Preliminary report of postoperative complications of phacoemulsification in Pugs: A multicenter retrospective study of 32 cases     

Christine Boss  Noelle La Croix  Phillip A. Moore  David A. Wilkie  Federica Maggio  Kenneth Tomo Wiggans  David J. Maggs  Kevin Kaiser  John S. Sapienza  Kay Kim  Rachel Strauss  Alexandra van der Woerdt  Gretchen Schmidt 《Veterinary ophthalmology》2020,23(3):442-449

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Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment     

Laura Marconato  Mathias Weyland  Nina Tresch  Federica Rossi  Vito Leone  Carla Rohrer Bley 《Veterinary and comparative oncology》2020,18(3):362-369

Recently, a multimodal approach to oral squamous cell carcinoma (SCC) in cats, combining medical treatment and accelerated radiation therapy, showed a substantial outcome improvement in a small pilot study. Herein we retrospectively review 51 cats with unresectable, histologically confirmed oral SCC and a complete initial staging work‐up: cats in group A (n = 24) received medical anti‐angiogenic treatment consisting of bleomycin, piroxicam and thalidomide, cats in group B (n = 27) received the anti‐angiogenic treatment and concurrent accelerated hypofractionated radiation therapy with 48Gy delivered in 10 fractions. Overall median progression‐free interval (PFI) was poor with 70 days (95% CI: 48;93). In the irradiated cats (group B), however, PFI was significantly longer with 179 days (95% CI: 58;301) days, vs 30 days (95% CI: 23;38) in medically only treated cats (P < .001). Overall median overall survival (OS) was 89 days (95% CI: 55;124), again significantly longer in the irradiated cats (group B) with 136 (95% CI: 40;233) vs 38 days (95% CI: 23;54) (P < .001). In 8 of the 27 (29.6%) cats in group B, however, severe toxicity (grade 3) occurred. Neither onset nor severity of toxicity could be associated with any of the tested variables, including anatomic site, tumour size, clinical stage and duration of neoadjuvant medical treatment. Given the potential severe acute effects and the impact on quality of life after chemo‐radiotherapy, owners must be clearly informed about the risks of treatment. With the overall poor outcome and high occurrence of acute toxicity, we cannot recommend the use of this accelerated radiation protocol combined with anti‐angiogenic therapy for oral SCC in cats.  相似文献   

Comparison of four peribulbar anaesthetic techniques: a preliminary study in equine cadavers     

Vanessa Rabbogliatti  Donatella De Zani  Davide D. Zani  Federica Di Cesare  Federica A. Brioschi  Daniela Gioeni  Benedetta Crivellari  Giuliano Ravasio 《Veterinary anaesthesia and analgesia》2021,48(3):442-450

ObjectiveTo compare the peribulbar injectate distribution and probability of regional anaesthesia of four peribulbar anaesthetic techniques in equine cadavers.Study designProspective experimental cadaver study.AnimalsA total of 12 isolated equine cadaver heads and 24 eyes.MethodsThe 24 orbits underwent one of four injection techniques (six orbits each) with a mixture (1:4) of contrast medium and saline (CM): 20 mL ventrolateral peribulbar injection (V-20), 20 mL dorsolateral peribulbar injection (D-20), combined ventrolateral and dorsolateral peribulbar injections 10 mL each (VD-20) or 20 mL each (VD-40). To evaluate and score CM distribution at the base of, within the extraocular muscle cone (EOMC), and around the optic nerve (before and after pressure application to the periorbital area), computed tomography was performed. To assess the probability of achieving locoregional anaesthesia, two criteria were applied and both scored as ‘likely’, ‘possible’ or ‘unlikely’. To compare CM distribution scores between injection techniques, Kruskal-Wallis analysis of variance was used. Mann-Whitney U test was used for post hoc comparisons between groups when needed. A p value < 0.05 was considered significant.ResultsThe CM distribution within the EOMC and around the optic nerve circumference was detected as ‘possible’ only after pressure application in seven out of 24 orbits (V-20, 3; D-20, 1; VD-40, 3). It was never considered ‘likely’ either before or after pressure application. The CM distribution at the EOMC base was considered ‘likely’ to provide regional anaesthesia in 50% (V-20), 0% (D-20), 33% (VD-20), 100% (VD-40) and in 66% (V-20), 16% (D-20), 50% (VD-20), 100% (VD-40) before and after applying pressure, respectively.Conclusions and clinical relevanceComplete regional anaesthesia seems more likely using the VD-40 technique, although the authors advise caution due to the risk of potential complications. Future studies are necessary to evaluate the efficacy of the technique in vivo.  相似文献   

Effects of Genotype and Environment on Phenolic Acids Content and Total Antioxidant Capacity in Durum Wheat     

Daniela Martini  Federica Taddei  Isabella Nicoletti  Roberto Ciccoritti  Danilo Corradini  Maria Grazia D'Egidio 《Cereal Chemistry》2014,91(4):310-317

