Aetiology and diagnosis of persistent nasal disease in the dog: a retrospective study of 42 cases     

Tasker S  Knottenbelt CM  Munro EA  Stonehewer J  Simpson JW  Mackin AJ 《The Journal of small animal practice》1999,40(10):473-478

Forty-two dogs with a history of persistent nasal disease were evaluated by a combination of clinical examination, thoracic and nasal radiography, retroflexed endoscopy and biopsy, and anterograde rhinoscopy and blind nasal biopsy. A definitive diagnosis was made in 91 per cent of cases. Neoplasia was the most common diagnosis (33 per cent of cases), followed by inflammatory rhinitis (24 per cent). Other diagnoses included periodontal disease (10 per cent), aspergillosis (7 per cent) and foreign bodies (7 per cent). Adenocarcinoma was the most common tumour diagnosed. The clinical findings were found to be too variable to be used as specific diagnostic criteria. Anterograde rhinoscopy and retroflexed endoscopy had higher specificity and sensitivity than radiology for the diagnosis of neoplasia, inflammatory rhinitis, aspergillosis and foreign bodies. With a systematic approach to the investigation of persistent nasal disease, a definitive diagnosis can be successfully obtained in the vast majority of cases.  相似文献   

Abomasal secretion in sheep receiving adult Ostertagia circumcincta that are prevented from contact with the mucosa     

Simpson HV  Simpson BH  Simcock DC  Reynolds GW  Pomroy WE 《New Zealand veterinary journal》1999,47(1):20-24

AIMS: Both adult and larval Ostertagia circumcincta infections raise abomasal pH and serum gastrin and pepsinogen concentrations, either because of physical effects of the worms or from their chemical secretions. The study was designed to examine whether adult worms require contact with the gastric mucosa to effect changes in gastric secretion. METHODS: Abomasal pH and serum gastrin and pepsinogen concentrations were measured in four groups of sheep: Group A (n = 4): abomasal contents containing about 18,000 adult O. circumcincta were obtained from donor sheep, concentrated and infused into 5 microm mesh porous bags attached to surgically implanted abomasal cannulae. A second worm transplantation was carried out 1 week later to assess worm survival after 16 hours. Group B (n = 4): about 9000 adult worms, recovered after migration out of abomasal contents set in agar, were placed in small 5 microm mesh bags which were inserted through indwelling abomasal cannulae and left for 3 days. Group C (n = 2): about 3000 adult worms from the population recovered from agar were infused through abomasal cannulae which allowed. free movement in the abomasum. Group D (n = 3) was left uninfected. RESULTS: Worms transplanted directly into the abomasum (Group C) caused rapid and marked effects on abomasal secretion. Adult O. circumcincta died within 16 hours of transfer into the abomasum when they were restrained within porous bags. Nevertheless, in sheep receiving 18,000 worms, abomasal pH increased soon after new feed was presented on Days 1, 2 and 4 after worm transfer; serum gastrin was elevated in three sheep from 113 hours and serum pepsinogen increased in one animal. Sheep receiving 9000 worms showed similar trends but the results were equivocal. CONCLUSIONS: Adult O. circumcincta prevented from physical contact with the gastric mucosa by restraint in porous bags are able to raise abomasal pH. This study implicates parasite excretory-secretory products in mediating changes in gastric secretion caused by adult abomasal worms.  相似文献   

The effect of dose and line on immunisation of cattle with lymphoblastoid cells infected with Theileria annulata   总被引：1，自引：0，他引：1  

H Ouhelli  E A Innes  C G Brown  A R Walker  S P Simpson  R L Spooner 《Veterinary parasitology》1989,31(3-4):217-228

Thirty-one Friesian calves in Morocco susceptible to tropical theileriosis were protected against a lethal sporozoite challenge by prior infection with lymphoblastoid cell lines infected and transformed in vitro by a Moroccan stock of Theileria annulata. The challenge infection of cryopreserved sporozoites killed all four susceptible control calves within 20 days. Four schizont-infected cell cultures at Passage 3 were inoculated at four different doses, 10(8), 10(6), 10(4) and 10(2), into pairs of calves. The recipient animals showed great variation in severity of disease symptoms, which did not show a linear correlation with the cell dose inoculated. The most severe disease symptoms were recorded, prior to challenge, in the 10(2) cell dose recipients; one animal died of acute theileriosis and another had to be treated. One of the four cell lines used was more virulent than the other three. Two years after the completion of this experiment, immunised animals have shown normal productivity traits.  相似文献   

