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71.
Fleming DG Arseneau DJ Sukhorukov O Brewer JH Mielke SL Schatz GC Garrett BC Peterson KA Truhlar DG 《Science (New York, N.Y.)》2011,331(6016):448-450
The neutral muonic helium atom may be regarded as the heaviest isotope of the hydrogen atom, with a mass of ~4.1 atomic mass units ((4.1)H), because the negative muon almost perfectly screens one proton charge. We report the reaction rate of (4.1)H with (1)H(2) to produce (4.1)H(1)H + (1)H at 295 to 500 kelvin. The experimental rate constants are compared with the predictions of accurate quantum-mechanical dynamics calculations carried out on an accurate Born-Huang potential energy surface and with previously measured rate constants of (0.11)H (where (0.11)H is shorthand for muonium). Kinetic isotope effects can be compared for the unprecedentedly large mass ratio of 36. The agreement with accurate quantum dynamics is quantitative at 500 kelvin, and variational transition-state theory is used to interpret the extremely low (large inverse) kinetic isotope effects in the 10(-4) to 10(-2) range. 相似文献
72.
Preparations of erythrocyte glucose-6-phosphate dehydrogenase from normal individuals show similar degrees of inhibition by neutral salts. Preparations from Caucasian subjects with different hereditary deficiency syndromes differ from each other and from normal subjects, indicating a qualitative difference in these specific "deficient" enzymes. Sensitivity to neutral salts may be a means of detecting an amino acid substitution. 相似文献
73.
Global climate change poses an immense challenge for conservation biologists seeking to mitigate impacts to species and ecosystems. Species persistence will depend on geographic range shifts or adaptation in response to warming patterns as novel climates and community assemblages arise. Assisted colonization has been proposed as a method for addressing these challenges. This technique, which consists of transporting species to a new range that is predicted to be favorable for persistence under future climate scenarios, has become the subject of controversy and discussion in the conservation community due to its highly manipulative nature, questions about widespread feasibility, and uncertainty associated with the likelihood of translocated species becoming invasive. We reviewed the discussion and criticism associated with assisted colonization and sought to identify other conservation techniques that also display potential to promote the colonization and adaptation of species in response to climate change. We propose an integrated conservation strategy that includes management for habitat connectivity, conservation genetics, and when necessary, assisted colonization of species that are still unable to shift their ranges even given implementation of the above standard conservation approaches. We argue that this integrated approach will facilitate persistence for a larger proportion of species than is possible by solely using assisted colonization. Furthermore, a multi-faceted approach will likely reduce the uncertainty of conservation outcomes and will become increasingly necessary for conservation of biodiversity in a changing climate. 相似文献
74.
A 17-month-old cat presented for frequent swallowing, occasional cough and stertor. Radiographic evaluation revealed a soft tissue mass at the level of the soft palate. Oral examination revealed a soft tissue mass within the soft palate. Surgical resection was performed. Histopathology was consistent with a large developmental cyst. Following surgical management the cat has remained clinically free of signs for 2 months. 相似文献
75.
Carroll GL Narbe R Kerwin SC Taylor L Peterson K Hartsfield SM 《Veterinary anaesthesia and analgesia》2011,38(4):394-406
ObjectiveTo determine the lowest efficacious dose of oral meloxicam for relieving pain in cats with a sodium urate (SU)-induced acute inflammatory synovitis.Study designRandomized, blinded, controlled, and four-way crossover study.AnimalsEight surgically neutered cats (four males, four females) paired according to sex.MethodsEach pair of cats was treated with 0 (placebo), 0.025, 0.05, or 0.075 mg kg?1 oral meloxicam once daily for 4 days prior to injection, into alternating stifles, of 1 mL of 20 mg mL?1 SU crystals, beginning with the right stifle. Each cat received each of the four treatments, separated by at least 21 days. Analgesic efficacy was evaluated based on objective (e.g., pressure mat data total force, contact pressure, and contact area) and subjective (e.g., scores for Analgesia Scale [AS], Lameness Scale [LS], and Visual Analog Scale [VAS]) outcome measures for pain assessment. All outcome measures were recorded before and during 30 hours after SU injection. The pre-defined primary outcome measure was the area under the response–time curve (AUC0–30 hours) of the total force of the injected limb. Data were analyzed by analysis of variance. A sequential test procedure was applied and the test sequence stopped in case of a nonsignificant result.ResultsMeloxicam at doses of 0.05 and 0.075 mg kg?1 day?1 PO was significantly different from placebo for the pre-defined primary outcome measure (i.e., AUC0–30 hours of total force). All tested meloxicam doses were lower than placebo for the subjective outcome measures (i.e., AUC0–30 hours of AS, LS, and VAS).Conclusions and clinical relevanceThe lowest efficacious dose of meloxicam for relieving pain in cats with an SU-induced synovitis was 0.05 mg kg?1 day?1 PO according to the pre-defined primary outcome measure. However, lower doses may also be effective as seen in the subjective outcome measures. 相似文献
76.
