Intralesional cisplatin chemotherapy and topical cryotherapy for the control of choanal squamous cell carcinoma in an African penguin (Spheniscus demersus).     

Shannon T Ferrell  Annajane B Marlar  Michael Garner  Nancy P Lung 《Journal of zoo and wildlife medicine》2006,37(4):539-541

A 3.5-yr-old, 2.5-kg female African penguin (Spheniscus demersus) was diagnosed with a choanal squamous cell carcinoma on the basis of biopsy after a history of choanal ulceration and anorexia with weight loss. Therapeutic modalities included the use of intralesional cisplatin followed by localized, topical cryotherapy with liquid nitrogen. The penguin remained free of clinical disease for a period of 9 mo, at which time a second cryotreatment was performed. The patient has remained free of all signs of choanal carcinoma for a period of 13 mo since the second cryotreatment.  相似文献   

Oral eosinophilic granulomas in tigers (Panthera tigris)--a collection of 16 cases.     

John M Sykes  Michael M Garner  Leah L Greer  Nancy P Lung  Rob L Coke  Frank Ridgley  Mitch Bush  Richard J Montali  Ben Okimoto  Robert Schmidt  Jack L Allen  Bruce A Rideout  Patricia A Pesavento  Edward C Ramsay 《Journal of zoo and wildlife medicine》2007,38(2):300-308

Oral eosinophilic granulomas were diagnosed in 16 tigers (Panthera tigris). All lesions were located on the hard or soft palate and typically consisted of flat or slightly raised circular ulcers. Histologic features of these lesions were essentially identical to those seen in oral eosinophilic granulomas of domestic cats and dogs. No clinical signs were noted in eight cases, though various degrees of inappetence, excessive salivation, and dysphagia were noted in the other eight tigers. Six cases were not treated. Treatment for the remaining 10 cases centered on corticosteroids and additional treatments included surgical removal, cryotherapy, antibiotics, and chlorpheniramine. Treatment with corticosteroids did appear to be effective in some cases, though lesions would worsen after cessation of therapy and no cases were cured. In addition, three cases developed complications possibly related to this corticosteroid therapy. The etiology of these lesions remains unknown, though an underlying allergic condition is likely.  相似文献   

Baclofen intoxication in a dog successfully treated with hemodialysis and hemoperfusion coupled with intensive supportive care     

Nancy E. Scott  MS  DVM  DACVECC    Thierry Francey  Dr. med. vet.  DACVIM    Karl Jandrey  DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2007,17(2):191-196

Objective: To describe a case of confirmed baclofen intoxication in a dog that was successfully treated with hemodialysis and hemoperfusion (HD/HP) and to report the serum baclofen kinetics. Case summary: A 2.5‐year‐old, 23 kg, spayed female Brittany Spaniel‐mix was treated after ingesting 21‐52 mg/kg of baclofen. The dog was comatose and was receiving manual ventilation at the time of presentation. Extracorporeal HD/HP was started 10 hours after admission. Within 3 hours of starting HD/HP the dog began initiating breaths and was extubated 18 hours after admission. Serial serum samples that were obtained during the first 24 hours of hospitalization were later analyzed for baclofen concentrations. The dog had elevated creatine phosphokinase and liver enzymes that correlated with an agitated recovery period. The dog had thrombocytopenia that resolved by 10 days after presentation. New or unique information provided: HD/HP shortened the baclofen serum elimination half‐life from 5 to 1.5 hours in the initial 2 hours of treatment. The intrinsic elimination rate constant (K_intr) for this dog was 0.138/hour and the total elimination rate constant (K_tot) during the first 2 hours of HD/HP treatment was 0.458/hour. In this dog, HD/HP was an effective method for rapidly decreasing serum baclofen concentration after an acute overdose.  相似文献   