ULTRASONOGRAPHIC FINDINGS IN CHOLECYSTOKININ-INDUCED PANCREATITIS IN DOGS   总被引：1，自引：0，他引：1  

Christopher R.  Lamb  MA  VetMB  Kenneth W.  Simpson  BVM&S  PhD 《Veterinary radiology & ultrasound》1995,36(2):139-145

Pancreatitis can be induced in dogs by intravenous infusion of supraphysiologic doses of synthetic cholecystokinin octapeptide (CCK-8). Eight anesthetized female beagles were given either CCK-8 or saline in a randomized, blinded fashion and had abdominal ultrasonography to study the development of pancreatic lesions. Pancreatic lesions were apparent 2 hours after the start of CCK-8 infusion and included swelling, interlobular and subcapsular fluid accumulation and patchy hypoechogenicity of the gland parenchyma. CCK-8 had a variable effect on gallbladder emptying. No signs of biliary obstruction or duodenal lesions were identified. Dogs given CCK-8 had severe edematous pancreatitis at necropsy six hours after the start of the infusion. Compared to the oleic acid model of pancreatitis, CCK-8 infusion induces a rapid onset of pancreatitis and an ultrasonographic appearance that reflects diffuse edema of the gland. The short time-scale of the experiment may account for the relative absence of secondary lesions affecting the biliary tract or duodenum compared to the naturally-occurring disease.  相似文献   

Glomerulosclerosis in canine heartworm infection     

C F Simpson  B M Gebhardt  R E Bradley  R F Jackson 《Veterinary pathology》1974,11(6):506-514

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Drift theory: antarctica and central Asia     

Simpson GG 《Science (New York, N.Y.)》1970,170(3959):678

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Isolation of Edwardsiella tarda from an ostrich and an Australian skink   总被引：1，自引：0，他引：1  

F H White  F C Neal  C F Simpson  A F Walsh 《Journal of the American Veterinary Medical Association》1969,155(7):1057-1058

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Premature citations of zoological nomina     

G G Simpson 《Science (New York, N.Y.)》1968,161(836):75-76

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Further studies on the use of synthetic prostaglandin analogues for inducing luteolysis in mares   总被引：2，自引：0，他引：2  

W R Allen  F Stewart  M J Cooper  R C Crowhurst  D J Simpson  R J McEnery  R E Greenwood  P D Rossdale  S W Ricketts 《Equine veterinary journal》1974,6(1):31-35

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Effect of tilmicosin on chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages     

Brumbaugh GW  Herman JD  Clancy JS  Burden KI  Barry T  Simpson RB  López HS 《American journal of veterinary research》2002,63(1):36-41

OBJECTIVE: To evaluate chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages (AM) exposed to tilmicosin. ANIMALS: 12 healthy calves and 12 healthy pigs. PROCEDURES: Lungs were obtained immediately after euthanasia; AM were collected by means of bronchoalveolar lavage and density gradient centrifugation. Chemotactic activity was evaluated by exposing AM to lipopolysaccharide or macrophage inhibitory peptide during incubation with tilmicosin. Phagocytic activity was evaluated by incubating AM with tilmicosin for 24 hours and then with tilmicosin-resistant Salmonella serotype Typhimurium. Bactericidal activity was evaluated by incubating AM with tilmicosin (0, 10, or 20 microg/ml for bovine AM; 0 or 10 microg/ml or 10 microg/ml but washed free of tilmicosin for porcine AM) and then with Mannheimia haemolytica (bovine AM) or with Actinobacillus pleuropneumoniae or Pasteurella multocida (porcine AM). RESULTS: Tilmicosin had no significant effects on chemotactic or phagocytic activities of bovine or porcine AM. The time-course of bactericidal activity was best described by polynomial equations. Time to cessation of bacterial growth and area under the time versus bacterial number curve were significantly affected by incubation of AM with tilmicosin. CONCLUSIONS AND CLINICAL RELEVANCE: Results show that bactericidal activity of bovine and porcine AM was enhanced by tilmicosin, but not in proportion to the reported ability of AM to concentrate tilmicosin intracellularly. With or without exposure to tilmicosin, the time-course of bactericidal activity of bovine AM against M haemolytica and of porcine AM against A pleuropneumoniae or P multocida was too complex to be reduced to a simple linear equation.  相似文献