In cereals, phenolic acid (PA) content and total antioxidant capacity (TAC) may have a wide range of variability, probably because of several factors influencing the occurrence of grain antioxidants, which include genotype, environment, and their possible interactions. However, only a few studies have investigated the influence of these factors on durum wheat. In the present study, we investigated the impact of the genetic and environmental factors on the profile and content of PAs occurring as soluble free, soluble conjugated, and insoluble bound compounds, as well as on the TAC level, in three genotypes of durum wheat grown in three different Italian agroclimatic areas during two crop years. The results show that genotype, environment, and crop year have highly significant effects on TAC levels and on PA contents. In particular, TAC and free PAs are most influenced by year, whereas conjugated and bound PAs are most influenced by environment × year and genotype, respectively. Therefore, it is evidenced that genetic and environmental factors affect the antioxidant activity and the content of the three forms of PAs in durum wheat to different extents.  相似文献   

Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming     

Benvenuti F  Hugues S  Walmsley M  Ruf S  Fetler L  Popoff M  Tybulewicz VL  Amigorena S 《Science (New York, N.Y.)》2004,305(5687):1150-1153

Upon maturation, dendritic cells (DCs) acquire the unique ability to activate na?ve T cells. We used time-lapse video microscopy and two-photon imaging of intact lymph nodes to show that after establishing initial contact between their dendrites and na?ve T lymphocytes, mature DCs migrate toward the contacted lymphocytes. Subsequently, the DCs tightly entrap the T cells within a complex net of membrane extensions. The Rho family guanosine triphosphatases Rac1 and Rac2 but not Rho itself control the formation of dendrites in mature DCs, their polarized short-range migration toward T cells, and T cell priming.  相似文献   

A study of the prevalence and genotypes of Giardia duodenalis infecting kennelled dogs     

Scaramozzino P  Di Cave D  Berrilli F  D'Orazi C  Spaziani A  Mazzanti S  Scholl F  De Liberato C 《Veterinary journal (London, England : 1997)》2009,182(2):231-234

Giardia duodenalis is a protozoan parasite of animals that is zoonotic. Given the capacity of this organism to spread via the faecal–oral route, animals held in overcrowded and unhygienic conditions are at high risk of infection. Faecal samples from dogs in three kennels in Rome were examined by microscopy and PCR for G. duodenalis, and the prevalence data generated were correlated with variables such as kennel identity, age of dog, length of time the dog had been kennelled and clinical signs.The overall prevalence of the parasite in the faecal samples was 20.5% and was higher in samples from the largest kennel, which had the greatest turnover of dogs, and in faecal samples from younger animals. Giardia cysts were found more frequently in diarrhoeic animals but were also found in dogs with no clinical signs. Although the finding that the majority of isolates were dog-specific rather than zoonotic genotypes suggests that the zoonotic risk from this pathogen is less than previously thought, the higher prevalence of infection in younger dogs may pose a specific public health issue as such animals are more frequently re-homed with families.  相似文献   

Peripheral neuropathy in a cat with renal lymphoma     

Paola Cavana  Federica Sammartano  Maria T. Capucchio  Deborah Catalano  Alberto Valazza  Anna M. Farca 《Journal of Feline Medicine and Surgery》2009,11(10):869-872

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Quantitative methods for defining percentage area targets for habitat types in conservation planning     

Carlo Rondinini  Federica Chiozza 《Biological conservation》2010,143(7):1646-2597

The Earth’s resources are finite, therefore planning for their use requires the definition of broad goals and the formulation of operational targets derived from goals, that enable decisions to be made and success measured. The objective of this study was to review methods for the formulation of percentage conservation targets for the coverage of habitat types within a network of conservation areas. We reviewed the scope and data requirements of these methods and discussed the strengths and limitations of their application. We identified five groups of methods applicable to habitat types that define: (1) fixed percentage targets across all habitats based on species-area relationship, or habitat-specific targets based on (2) species-area relationship, (3) heuristic principles, (4) trade-off of target size with reserved area, or (5) spatially-explicit Population Viability Analysis (PVA) for selected species. No ideal method exists and two factors should guide the choice of a method: the type of biodiversity goal and data availability. Given the lack of perfect biodiversity data, we suggest the use of a composite target based on a combination of methods.  相似文献   

NODULAR FAT NECROSIS IN THE FELINE AND CANINE ABDOMEN     

Tobias  Schwarz  MA  Dr. Med. Vet.  Federica  Morandi  DVM  Giacomo  Gnudi  Dr. Med. Vet.  Erik  Wisner  DVM  Calum  Paterson  MSc  Martin  Sullivan  BVMS  PhD  Pamela  Johnston  BVM&S  PhD 《Veterinary radiology & ultrasound》2000,41(4):335-339

The radiographic appearance of nodular fat necrosis is described in ten cats and one dog. The most common radiographic sign was the presence of a focal mineralized circular to oval soft tissue mass in the abdominal fat as present in 9 cats. These masses had a distinct eggshell-like rim encapsulating the lesion. In one cat and one dog multiple masses were present, without radiographic signs of mineralization. Abdominal ultrasound was performed in three cats and one dog, findings included the presence of hyperechoic masses with associated acoustic shadowing, some with a hypoechoic centre. Almost all animals were old and obese. In three cats and one dog, changes were confirmed with biopsy or post mortem examination. Lesions having the appearance of those in this paper are most likely incidental findings and should not be confused with abdominal masses of neoplastic origin. Ultrasound can be helpful in identifying such lesions.  相似文献