenic climate change. Irrespective of the radiative forcing of wetlands, they provide essential ecosystem services that are important to protect.  相似文献   

Ex vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency and the development of a thymic T cell lymphoma     

Kennedy DR  Hartnett BJ  Kennedy JS  Vernau W  Moore PF  O'Malley T  Burkly LC  Henthorn PS  Felsburg PJ 《Veterinary immunology and immunopathology》2011,142(1-2):36-48

We have previously shown that in vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency (XSCID) results in sustained T cell reconstitution and sustained marking in myeloid and B cells for up to 4 years with no evidence of any serious adverse effects. The purpose of this study was to determine whether ex vivo γ-retroviral gene therapy of XSCID dogs results in a similar outcome. Eight of 12 XSCID dogs treated with an average of dose of 5.8 × 10(6) transduced CD34(+) cells/kg successfully engrafted producing normal numbers of gene-corrected CD45RA(+) (na?ve) T cells. However, this was followed by a steady decrease in CD45RA(+) T cells, T cell diversity, and thymic output as measured by T cell receptor excision circles (TRECs) resulting in a T cell lymphopenia. None of the dogs survived past 11 months post treatment. At necropsy, few gene-corrected thymocytes were observed correlating with the TREC levels and one of the dogs was diagnosed with a thymic T cell lymphoma that was attributed to the gene therapy. This study highlights the outcome differences between the ex vivo and in vivo approach to γ-retroviral gene therapy and is the first to document a serious adverse event following gene therapy in a canine model of a human genetic disease.  相似文献