Interleukin-8 as a prognostic serum marker in canine mammary gland neoplasias     

Gelaleti GB  Jardim BV  Leonel C  Moschetta MG  Zuccari DA 《Veterinary immunology and immunopathology》2012,146(2):106-112

Mammary gland tumors in female dogs are an excellent model for the clinic-pathological, diagnostic and prognostic investigation of mammary neoplasias. Prognostic and predictive markers are effective in research and routine diagnosis. Interleukins play a fundamental role in cancer, with a particular function in tumor growth, invasion and metastatic potential. Interleukin-8 (IL-8) is known to possess tumorigenic and pro-angiogenic properties, and its overexpression is seen in a number of human tumors. IL-8 serum levels were determined and correlated with the clinic-pathological features and clinical evolution of mammary gland neoplasias in female dogs. IL-8 was measured by an immunoenzymatic assay in 30 female dogs with mammary neoplasias within a 12 month follow-up and in 50 control animals. The correlation between IL-8 concentration and clinical parameters was investigated. A statistically significant difference in the IL-8 serum levels was found in tumor-bearing dogs compared to the controls. In addition, when the individual parameters were evaluated, IL-8 content showed a positive correlation with the tumor progression, lymph node involvement, recurrence and death. Single and multivariate analyses showed associations between tumor recurrence, metastasis, high clinical staging and high IL-8, and also with the death risk. This was also consistent with the high IL-8 content in dogs showing tumor recurrence and metastasis. IL-8 superexpression has been detected in a number of human tumors, usually associated with a poor prognostic. Besides promoting angiogenesis, IL-8 is strongly related with the metastatic phenotype of mammary tumor cells. High IL-8 concentration was found in mammary gland cancer patients with advanced disease stages. Our results show that IL-8 can be used as a non-invasive prognostic marker for mammary gland cancer, and can be useful for the prediction of disease progression and recurrence in dogs with mammary neoplasias. The increased level of this cytokine acts as an independent prognostic marker of survival and the identification of animals with the poor prognostic.  相似文献   

Mammary invasive micropapillary carcinoma in a male cat: Immunohistochemical description and clinical follow-up     

Gregório H  Pires I  Seixas F  Queiroga F 《Acta veterinaria Hungarica》2012,60(2):257-261

We describe the case of a 14-year-old Domestic Short Hair male cat that presented with a single mammary tumour one centimetre in diameter, classified as invasive micropapillary carcinoma. Histology and immunohistochemistry revealed a high mitotic index, a KI-67 index of 10%, a lack of reactivity to myoepithelial markers, and a dense infiltration with T and B lymphocytes at the periphery of the tumour. Micrometastases were detected in the regional lymph node at the time of surgery. Overall survival time was 10 months with a disease-free interval of 7.5 months. Distant metastases in the sublumbar lymph nodes confirmed the aggressiveness of this tumour, which has recently been subtyped in female cats. This is the first case reported in male cats with a complete follow-up, highlighting the importance of prompt and aggressive treatment in the presence of mammary tumours in male cats.  相似文献   

Preliminary results using a new container for cooled stallion semen transport     

A.C. Maciel  F.S. Castro  A. Pires Neves  R.C. Mattos  S. Fiala Rechsteiner 《Journal of Equine Veterinary Science》2012

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Effect of Freeze-Dried Red Beet (Beta vulgaris L.) Leaf Supplementation on Biochemical and Anthropometrical Parameters in Overweight and Obese Individuals: a Pilot Study     

de Castro  Ana Paula Ribeiro Barcelos  da Cunha  Diogo Thimoteo  Antunes  Adriane Elisabete Costa  Corona  Ligiana Pires  Bezerra  Rosângela Maria Neves 《Plant foods for human nutrition (Dordrecht, Netherlands)》2019,74(2):232-234

Plant Foods for Human Nutrition - Obesity is an important public health concern and is directly related with chronic noncommunicable diseases that affect the health of millions of people around the...  相似文献   

Estimating the level of disease risk and biosecurity on commercial poultry farms in New Zealand     

SS Greening  K Mulqueen  TG Rawdon  NP French  MC Gates 《New Zealand veterinary journal》2020,68(5):261-271

ABSTRACT

Aims: To collect baseline data on the contact risk pathways and biosecurity practices of commercial poultry farms in New Zealand, investigate the relationship between the farm-level disease contact risks and biosecurity practices, and identify important poultry health concerns of producers.

Methods: A cross-sectional survey of all registered New Zealand commercial poultry operations was conducted in 2016 collecting information on farm demographics, biosecurity practices, and contact risk pathways. Survey responses were used to generate an unweighted subjective disease risk score based on eight risk criteria and a subjective biosecurity score based on the frequency with which producers reported implementing seven biosecurity measures. Producer opinions towards poultry health issues were also determined.

Results: Responses to the survey response were obtained from 120/414 (29.0%) producers, including 57/157 (36.3%) broiler, 33/169 (19.5%) layer, 24/55 (44%) breeder, and 6/32 (19%) other poultry production types. Median disease risk scores differed between production types (p?<?0.001) and were lowest for breeder enterprises. The greatest risk for layer and broiler enterprises was from the potential movement of employees between sheds, and for breeder enterprises was the on- and off-farm movement of goods and services. Median biosecurity scores also differed between production types (p?<?0.001), and were highest for breeder and broiler enterprises. Across all sectors there was no statistical correlation between biosecurity scores and disease risk scores. Producers showed a high level of concern over effectively managing biosecurity measures.

