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701.
E M Hardie R L Page P L Williams W D Fischer 《American journal of veterinary research》1991,52(11):1821-1825
Cisplatin (90 mg/m2) was administered in a 5-minute bolus IV infusion to dogs at 8 AM (n = 6) or 4 PM (n = 6). Blood and urine samples were collected over a 4-hour period for statistical moment pharmacokinetic analysis. Mean urinary excretion rate of total platinum was increased, whereas mean plasma residence time of ultrafilterable platinum was decreased, in the group treated at 4 PM (PM group), compared with those treated at 8 AM (AM group). Over a 2-week postinfusion-monitoring period, both groups of dogs developed decreases in creatinine clearance, urine/serum osmolality ratio (UOsm/SOsm), specific gravity, and increase in BUN, serum creatinine concentration, urine gamma-glutamyltranspeptidase/urine creatinine ratio (UGGT/UCr), fractional excretion of magnesium, and fractional excretion of phosphate. Urine specific gravity and UOsm/SOsm were significantly decreased, whereas UGGT/UCr and BUN were significantly increased in the AM group, compared with the PM group. The time of administration had a significant effect on the pharmacokinetics of cisplatin, which resulted in significant differences in cisplatin-induced renal toxicosis. 相似文献
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703.
Retinopathy in anemic cats 总被引:1,自引:0,他引:1
C A Fischer 《Journal of the American Veterinary Medical Association》1970,156(10):1415-1427
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The blood pressure of pigs for slaughter were measured. Onset of electric anaesthesia was followed by blood pressure rise of about 25 per cent. Peak values of 100 per cent in excess of the original pressure were recorded in some cases. Termination of the electric stimulus, generally, was followed by sudden blood pressure drop. The original pressure usually was reached ten seconds from the debleeding puncture. With continued debleeding, it stayed at 75 mm Hg after 50 seconds on average. Extraordinary high rise in blood pressure in response to electric stimulation usually was followed by rapid pressure drop, whereas in cases with moderate rise at the time of anaesthesia the subsequent decline was at slower rates. 相似文献
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F. Poliakoff M. Fischer‐Le Saux G. Hunault C. Franois C. Rivoal S. Bonneau S. Perret H. Soubelet D. Caffier 《EPPO Bulletin》2005,35(1):61-68
CABIQ is a specific computer‐assisted identification system for the reliable and rapid identification of the main regulated phytopathogenic bacteria. It is based on phenotypic and genomic properties of bacteria. About 500 reference strains have been used to initiate the database, including conventional phenotypic tests and the Biotype 100 (BioMérieux) galleries. The CABIQ system, with its database and reference matrices, is a guide on the tests to be done when identifying new isolates. The modules dealing with phenotypic and Biotype100 characteristics are already finalized. Results on repetitive PCR will soon be added to the system. This opens interesting perspectives for improving the reliability of computer‐assisted identification. 相似文献