Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L.     

Sanjay M. Jachak  Raju GautamC. Selvam  Himanshu MadhanAmit Srivastava  Taj Khan 《Fitoterapia》2011,82(2):173-177

The standardized EtOAc, MeOH and 70% EtOH extracts of Tridax procumbens aerial parts showed significant inhibition of rat paw edema at a medium dose of 200 mg/kg and the EtOAC extract was the most active. These extracts were standardized by HPLC with the help of chemical markers. Further, the extracts were evaluated for COX-1 and COX-2 inhibitory activity and EtOAc extract exhibited the highest inhibition of COX-1 and COX-2 at 50 μg/mL. Cent aurein, centaureidin and bergenin were isolated as COX-1 and COX-2 inhibitory principles from the EtOAc extract. The extracts also exhibited antioxidant activity against DPPH and ABTS free radicals. The anti-inflammatory activity of T. procumbens aerial parts could be at least in part due to COX-1, COX-2 enzyme inhibition and free radical-scavenging activities which may be attributed to the presence of flavonoids and other polyphenols in the extracts.  相似文献   

Cefotaxime pharmacokinetics in Arabian camel (Camelus dromedarius) calves after single intravenous injection     

Altayban  Abdullah  Kandeel  Mahmoud  Tahoun  Amin  Al-Nazawi  Mohammed 《Tropical animal health and production》2020,52(2):887-891

Tropical Animal Health and Production - Cefotaxime is a third-generation broad-spectrum cephalosporin acting on a wide range of Gram-positive and Gram-negative bacteria. In this work, the...  相似文献   

Effect of increasing pre-pubertal concentrate levels on reproductive and lactation performance of Nili-Ravi Buffalo heifers     

Saadullah  Muhammad  Iqbal  Zeeshan Muhammad  Naveed-ul-Haque  Muhammad  Hifzulrahman  Bhatti  Jalees Ahmed  Abdullah  Muhammad 《Tropical animal health and production》2020,52(6):2897-2903

The objective of this study was to determine the effect of increasing total nutrient supply by increasing level of concentrate supplementation in forage-based diet of growing Nili-Ravi buffalo replacement heifers on pre-pubertal growth rate and its impact on age at puberty and post-pubertal productive and reproductive performance. Twenty-eight Nili-Ravi buffalo heifers of 7 ± 1 month age were divided into 3 groups. The treatments were 3 levels of concentrate (crude protein (CP) = 17.9%, metabolisable energy (ME) = 2.66 Mcal/kg), i.e. 0.5, 1, and 1.5% of the body weight referred as low, medium, and high treatments, respectively. Irrespective of pre-pubertal treatment, all the heifers received similar feed after puberty up to completion of their first lactation. The results of the study showed a similar response across the treatments in age, weight, and condition at puberty, weight at calving, lactation length, and yield. The medium and high treatments resulted in poor reproductive performance because of higher services per conception and less number of heifers confirmed conceived compared with low treatment. The low treatment resulted in less mortality compared with medium and high treatments. The feeding cost per animal at puberty, conception, and calving was lowest for treatment low as compared with medium and high. In conclusion, the results of the study showed that Nili-Ravi buffalo heifers achieved puberty at 23 months with feeding of concentrate (CP = 17.9%, ME = 2.66 Mcal/kg) during pre-pubertal stage at the rate of 0.5% of the body weight with better reproductive performance.

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Spirulina inclusion levels in a broiler ration: evaluation of growth performance,gut integrity,and immunity     

Khan  Sarzamin  Mobashar  Muhammad  Mahsood  Farid Khan  Javaid  Shahbaz  Abdel-Wareth  A. A.  Ammanullah  Haq  Mahmood  Asif 《Tropical animal health and production》2020,52(6):3233-3240

Tropical Animal Health and Production - Spirulina has been used as a food source from many years for human and animals because of its superior profile of nutrition. Spirulina (SPA) having antiviral...  相似文献   

Tasco(®), a product of Ascophyllum nodosum, imparts thermal stress tolerance in Caenorhabditis elegans     

Kandasamy S  Fan D  Sangha JS  Khan W  Evans F  Critchley AT  Prithiviraj B 《Marine drugs》2011,9(11):2256-2282

