Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome     

Ikonomidou C  Bittigau P  Ishimaru MJ  Wozniak DF  Koch C  Genz K  Price MT  Stefovska V  Hörster F  Tenkova T  Dikranian K  Olney JW 《Science (New York, N.Y.)》2000,287(5455):1056-1060

The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade of N-methyl-D-aspartate (NMDA) glutamate receptors and excessive activation of GABA(A) receptors], triggers widespread apoptotic neurodegeneration in the developing rat forebrain. Vulnerability coincides with the period of synaptogenesis, which in humans extends from the sixth month of gestation to several years after birth. During this period, transient ethanol exposure can delete millions of neurons from the developing brain. This can explain the reduced brain mass and neurobehavioral disturbances associated with human fetal alcohol syndrome.  相似文献   

Smog aerosol: infrared spectra     

E R Stephens  M A Price 《Science (New York, N.Y.)》1970,168(939):1584-1586

Infrared spectra of smog aerosol are similar to those of sulfuric acid aerosol, but they do not show the prominent CH and carbonyl bands of organic aerosols from terpenes. Some features of the smog aerosol spectra are not present in the spectra from either type of synthetic aerosol.  相似文献   

Measurement of corneal sensitivity in 20 ophthalmologically normal alpacas     

Welihozkiy A  Bedenice D  Price LL  Pizzirani S  Pirie CG 《Veterinary ophthalmology》2011,14(5):333-336

Objective To determine corneal sensitivity in 20 healthy adult alpacas (40 eyes) in order to establish reference values. Design Prospective study. Animals Twenty healthy, adult alpacas. Procedures Corneal sensitivity was determined by the corneal touch threshold (CTT) using a Cochet‐Bonnet esthesiometer. Five different regions of the cornea were evaluated (nasal, ventral, lateral, dorsal, and central). Results Corneal touch threshold values (in mm filament length) obtained from five corneal regions demonstrated varying corneal sensitivities. The central region (34.5 ± 7.1 mm) was the most sensitive, followed by the ventral (29.5 ± 7.2 mm), medial (29.3 ± 7.3 mm), dorsal (25.6 ± 6.3 mm), and lateral (21.8 ± 5.7 mm) regions. All pairwise comparisons of regional differences were statistically significant (P < 0.05), except for the comparison between the ventral and medial regions (P = 0.88). Evaluation of the CCT while controlling for age (2–5 years vs. 6–10 years) demonstrated an increased CTT with an increasing age for the central, ventral, medial and lateral regions. A decrease in the CTT of the dorsal region was noted with increasing age. Conclusion and Clinical Relevance Corneal touch threshold values in 40 eyes of 20 healthy adult alpacas were determined using a Cochet‐Bonnet esthesiometer. This study demonstrated the central corneal region to be most sensitive. Values obtained may serve as reference values in subsequent studies.  相似文献   

Use of pimobendan in 170 cats (2006–2010)     

John M. MacGregor  John E. Rush  Nancy J. Laste  Rebecca L. Malakoff  Suzanne M. Cunningham  Natalie Aronow  Daniel J. Hall  Justin Williams  Lori L. Price 《Journal of Veterinary Cardiology》2011,13(4):251-260

Hypothesis/ObjectivesTo describe the therapeutic use of pimobendan in cats, describe the patient population to which it was administered, document potential side effects and report the clinical course following administration of pimobendan in conjunction with standard heart failure therapy. It is hypothesized that cats with advanced heart disease including congestive heart failure from a variety of causes will tolerate pimobendan with a minimum of side effects when used in treatment in conjunction with a variety of other medications.Animals, materials and methodsOne hundred and seventy client owned cats with naturally occurring heart disease, one hundred and sixty four of which had congestive heart failure. Medical records were reviewed and owners and referring veterinarians were contacted for follow-up data. Data collected included pimobendan dose, other medications administered concurrently, data collected at physical examination, presence or absence of heart failure, adverse effects, classification of heart disease, echocardiographic data and survival time. The data were analyzed for significance between the initial visit and any follow-up visits.ResultsAll cats were treated with pimobendan. The median pimobendan dose was 0.24 mg/kg q 12 h. Pimobendan was used in combination with multiple concurrent medications including angiotensin converting enzyme inhibitors, diuretics and anti-thrombotics. Five cats (3.0%) had potential side effects associated with pimobendan. One cat (0.6%) had presumed side effects severe enough to discontinue pimobendan use. Median survival time for 164 cats with congestive heart failure after initiation of pimobendan was 151 days (range 1–870).ConclusionPimobendan appears to be well tolerated in cats with advanced heart disease when used with a variety of concurrent medications. Randomized controlled studies need to be performed to accurately assess whether it is efficacious for treatment of congestive heart failure in cats.  相似文献   

A potentially useful distribution model for dietary intake data     

Myles JP  Price GM  Hunter N  Day M  Duffy SW 《Public health nutrition》2003,6(5):513-519

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Meiotic Response of In vitro Matured Canine Oocytes under Different Proteins and Heterologous Hormone Supplementation   总被引：2，自引：0，他引：2  