Conclusions: The uptake of biosecurity measures in the commercial poultry farms surveyed was highly variable, with some having very low scores despite significant potential disease contact risks. This may be related to the low prevalence or absence of many important infectious poultry diseases in New Zealand leading farmers to believe there is a limited need to maintain good biosecurity as well as farmer uncertainty around the efficacy of different biosecurity measures. Further research is needed to understand barriers towards biosecurity adoption including evaluating the cost-effectiveness of biosecurity interventions.  相似文献   

E-cadherin expression in canine cutaneous histiocytoma     

Pires I  Alves A  Rodrigues P  Queiroga FL  Lopes CS 《The Veterinary record》2008,163(2):59-60; author reply 60

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Are complex carcinoma of the feline mammary gland and other invasive mammary carcinoma identical tumours? Comparison of clinicopathologic features,DNA ploidy and follow up     

Seixas F  Palmeira C  Pires MA  Lopes C 《Research in veterinary science》2008,84(3):428-433

Feline mammary carcinomas are known for their unfavourable prognosis due to a strong tendency to local recurrence and metastasis. We studied 73 spontaneous primary mammary carcinomas and identified eight cases presenting a biphasic nature, with neoplastic epithelial and myoepithelial cells (complex carcinoma). These cases presented histopathologic features associated with a better prognosis; they were also associated with higher overall survival and disease-free survival rates compared to other common invasive mammary carcinomas of non-specified type. Complex carcinoma appears to be a low-grade malignancy.  相似文献   

The phenotypic relationship between residual intake and gain and other feed efficiency traits in Nellore cattle     

de Figueiredo  Darcilene Maria  Mercadante  Maria Eugênia Zerlotti  Pires  Aldrin Vieira  Branco  Renata Helena  Ribeiro  Enilson Geraldo  Dallago  Gabriel Machado  Schorer  Marianne  Rocha  Pedro Ribeiro 《Tropical animal health and production》2019,51(2):449-456

This study aimed to compare feed efficiency measures of Nellore beef cattle on different residual intake and gain (RIG) classes. We used data from 610 animals weighing on average 236.33 kg and average of 283 days of age from feedlot performance tests carried out between 2005 and 2012. Animals were grouped based on RIG into three different classes: high RIG (>?mean?+?0.5 standard deviation (SD), most efficient; n?=?193), medium RIG (mean?±?0.5 SD; n?=?235), and low RIG (<?mean – 0.5 SD, least efficient; n?=?182). Residual feed intake (RFI), residual gain (RG), feed conversion ratio (FCR), feed efficiency (FE), relative growth rate (RGR), and Kleiber ratio (KR) of animals in each RIG class were compared by Tukey test at 1% of probability. Phenotypic correlations between variables were evaluated as well. Animals on high RIG class showed lower dry matter intake (P?<?0.01) and higher average daily gain (P?<?0.01) than low RIG animals. Consequently, high RIG animals had lower FCR (P?<?0.01) and higher FE (P?<?0.01) than those animals in low RIG class. The most efficient animals based on RIG were also the most efficient animals based on RG and RFI. RIG was negatively correlated to dry matter intake (P?<?0.01) and FCR (P?<?0.01), and a positive correlation was found between RIG and FE (P?<?0.01). Therefore, RIG appears to be a good parameter to select animals with reduced dry matter intake and high productive performance.

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Soil physical quality of a Brazilian Oxisol under two tillage systems using the least limiting water range approach   总被引：2，自引：0，他引：2  

Cassio Antonio Tormena  Alvaro Pires da Silva  Paulo Leonel Libardi 《Soil & Tillage Research》1999,52(3-4):223-232

Plant growth is directly affected by soil water, soil aeration, and soil resistance to root penetration. The least limiting water range (LLWR) is defined as the range in soil water content within which limitations to plant growth associated with water potential, aeration and soil resistance to root penetration are minimal. The LLWR has not been evaluated in tropical soils. Thus, the objective of the present study was to evaluate the LLWR in a Brazilian clay Oxisol (Typic Hapludox) cropped with maize (Zea mays L. cv. Cargil 701) under no-tillage and conventional tillage. Ninety-six undisturbed soil samples were obtained from maize rows and between rows and used to determine the water retention curve, the soil resistance curve and bulk density. The results demonstrated that LLWR was higher in conventional tillage than in no-tillage and was negatively correlated with bulk density for values above 1.02 g cm⁻³. The range of LLWR variation was 0–0.1184 cm³ cm⁻³ in both systems, with mean values of 0.0785 cm³ cm⁻³ for no-tillage and 0.0964 cm³ cm⁻³ for conventional tillage. Soil resistance to root penetration determined the lower limit of LLWR in 89% of the samples in no-tillage and in 46% of the samples in conventional tillage. Additional evaluations of LLWR are needed under different texture and management conditions in tropical soils.  相似文献   

Morphological evaluation of cardoon (<Emphasis Type="Italic">Cynara cardunculus</Emphasis> L.): assessing biodiversity for applications based on tradition,innovation and sustainability     

P. Barracosa  J. Oliveira  M. Barros  E. Pires 《Genetic Resources and Crop Evolution》2018,65(1):17-28

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