Tasco^®, a commercial product manufactured from the brown alga Ascophyllum nodosum, has been shown to impart thermal stress tolerance in animals. We investigated the physiological, biochemical and molecular bases of this induced thermal stress tolerance using the invertebrate animal model, Caenorhabiditis elegans. Tasco^® water extract (TWE) at 300 μg/mL significantly enhanced thermal stress tolerance as well as extended the life span of C. elegans. The mean survival rate of the model animals under thermal stress (35 °C) treated with 300 μg/mL and 600 μg/mL TWE, respectively, was 68% and 71% higher than the control animals. However, the TWE treatments did not affect the nematode body length, fertility or the cellular localization of daf-16. On the contrary, TWE under thermal stress significantly increased the pharyngeal pumping rate in treated animals compared to the control. Treatment with TWE also showed differential protein expression profiles over control following 2D gel-electrophoresis analysis. Furthermore, TWE significantly altered the expression of at least 40 proteins under thermal stress; among these proteins 34 were up-regulated while six were down-regulated. Mass spectroscopy analysis of the proteins altered by TWE treatment revealed that these proteins were related to heat stress tolerance, energy metabolism and a muscle structure related protein. Among them heat shock proteins, superoxide dismutase, glutathione peroxidase, aldehyde dehydrogenase, saposin-like proteins 20, myosin regulatory light chain 1, cytochrome c oxidase RAS-like, GTP-binding protein RHO A, OS were significantly up-regulated, while eukaryotic translation initiation factor 5A-1 OS, 60S ribosomal protein L18 OS, peroxiredoxin protein 2 were down regulated by TWE treatment. These results were further validated by gene expression and reporter gene expression analyses. Overall results indicate that the water soluble components of Tasco^® imparted thermal stress tolerance in the C. elegans by altering stress related biochemical pathways.  相似文献   

Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources     

Hesham Fahmy  Jordan K. Zjawiony  Takao Konoshima  Harukuni Tokuda  Shabana Khan  Sherief Khalifa 《Marine drugs》2006,4(2):28-36

In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well as the multiplicity of skin tumors per mouse compared to untreated controls.  相似文献   

Preparation and nutritional quality of high protein food extracts from immature corn,whole soybean and dry whole milk     

Nurul H. Khan  Ricardo Bressani 《Plant foods for human nutrition (Dordrecht, Netherlands)》1987,37(2):141-149

Five foods have been prepared from water extracts of immature corn (IC), immature corn-milk (CM) and immature corn-whole soybean (CS). The method of preparation followed either the common practice used for the immature corn drink or with certain modifications to increase yield. The protein quality of the three foods (IC, CM and CS) were evaluated and compared with that of casein. They had same digestibility (87–88%) but differed in protein quality. Two other foods, CS-1 and CS-2 were prepared using mechanical pressing of solubles. The corn-soy foods, CS-1 and CS-2, had almost the same digestibility as that of casein. An analysis of costs of materials indicated that the production of corn-soy food will be cheaper than the corn-milk food.  相似文献   

Unraveling Wheat Grain Quality,Physiological Indices,Dry Matter Accumulation,and Attenuating Water Stress Adverse Effect Via Foliar Potassium Application at Different Growth Stages     

Ali  Nawab  Anjum  Muhammad Mehran  Khan  Gul Roz  Ali  Rovaid 《Gesunde Pflanzen》2022,74(1):41-52

Water resources are increasingly scarce, and in drought prone production systems, the capability of the plant to recover its adverse effects is important for yield stability. There is an urgent need to develop water-saving strategies for wheat production. Water stress at critical growth stages diminishes wheat production and has harmful effects on crop growth and development; however, regulated water deficit and potassium foliar application ameliorates its adverse effect up to a certain extent. Consequently, the water deficit effect at different growth stages of the crop with exogenous application of potassium was evaluated in a screenhouse experiment in a complete randomized design (CRD) having four repeats. Varieties of wheat, i.e. Lalma (drought resistant) and Pakhtunkhwa-2015 (drought susceptible), were sown. Water deficit, i.e. mild water stress (50% of water required for field capacity) and severe stress (no application of water), at different growth stages of the crop were imposed. Potassium (K) foliar spray (1%) from potassium sulfate (K₂SO₄) was applied at the respective stage subjected to water deficit levels. Internal water status, i.e. relative water content (RWC) and water retention capacity (WRC), were attained maximum at tillering stage under mild stress than the rest of the stages with maximum for Lalma. Conversely, water saturation deficit (WSD) and water uptake capacity (WUC) were higher under severe stress imposed at grain filling stage. Theses indices were maintained by foliar potassium application. Similarly, dry matter (DM) allocation varied for stress level imposition and translocation to other parts were improved under foliar K application. The chlorophyll indices, i.e., soil plant analysis development (SPAD) value, also decreased with the severity of water deficit. Grain yield was higher under stress imposition at grain filling stage than the rest of the stages, though severe water stress decreased yield significantly. The Potassium (K) foliar spray showed no prominent effect at grain filling. Canopy temperature increased with stress severity and was maintained under K foliar spray. Osmotic adjustment, water and turgor potential were affected by water stress and maintained with foliar K spray. Grain quality and biochemical traits of wheat were affected severely under water deficit. Potassium foliar spray was found to decrease the adverse effect of the water stress and hence maintained the quality and biochemical characters. It is concluded that application of foliar potassium decreases the adverse effects of water stress at any growth stage, minimises the stress indices drastic effect and maintains the internal water balance of the crop at different stages subjected to water deficit.