Nutrient cycling in two traditional Central American agroforestry systems     

Nancy Glover  John Beer 《Agroforestry Systems》1986,4(2):77-87

A preliminary nutrient cycling study quantified total and temporal nutrient inputs via litterfall and pruning residues in two agroforestry systems: (1) Coffea arabica (perennial crop)-Erythrina poeppigiana (leguminous shade tree); and (2) C. arabica-E. poeppigiana-Cordia alliodora with emphasis on the effect of the timber tree C. alliodora. The total annual input of litterfall plus pruning residues was similar in both associations. Total annual input from E. poeppigiana was less than half in the association with C. alliodora than without, but the litterfall from this latter species compensated for the loss. Large differences in the total annual nutrient input of K, Ca and Mg was found between associations, but not for N or P. The amount of nutrients recycled by the associated trees reached the recommended level of fertilizer required for coffee production. The inclusion of C. alliodora within the C. arabica-E. poeppigiana association resulted in a more evenly distributed annual nutrient input.  相似文献   

Response of <Emphasis Type="Italic">Pinus pseudostrobus</Emphasis> Lindl. to fertile growing medium and tephra-layer depth under greenhouse conditions     

Nancy Alejandre-Melena  Roberto Lindig-Cisneros  Cuauhtémoc Sáenz-Romero 《New Forests》2007,34(1):25-30

Major disturbances that remove vegetation cover create conditions that differ greatly from those in adjacent forests. In volcanic areas, tephra deposition can be a major disturbance that eliminates vegetation cover and creates a barrier for plant establishment. The eruption of the Paricutín volcano, in Michoacán, México, from 1943 to 1952, created large tephra deposits adjacent to forest stands. Many of these deposits still lack native vegetation and understanding of the limiting factors for establishment of native tree species is necessary to restore these areas. Pinus pseudostrobus early growth in response to the amount of fertile growing medium on top of a variable-depth tephra layer was evaluated in a greenhouse experiment. Increasing amounts of fertile growing medium increased height of 28-week-old plants (no growing medium = 5.5 cm tall ±1.8 cm, 3 cm of growing medium = 21.2 ± 4.6 cm and 6 cm of growing medium 24.8 ± 4.4 cm). Other variables showed the same trend (diameter, number of fascicles, belowground biomass and aboveground biomass). Our results suggest that P. pseudostrobus establishment in tephra covered areas will depend on the accumulation of a fertile layer of more than 3 cm in thickness.  相似文献   

Soybean mosaic virus Helper Component-Protease Alters Leaf Morphology and Reduces Seed Production in Transgenic Soybean Plants     

Lim HS  Ko TS  Hobbs HA  Lambert KN  Yu JM  McCoppin NK  Korban SS  Hartman GL  Domier LL 《Phytopathology》2007,97(3):366-372

ABSTRACT Transgenic soybean (Glycine max) plants expressing Soybean mosaic virus (SMV) helper component-protease (HC-Pro) showed altered vegetative and reproductive phenotypes and responses to SMV infection. When inoculated with SMV, transgenic plants expressing the lowest level of HC-Pro mRNA and those transformed with the vector alone initially showed mild SMV symptoms. Plants that accumulated the highest level of SMV HC-Pro mRNA showed very severe SMV symptoms initially, but after 2 weeks symptoms disappeared, and SMV titers were greatly reduced. Analysis of SMV RNA abundance over time with region-specific probes showed that the HC-Pro region of the SMV genome was degraded before the coat protein region. Transgenic soybean plants that expressed SMV HC-Pro showed dose-dependent alterations in unifoliate leaf morphologies and seed production where plants expressing the highest levels of HC-Pro had the most deformed leaves and the lowest seed production. Accumulation of microRNAs (miRNAs) and mRNAs putatively targeted by miRNAs was analyzed in leaves and flowers of healthy, HC-Pro-transgenic, and SMV-infected plants. Neither expression of SMV HC-Pro nor SMV infection produced greater than twofold changes in accumulation of six miRNAs. In contrast, SMV infection was associated with twofold or greater increases in the accumulation of four of seven miRNA-targeted mRNAs tested.  相似文献   

