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991.
992.
993.
A ten-year-old miniature Dachshund dog was presented for chronic paroxysmal sneezing and unilateral nasal discharge. Extraction of the maxillary right fourth premolar tooth had been performed 2-weeks prior to the onset of clinical signs. Multiple diagnostic modalities were used to confirm the diagnosis and determine that the etiology was a nasally displaced mesiopalatal tooth root. A limited lateral rhinotomy was performed to remove the root. Postoperative examination 1-month following surgery indicated resolution of the clinical signs and uncomplicated healing of the surgery site. Oral examination indicated normal healing of the surgery site with continued absence of clinical signs 6-months after treatment. 相似文献
994.
Soto-Navarro SA Lawler TL Taylor JB Reynolds LP Reed JJ Finley JW Caton JS 《Journal of animal science》2004,82(6):1788-1793
Twelve crossbred steers (351 +/- 24 kg initial BW) were used to determine effects of high-Se wheat on visceral tissue mass, intestinal cell growth, and intestinal cellularity and vascularity. Steers were allotted randomly by BW to one of two treatments consisting of 75% concentrate diets that supplied 1) adequate Se concentration (7 to 12 microg x kg x BW(-1) x d(-1)) or 2) high-Se concentration (60 to 70 microg x kg x BW(-1) x d(-1)). Diets were similar in composition, including 25% grass hay, 25% wheat, 39% corn, 5% desugared molasses, and 6% wheat middlings supplement on a DM basis. In the Se treatment, high-Se wheat (10 ppm Se, DM basis) was replaced with low-Se wheat (0.35 ppm Se, DM basis). Diets were formulated to be similar in CP and energy (14.0% CP, 2.12 Mcal of NEm/kg, and 1.26 Mcal NEg/kg of DM) and were offered daily (1500) to individual steers in an electronic feeding system. Diets were fed at 2.38% BW. After 126 d, steers were slaughtered, and individual visceral tissue weights determined. Concentrations of DNA, RNA, and protein of duodenum, ileum, and total small intestine were not affected (P > or = 0.33) by treatment. Similarly, RNA:DNA and protein:DNA ratios in duodenum, jejunum, ileum, and whole small intestine were not (P > or = 0.33) affected by feeding high-Se wheat. Conversely, jejunal weight was greater (P < 0.002) in steers fed high-Se wheat than in controls (916 vs. 1,427 +/- 84 g). Jejunal DNA was increased (P < 0.04) in steers fed high-Se wheat (2.95 vs. 3.56 +/- 0.19 mg/g), suggesting increased cell number. Concentrations of jejunal RNA and protein were not altered by treatment; however, because the jejunal weight increased in high-Se steers, DNA, RNA, and protein contents (grams) were greater than in control steers (P < 0.05). Vascularity of jejunal tissue decreased (P < 0.10) with high-Se wheat; however, because jejunal mass was greater for the high-Se wheat treatment, total microvascular volume was not affected by treatment. Percentage of jejunal crypt cell proliferation was not affected (P = 0.48) by treatment; however, total number of cells proliferating within the jejunum was increased in steers fed high-Se wheat. Data indicate that the lower jejunal vascularity in the diet high in Se (provided from wheat) may have resulted in increased jejunal mass to meet physiological nutrient demand. Therefore, negative effects of Se level used in this study on productive performance of feedlot steers are not expected. 相似文献
995.
OBJECTIVE: To evaluate the suitability of a 'mini parallel Lack' (MPL) breathing system for use in spontaneously breathing cats and to compare the fresh gas flow requirement with that of a modified Ayre's T-piece (MATP). ANIMALS: Twenty client-owned cats, ASA I and II, presented for elective procedures requiring anaesthesia. MATERIALS AND METHODS: Pre-anaesthetic medication and induction of anaesthesia were carried out using several techniques commonly used in our teaching hospital. Anaesthesia was maintained with halothane or isoflurane vaporized in either oxygen or with a mixture of oxygen and nitrous oxide. Both breathing systems were evaluated in each cat, with the order of use randomized. Initial fresh gas flows were 300 mL kg(-1) minute(-1) for the MPL and 500 mL kg(- 1) minute(-1) for the MATP. After a 20-minute stabilization period, fresh gas flow was reduced by 200 mL minute(-1) every 5 minutes until re-breathing--defined as an increase in the inspired partial pressure of carbon dioxide to 0.3 kPa (2 mm Hg)--was detected. The fresh gas flow was then increased in 100 mL minute(-1) increments until re-breathing was no longer detectable, and this value was recorded as the minimum fresh gas flow requirement for the breathing system in use. The procedure was then repeated for the second breathing system. Minimum fresh gas flow requirements were compared using a paired Students t-test. Cardiopulmonary variables were compared using anova. Valve opening pressure was measured in the MPL using a manometer. RESULTS: The mean (+/-SD) fresh gas flow that prevented re-breathing with the MPL (510 +/- 170 mL minute(-1); equivalent to 142 +/- 47 mL kg(-1) minute(-1)) was significantly lower than that required for the MATP (1430 +/- 560 mL minute(-1); equivalent to 397 +/-155 mL kg(-1) minute(-1)). There were no significant differences in cardiopulmonary variables attributable to the use of the two breathing systems. The MPL valve opening pressure was 1.1 cm H2O. CONCLUSIONS: The MPL breathing system used lower gas flows than the MATP without affecting cardiovascular or respiratory function. Clinical relevance In spontaneously breathing cats, the MPL offers the advantages of a reduction in cost and atmospheric pollution because less volatile agent is vaporized. 相似文献
996.