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Impact of Irrigation Timing and Weed Management Practices on Chlorophyll Content and Morphological Traits of Tomato (Solanum lycopersicum Mill.)     

Fawad  Muhammad  Khan  Muhammad Azim 《Gesunde Pflanzen》2022,74(2):317-332

Weeds are a major biotic constraint; compete with crop for the same resources and ultimately reduce productivity. This study evaluated the impact of irrigation intervals and weed management treatments on chlorophyll content and morphological growth of tomato to find an appropriate integrated weed management strategy. Two-year field experiments (2018/2019) were conducted at district Mardan (34°15′38″ N and 72°6′36″ E). Tomato F1 hybrid (Taj?3592) was transplanted during March. The experiments were laid out in a randomized complete-block design in split-plot arrangement with three replications. The main block comprised three irrigation intervals (3, 6, and 9 days) and the sub-block included weed management treatments: transparent polythene, black polythene, weeding except Orobanche, sole weeding of Orobanche, weeding of all weeds, copper oxychloride 1.5?kg a.i ha^?1 (single dose), copper oxychloride 1.5?kg a.i ha^?1 (split doses), copper oxychloride?+?humic acid 25?kg ha^?1 (single dose), copper oxychloride?+?humic acid 25?kg ha^?1 (split doses), copper sulphate 2?kg ha^?1 (single dose), copper sulphate 2?kg ha^?1 (split doses), ammonium sulphate 200?kg ha^?1 (single dose), ammonium sulphate 200?kg ha^?1 (split doses), pendimethalin 33 EC 1.44?kg a.i ha^?1, glyphosate 48 SL 1.5?kg a.i ha^?1, and weedy check. Lowest relative weed density (RWD) of O. cernua (2.23%) and highest RWD of O. cernua (38.01%) were recorded in the 3? and 9?day irrigation intervals, respectively. However, 3?day irrigation interval resulted in highest fresh weed biomass (5794?kg ha^?1). Moreover, the 6?day irrigation interval significantly increased chlorophyll content by 11 and 5%, leaf area by 23 and 6%, and number of branches plant^?1 by 30 and 22% compared to 9? and 3?day irrigation intervals, respectively. Among the weed management treatments, black polythene resulted in the highest weed control efficiency (96%), increasing chlorophyll content by 16%, leaf area by 33%, and number of branches plant^?1 by 64% vs. weedy check. Consequently, 6?day irrigation intervals?×?black polythene could be the best weed management strategy, followed by transparent polythene, weeding of all weeds, pendimethalin, glyphosate, and ammonium sulphate.

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Zinc and Boron Application at Different Phenological Stages Alleviates Tree Growth,Fruit Yield and Quality of Sweet Orange Cv. ‘Blood Red’     

Walli  Sammen  Hafiz  Ishfaq Ahmed  Khan  Rashid Iqbal  Bashir  Muhammad Ajmal  Uddin  Sareer  Khan  Shakir Ullah  Ajmal  Usman  Hussain  Sajjad  Khalid  Muhammad Fasih 《Gesunde Pflanzen》2022,74(2):385-396

The deficiency of micronutrients, particularly zinc (Zn) and boron (B) has affected vegetative growth, yield and fruit quality of sweet orange in many citrus growing areas of Pakistan. The present study was conducted in 2015 and 2016 to determine the impact of Zn and B supplementation on growth and quality of sweet orange cv. ‘Blood red’. Pre-harvest foliar application of variant Zn and B levels was done at different phenological stages of fruit growth and development, i.e., full bloom, fruit set and premature stage. Results have concluded that pre-harvest foliar application of Zn and B augmented phosphorous, Zn, B, potassium, iron, and manganese contents in leaves, particularly Zn and B content from deficient to optimal level. Moreover, the combined application of Zn and B has also significantly enhanced vegetative characters such as tree height and spread along with reproductive characters, i.e., incremented numbers of fruit, fruit weight, total soluble solids, titratable acidity and ascorbic acid contents. However, among stage comparison, outcomes depicted that foliar application of Zn and B at full bloom?+?fruit set?+?premature stage resulted in maximum production with high quality fruits.

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