Hepatic drug metabolism in rats: impairment in a dirty environment   总被引：1，自引：0，他引：1  

E S Vesell  C M Lang  W J White  G T Passananti  S L Tripp 《Science (New York, N.Y.)》1973,179(76):896-897

Reduction of aniline hydroxylase activity, ethylmorphine N-dementhylase activity, and cytochrome P-450 content occurred in hepatic microsomes of rats kept under dirty conditions, defined as accumulation for 1 week of urine and feces in pans under the wire mesh cages. In comparison with rats that had urine and feces removed twice daily from such pans, rats kept over Kimpak bedding or over Litter Green, changed twice daily, also showed reduced drug-metabolizing activity in hepatic microsomes, but to a lesser degree than the dirty rats. Placement of a filter top on cages for 1 week also decreased drug-metabolizing activity. These experiments suggest that the relative cleanliness of an animal's environment can influence hepatic microsomal drug metabolism.  相似文献   

MATHEMATICS IN NINETEENTH CENTURY SCIENCE     

White HS 《Science (New York, N.Y.)》1916,43(1113):583-592

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FORTY YEARS' FLUCTUATIONS IN MATHEMATICAL RESEARCH     

White HS 《Science (New York, N.Y.)》1915,42(1073):105-113

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Growth of SiO2 at room temperature with the use of catalyzed sequential half-reactions     

JW Klaus  O Sneh  SM George 《Science (New York, N.Y.)》1997,278(5345):1934-1936

Films of silicon dioxide (SiO2) were deposited at room temperature by means of catalyzed binary reaction sequence chemistry. The binary reaction SiCl4 + 2H2O --> SiO2 + 4HCl was separated into SiCl4 and H2O half-reactions, and the half-reactions were then performed in an ABAB ellipsis sequence and catalyzed with pyridine. The pyridine catalyst lowered the deposition temperature from >600 to 300 kelvin and reduced the reactant flux required for complete reactions from approximately 10(9) to approximately 10(4) Langmuirs. Growth rates of approximately 2.1 angstroms per AB reaction cycle were obtained at room temperature for reactant pressures of 15 millitorr and 60-second exposure times with 200 millitorr of pyridine. This catalytic technique may be general and should facilitate the chemical vapor deposition of other oxide and nitride materials.  相似文献   

Psychological and social barriers to women in science   总被引：1，自引：0，他引：1  

M S White 《Science (New York, N.Y.)》1970,170(956):413-416

Commitment and creativity in science are not merely a function of an individual's competence or excellence, but are a product of the social environment as well. Acceptance and recognition from significant other people (one's peers and other professionals), and opportunities for stimulating and challenging interaction are essential for developing a strong occupational or professional identiy, and for creating the inner sense of role competence which can lead to greater commitment and productivity in professional work. Unfortunately women, especially those who have experienced interrupted or discontinuous careers, find such opportunities and acceptance difficult to obtain.  相似文献   

University affiliation and recognition: national academy of sciences     

Kash DE  White IL  Reuss JW  Leo J 《Science (New York, N.Y.)》1972,175(4026):1076-1084

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The White Pine Copper Deposit,Ontonagon County,Michigan     

White WS  Wright JC 《Science (New York, N.Y.)》1954,119(3089):354-355

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Middle Paleolithic assemblages from the Indian subcontinent before and after the Toba super-eruption     

Petraglia M  Korisettar R  Boivin N  Clarkson C  Ditchfield P  Jones S  Koshy J  Lahr MM  Oppenheimer C  Pyle D  Roberts R  Schwenninger JL  Arnold L  White K 《Science (New York, N.Y.)》2007,317(5834):114-116

The Youngest Toba Tuff (YTT) eruption, which occurred in Indonesia 74,000 years ago, is one of Earth's largest known volcanic events. The effect of the YTT eruption on existing populations of humans, and accordingly on the course of human evolution, is debated. Here we associate the YTT with archaeological assemblages at Jwalapuram, in the Jurreru River valley of southern India. Broad continuity of Middle Paleolithic technology across the YTT event suggests that hominins persisted regionally across this major eruptive event.  相似文献   

Long-Term Variable Rate Lime and Phosphorus Application for Piedmont No-Till Field Crops     

Weisz  Randy  Heiniger  Ron  White  Jeffrey G.  Knox  Ben  Reed  Lonnie 《Precision Agriculture》2003,4(3):311-330

Variable rate (VR) fertilizer application is a paradigm with potential to improve input efficiency and farm profitability. It is widely marketed by commercial applicators in the southeastern US. However, field studies comparing VR with traditional management have not demonstrated consistent, positive results. The objectives of this study were: (1) to determine the soil impact, crop response and economic potential of VR phosphorus (P) and lime application in a North Carolina Piedmont no-till field crop system using intensive soybean [Glycine max (L.) Merr.] production and (2) to economically evaluate alternatives to standard commercial grid soil sampling for directing VR P and lime. A 23-ha long-term no-till field in the SE Piedmont was divided into 0.4ha plots assigned to either VR or uniform P and lime application. Grid soil sampling and VR P and lime application were done prior to four crops over 3 years: full season soybean, wheat (Triticum aestivum L.)–double cropped soybean, and full season soybean. Soil test P, pH and crop yield response to VR P were inconsistent. Soil pH in areas with low pH initially did increase in response to VR lime, but it took two to three applications to bring all of these areas to the target pH. Once VR-liming raised initially low soil pH to levels close to target, yield of soybean, but not wheat, were up to 0.74Mgha^–1 higher than with uniform lime. Even with significantly higher soybean yields associated with VR lime, 3 years of grid sampling and VR application were not profitable compared to uniform application. The results indicated that VR lime could be profitable if the initial grid sampling data were used either for 2 consecutive years, or if it was used to restrict future grid sampling to specific areas requiring further VR lime.  相似文献   

A gene expression map for the euchromatic genome of Drosophila melanogaster     

Stolc V  Gauhar Z  Mason C  Halasz G  van Batenburg MF  Rifkin SA  Hua S  Herreman T  Tongprasit W  Barbano PE  Bussemaker HJ  White KP 《Science (New York, N.Y.)》2004,306(5696):655-660

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