Genetic diversity within a range of cultivars and landraces of flax (Linum usitatissimum L.) as revealed by RAPDs 总被引:1,自引:0,他引:1
Yong-Bi Fu Axel Diederichsen K.W. Richards Gregory Peterson 《Genetic Resources and Crop Evolution》2002,49(2):167-174
Analysis of the extent and distribution of genetic diversity incrop plants is essential for optimizing sampling and breedingstrategies. We used random amplified polymorphic DNA (RAPD)markers to assess genetic diversity and relationships in 22 Canadiancultivars, 29 selected world cultivars and 10 landraces of flax(Linum usitatissimum L.). RAPDvariation was generally low and more variation was detected among,than within, the investigated flax accessions. Based on 53 variableRAPD loci observed for the 61 accessions, the landraces had a lowerproportion of fixed recessive RAPD loci (0.427) (i.e.,more genetic variation) than all of the flax cultivars examined(0.492). The linseed cultivars had a lower proportion ofrecessive loci (0.469) than the fiber flax cultivars(0.529). Canadian linseed cultivars had a lower proportionof recessive loci (0.465) than the selected world flaxcultivars (0.512). A trend was also observed that the rateof loss in genetic variation in Canadian flax breeding programs overthe last fifty years was approximately two variable loci per 100 lociper 10 years. Clustering analyses based on similarity estimatesshowed that the fiber cultivars were more related (or similar toeach other) and were classified as a homogeneous group. All ofthe linseed cultivars were clustered in diverse groups with the ninelandrace accessions. Implications of these findings for flax breedingand germplasm management are discussed. 相似文献
77.
C. Grenier P.J. Bramel J.A. Dahlberg A. El-Ahmadi M. Mahmoud G.C. Peterson D.T. Rosenow G. Ejeta 《Genetic Resources and Crop Evolution》2004,51(5):489-500
Sorghum [Sorghum
bicolor (L.) Moench] is a very important crop in the Sudan serving as a primary source of food, beverage, and total livelihood for millions of people in the country. The crop originated in the Northeast quadrant of Africa, and the Sudan is widely recognized as a major center of diversity. Although Sudanese sorghum germplasm has been assembled and stored over the last 50 years, careful analysis of this valuable germplasm has not been made. The objectives of this study were to assess phenotypic diversity and compare pattern of distribution among Sudanese sorghum landraces collected from different geographical regions. Phenotypic diversity among landraces was high, as expressed by the large range of variation for mean quantitative traits and the high (0.81) Shannon-Weaver diversity index. Landraces from Gezira-Gedarif tended to be shorter in stature, earlier in maturity and less sensitive to changes in photoperiod. They also had long, narrow and compact panicles that may result from adaptation to low rainfall and early adoption of mechanized farming practices. In contrast, taller and later maturing plant types characterized sorghums from Equatoria, most of which delayed their flowering in response to increased day-length. These sorghums included many genotypes with small and light kernels. Collections from Kassala showed a higher frequency of landraces with kernels that were more difficult to thresh. Landraces from Blue Nile tended to have greater agronomic eliteness with higher proportion of landraces with white kernels, poorly covered and that were easy to thresh. Sorghums from the Upper Nile tended to have loose panicles with poorly covered kernels that may result from adaptation to high rainfall of the Southern region. Although distinct distributions of types were represented by geographical origin, a high level of within-region diversity was present among all Sudanese sorghums. 相似文献
78.
Fernando Machado-Stredel Benedictus Freeman Daniel Jiménez-Garcia Marlon E.Cobos Claudia Nu?ez-Penichet Laura Jiménez Ed Komp Utku Perktas Ali Khalighifar Kate Ingenloff Walter Tapondjou Thilina de Silva Sumudu Fernando Luis Osorio-Olvera A.Townsend Peterson 《中国鸟类》2022,(1):1-10
Studies of biodiversity dynamics have been cast on either long(systematics)or short(ecology)time scales,leaving a gap in coverage for moderate time scales of de... 相似文献
79.
Tarla Rai Peterson 《Agriculture and Human Values》1990,7(1):9-19
American agrarianism, as informed by the frontier myth, has provided fundamental inventional resources for agricultural rhetoric. These myths have deflected farmers from positive adaptation, reinforcing instead the self-image of a hero victimized by circumstances. Critical examination of these independent myths reveals their literalized status as well as inconsistencies with fundamental agricultural goals. 相似文献
80.
Triiodothyronine (T3) suppression test. An aid in the diagnosis of mild hyperthyroidism in cats 总被引:2,自引:0,他引:2
M E Peterson T K Graves D A Gamble 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1990,4(5):233-238
The purpose of this study was to develop a T3 suppression test to help in the diagnosis of mild hyperthyroidism in cats. We evaluated the response in circulating T4 concentrations to exogenous T3 (liothyronine) administration in 44 clinically normal cats, 77 cats with hyperthyroidism, and 22 cats with nonthyroidal disease. The test was performed by first collecting blood samples for basal serum T4 and T3 determinations, administering liothyronine at an oral dosage of 25 micrograms three times daily for seven doses, and, on the morning of the third day, again collecting serum samples for T4 and T3 determinations 2 to 4 hours after the seventh dose of liothyronine. The mean basal serum concentrations of T4 (53.1 nmol/L) and T3 (1.8 nmol/L) were significantly higher in the cats with hyperthyroidism than in the normal cats (T4 = 25.3 nmol/L, T3 = 1.3 nmol/L) and the cats with nonthyroidal disease (T4 = 29.5 nmol/L, T3 = 1.4 nmol/L); however, there was a great deal of overlap of basal values between the three groups of cats. Of the 77 cats with mild hyperthyroidism, 41 (53%) had serum T4 values and 55 (71%) had T3 values that were within the established normal ranges. After administration of liothyronine, mean serum T4 concentrations fell much more markedly in the normal cats and the cats with nonthyroidal disease than in the hyperthyroid cats.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献