997.
1. Pelleted diets, incorporating whole or ground wheat or barley in the pellets, were fed to broiler chickens and the performance, gastrointestinal development and digesta characteristics of those chickens recorded. 2. Body weight was similar with whole grain incorporation or enzyme application. Food conversion efficiency was improved by addition of enzyme to a full wheat diet. 3. Whole grain inclusion in pellets reduced proventriculus proportional mass and increased gizzard proportional mass with no apparent effects of exogenous feed enzyme addition. 4. Relative ileal mass was reduced by enzyme inclusion in a wheat diet and by inclusion of whole barley in the pellets. 5. Digesta viscosity was increased by whole wheat inclusion but reduced by enzyme inclusion irrespective of grain processing. Inclusion of 200 g/kg of barley did not alter viscosity of digesta beyond the duodenum. 6. Fresh excreta pH was higher with both cereals in the grower phase when whole grain was fed. On the barley diet, this was affected by enzyme addition, which created higher pH from a point earlier in the grower phase than when no enzyme was employed. 7. Evidence of a complex interaction between higher viscosity and pH being involved in differences in ileal relative mass was found through significant relationships being produced by enzyme use on the wheat diet alone. 相似文献
998.
Drew ML Johnson L Pugh D Navarre CB Taylor IT Craigmill AL 《Journal of veterinary pharmacology and therapeutics》2004,27(1):13-20
Pharmacokinetic studies of antibiotics in South American camelids are uncommon, therefore drugs are often administered to llamas and alpacas based on dosages established in other domestic species. The disposition of ceftiofur sodium was studied in llamas following intramuscular administration and in alpacas following intravenous and intramuscular administration. Eleven adult llamas were given ceftiofur sodium by intramuscular injection. Each animal received either a standard dose of 2.2 mg/kg or an allometrically scaled dose ranging from 2.62 to 2.99 mg/kg in a crossover design. Ten adult alpacas were given ceftiofur sodium by intravenous and intramuscular injections. Each animal received a standard dosage of 1 mg/kg or an allometrically scaled dose ranging from 1.27 to 1.44 mg/kg i.v., and 1.31-1.51 mg/kg i.m. Blood samples were collected at 0, 0.25, 0.5, 1, 2, 4, 8, 12, 24, 36, 48, and 72 h after administration of the ceftiofur. Pharmacokinetic parameters of ceftiofur in llamas and alpacas were similar following i.m. dosing at both dose levels. The only differences noted were in the total AUC between dose levels, but the AUC/dose values were not different. A sequence effect was noted in the alpaca data, which resulted in lower AUCs for the second dose when the i.v. dose was given first, and with higher AUCs for the second dose when the i.m. dose was given first. Overall, ceftiofur pharmacokinetics in llamas and alpacas are similar, and also very similar to reported parameters for sheep and goats. 相似文献
999.
G N Taylor L Shabestari W Angus R D Lloyd C W Mays 《American journal of veterinary research》1979,40(9):1316-1318
The age-specific frequency of 11 primary pulmonic neoplasms in a closed Beagle colony is presented. The first tumor occurred at 5 years, and the frequency increased progressively in the older age classes. All of the tumors arose from sites distal to the principal bronchi. Although metastases appeared to occur relatively late, with respect to course of tumor development, they were noted in approximately a half of the dogs and most frequently involved the bronchial lymph nodes. 相似文献
1000.
On the basis of plasma concentrations of pantothen[14C]ate, after its intravenous administration, a three compartment open model was proposed to predict the pharmacokinetics of pantothenate in dogs. The model assumed a central compartment comprising the plasma and other extracellular fluids, and distribution into two other peripheral compartments, one of which included the liver. Elimination of unchanged pantothenate was assumed to occur by metabolism from the compartment which included the liver. Distribution of pantothen[14C]ate from the plasma compartment into the liver compartment was shown to be very rapid; during 10 min after intravenous administration about 80 per cent of the dose had been cleared from the plasma compartment. The model successfully predicted the influence (first pass effect) of the liver on the fraction of an oral dose which reached the peripheral plasma unchanged. 相似文献