BA Rodrigues  JL Rodrigues 《Reproduction in domestic animals》2003,38(1):58-62

The impact of TCM‐199 supplemented with different proteins and heterologous hormones on the in vitro maturation (IVM) rate of bitch oocytes was evaluated by nuclear staining under fluorescence microscopy. Oocytes were recovered by slicing of ovaries from bitches presented at various stages of oestrous cycle to ovariohysterectomy. The basic culture medium was TCM‐199 supplemented with 25 mM Hepes/l, with 10% heat‐inactivated oestrous cow serum (ECS), 50 μg/ml gentamicin, 2.2 mg/ml sodium bicarbonate and 22‐μg/ml pyruvic acid, 1.0‐μg/ml oestradiol (E 8875; Sigma), 0.5‐μg/ml follicle‐stimulating hormone (FSH) (Folltropin‐V; Vetrepharm Inc., Ontario, Canada) and 0.03 IU/ml human gonadotropin (hCG) (Profasi HP; Serono, Aubonne, Switzerland). Oocytes were distributed randomly between basic culture medium (control) and the corresponding experimental treatment. Hormone treatments were: oocytes cultured in; (1) medium without FSH, (2) control medium supplemented with 20 μg/ml oestradiol, or (3) medium supplemented with 1 μg/ml human somatotropin (hST; Humatrope, Lilly, Saint Cloud, France). The second experiment consisted of oocytes cultured in medium supplemented with 0.4% (w/v) bovine serum albumin (BSA, fraction V; Gibco Grand Island, NY, USA) instead of ECS, or oocytes cultured in medium with 10% inactivated oestrous bitch serum (EBS) instead of ECS. Oocytes were cultured in 100 μl droplets (up to 25 oocytes per drop) under mineral oil at 37°C in a 100% humidified atmosphere containing 5% CO₂ in air. After 72 h of IVM, the highest rates (p < 0.05) of meiotic resumption were achieved with the 0.4% BSA supplementation. A positive influence on the metaphase II (MII) acquisition rate was observed with hST supplement. Oocytes cultured with 10% EBS supplementation did not develop to the MII stage. The results in this study show that the protein and hormone supplements to TCM‐199 culture medium tested did not promote the final steps of IVM of bitch oocytes.  相似文献   

The effects of selenium, housing and management on the incidence of pneumonia in housed calves   总被引：2，自引：0，他引：2  

M Phillippo  J R Arthur  J Price  G J Halliday 《The Veterinary record》1987,121(22):509-512

The occurrence and incidence of pneumonia in housed calves were not related to the selenium status of the herd as measured by blood glutathione peroxidase activity nor were they affected by selenium treatment of calves during the neonatal period. Pneumonia was related more closely to herd size and building design.  相似文献   

HYPOTHYROIDISM IN A DOG AFTER SURGERY AND RADIATION THERAPY FOR A FUNCTIONAL THYROID ADENOCARCINOMA     

Robert W.  Kramer  DVM  G. Sylvester  Price  DVM  Gary J.  Spodnick  DVM 《Veterinary radiology & ultrasound》1994,35(2):132-136

Hypothyroidism was diagnosed in a dog which had undergone unilateral thyroid lobectomy and external beam irradiation (48 Gy in 3 Gy fractions) for a functional cystic thyroid adenocarcinoma. Hypothyroidism became biochemically apparent within 4 months of completion of radiation therapy, and clinically apparent within 7 months. Clinical signs resolved after thyroid hormone supplementation. The potential for alterations in thyroid function should be considered in any animal undergoing radiation therapy in which the thyroid gland is included in the radiation field. This potential may be greater if surgery and radiation are combined.  相似文献   

Seasonal occurrence and distribution of Gasterophilus intestinalis and Gasterophilus nasalis in the stomachs of equids in Texas     

R E Price  P C Stromberg 《American journal of veterinary research》1987,48(8):1225-1232

Stomachs of 271 horses and ponies from 2 sources were evaluated for the presence of Gasterophilus intestinalis and G nasalis larvae, through 2 overlapping 12-month periods of bot fly activity in southern Texas. Equids (n = 140) from one source had nearly 96% of their stomachs infected, whereas equids (n = 131) from another source had 44% of their stomachs infected by Gasterophilus spp. Seasonal dynamics of the bot infection indicated the highest average number of bot larvae per infected stomach occurred in the winter and spring. The smallest average number of bots per infected stomach occurred in the fall. Higher percentages of early (2nd instar plus young 3rd instar) larvae of G intestinalis were observed in the fall in equids from both sources. The late (more fully developed older 3rd instar) G intestinalis larvae outnumbered the early larvae in the winter, spring, and summer. Seasonal variation in numbers and development status of the larvae was consistent with the largest period of adult bot fly activity occurring during the fall. The 2 species of bots had different predilection sites of attachment. Gasterophilus intestinalis larvae concentrated in the nonglandular portions of the stomach near the margo plicatus on the cranial (parietal) surface of the stomach and in the most dorsal extent of the saccus cecus. Gasterophilus nasalis larvae attached almost exclusively in the first ampulla of the duodenum. Predilection sites for both Gasterophilus spp occurred in dorsally positioned areas in the alimentary tract favoring increased availability of oxygen.  相似文献   

Consumer concern about animal health care     

D A Price 《Journal of the American Veterinary Medical Association》1972,160(5):673-675

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