Survival of a Patient With Tetanus in Bhutan Using a Magnesium Infusion Managed Only by Clinical Signs     

Kuenza P. Wangmo  Margie Teng  Richard Henker  Stephen Kinnear  Jampel Tshering  Nancy E. Wang 《The Forestry Chronicle》2014,25(2):194-197

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Patterns in seabird distribution west of Scotland     

Nancy M. Harrison  Andy Webb  Genevieve M. Leaper 《水产资源保护:海洋与淡水生态系统》1994,4(1):21-30

The distribution of seabirds west of Scotland was studied relative to water masses in August 1988. Surface salinity was used to indicate the ship's position relative to the water masses described in the literature. Comparisons were made between seabird densities in Inshore Water, the Northern Coastal Current, the Southern Coastal Current and Atlantic/Hebridean Water. Seabird density varied with water mass; some species distributions suggested strong habitat associations. Water masses represent marine habitats, with different physical regimes supporting different marine life; patterns in bird distribution are likely to reflect prey distribution and availability. Manx shearwaters Puffinus puffinus, razorbills Alca torda, guillemots Uria aalge, and kittiwakes Rissa tridactyla were found mostly in Inshore Water, with lower densities in the Northern and Southern Coastal Current water. Only trace numbers of these species occurred in Atlantic/Hebridean Water. Storm petrels Hydrobates pelagicus, fulmars Fulmarus glacialis and puffins Fratercula arctica were found in very low densities in Inshore Water, and were dispersed in higher densities throughout the more oceanic areas. These data suggest that in late summer the Inshore Water of southwestern Scotland has the highest densities of seabirds potentially vulnerable in the event of an oil incident.  相似文献   

The Value of Seed Potatoes from Four Systems in Kenya     

Wachira Kaguongo  Gladys Maingi  Ian Barker  Nancy Nganga  Joseph Guenthner 《American Journal of Potato Research》2014,91(1):109-118

Although potatoes are the second most valuable crop in Kenya, poor seed potato quality has limited industry expansion. The objectives of this study were to describe the seed potato system, identify problems, determine use of high-quality seed and estimate farmer willingness to pay (WTP) for different types of seed. Data was collected from interviews, forums and surveys. A contingent valuation method (CVM) model was also developed to analyze the factors that influence farmer WTP. It was found that the seed system consists of three sub-components: Formal, Semi-Formal and Farmer. More than 96 % of Kenya seed potatoes were produced in the Farmer category, and were considered to be poor quality. Growers identified bacterial wilt, viral diseases and late blight as the most serious problems. The WTP model revealed that farmer age, distance to seed source, potato training, gender and region were statistically significant explanatory variables. The study recommends that training be conducted to increase production of “clean seed” and “positively-selected seed” in the Semi-Formal part of the seed system.  相似文献   

Tricyclic Guanidine Alkaloids from the Marine Sponge Acanthella cavernosa that Stabilize the Tumor Suppressor PDCD4     

Tanja Grkovic  Johanna S. Blees  Magdalena M. Bayer  Nancy H. Colburn  Cheryl L. Thomas  Curtis J. Henrich  Megan L. Peach  James B. McMahon  Tobias Schmid  Kirk R. Gustafson 《Marine drugs》2014,12(8):4593-4601

A cell-based high-throughput screen that assessed the cellular stability of a tumor suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine-containing marine alkaloid mirabilin K (3), as well as the known compounds mirabilin G (1) and netamine M (2). The structures of these tricyclic guanidine alkaloids were established from extensive spectroscopic analyses. Compounds 1 and 2 inhibited cellular degradation of PDCD4 with EC₅₀ values of 1.8 μg/mL and 2.8 μg/mL, respectively. Mirabilin G (1) and netamine M (2) are the first marine natural products reported to stabilize PDCD4 under tumor promoting conditions.  相似文献