Clinical utility of urine kidney injury molecule-1 (KIM-1) and gamma-glutamyl transferase (GGT) in the diagnosis of canine acute kidney injury     

Ilaria Lippi  F. Perondi  V. Meucci  B. Bruno  V. Gazzano  G. Guidi 《Veterinary research communications》2018,42(2):95-100

The aim of the present study was to evaluate the sensitivity and specificity of urine KIM-1 and urine GGT for the detection of naturally-occurring AKI, compared to healthy control dogs, dogs with stable chronic kidney disease (CKD), and dogs with lower urinary tract disorders (LUTD). The study included AKI grade 1 (n?=?21), AKI grade 2 to 5 (n?=?11), stable CKD (n?=?11), LUTD (n?=?15), and healthy dogs (n?=?37). Urine KIM-1 (ng/mg) and GGT (U/l) were normalized to urine creatinine (uCr). Statistically significant difference in KIM/uCr (p?=?0.0007) and GGT/uCr (p?<?0.0001) was found among the study groups. Area under the curve (AUC) for KIM-1/uCr and GGT/uCr as predictors of AKI was 0.81 and 0.91 respectively. Values of KIM-1/uCr of 0.73 ng/mg and of GGT/uCr of 54.33 showed the best combination of sensitivity and specificity (75% and 75.6%; 85.7% and 89.1% respectively). A significant positive correlation (p?<?0.0001) between KIM-1/uCr and GGT/uCr was found. Both urine KIM-1/uCr and GGT/uCr seemed to be potentially good markers for the diagnosis of AKI. Dogs with AKI showed significantly higher levels of urine KIM-1/uCr and urine GGT/uCr, compared with healthy dogs. Caution should be used in the evaluation of elevated urine KIM-1/uCr and GGT/uCr in dogs with pre-existing CKD and/or LUTD. Urine KIM-1/uCr and GGT/uCr might have a significant clinical utility, as complementary test, particularly in diagnosis early, non-azotemic stages of AKI.  相似文献   

Feline herpesvirus ulcerative dermatitis: an atypical case?          下载免费PDF全文

Ilaria Porcellato  Luca Luciani  Maria Luisa Marenzoni  Sara Francesca Santagostino  Monica Sforna  Luca Mechelli  Chiara Brachelente 《Veterinary dermatology》2018,29(3):258-e96

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Prognostic value of mitral annular systolic plane excursion and tricuspid annular plane systolic excursion in cats with hypertrophic cardiomyopathy     

Ilaria Spalla  Jessie Rosie Payne  Kieran Borgeat  Virginia Luis Fuentes  David John Connolly 《Journal of Veterinary Cardiology》2018,20(3):154-164

Introduction

Hypertrophic cardiomyopathy (HCM) has a variable prognosis; left atrial size, presence of clinical signs and left ventricular systolic function have been shown to predict outcomes. Mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE) assess longitudinal ventricular systolic function and are decreased in cats with HCM. The aim of the study was to ascertain whether MAPSE and TAPSE have prognostic value in HCM and if cats with pleural effusion have lower MAPSE and TAPSE than cats with pulmonary oedema.

Animals

One hundred eighty-four client-owned cats diagnosed with HCM.

Methods

This is a retrospective study. Echocardiography was used to diagnose HCM (end-diastolic left ventricular wall thickness ≥ 6 mm) and to measure MAPSE and TAPSE. Survival information was obtained.

Results

No multivariable model including MAPSE or TAPSE could be generated in this population. Cats with pleural effusion ± pulmonary oedema had lower MAPSE measured at the interventricular septum (MAPSE IVS) and TAPSE, compared with cats with pulmonary oedema only. MAPSE IVS was the only factor predicting pleural effusion on multivariable regression model.

Conclusions

Lower MAPSE and TAPSE were not independently associated with outcomes on multivariable analysis. Cats with pleural effusion ± pulmonary oedema had lower TAPSE and MAPSE IVS than cats with pulmonary oedema, and MAPSE IVS was the only predictive factor associated with the development of pleural effusion in this population.  相似文献   

Multiple dermoid sinuses of type Vb and IIIb on the head of a Saint Bernard dog     

Anna Perazzi  Michele Berlanda  Massimo Bucci  Silvia Ferro  Roberta Rasotto  Roberto Busetto  Ilaria Iacopetti 《Acta veterinaria Scandinavica》2013,55(1):62

Dermoid sinus, a congenital malformation of neural tube development, has been reported in humans and several animal species including dogs. It is typically found in the dorsal midline and commonly occurs in the Rhodesian Ridgeback breed. A case of multiple dermoid sinuses in the fronto-occipital region is described. An 11-month-old, intact female Saint Bernard dog was presented with a 2 day history of discharge from a large irregular subcutaneous mass in the fronto-occipital region. The dog was otherwise healthy. The dog had two circular skin lesions (approximately 4 × 4 and 4 × 2 cm diameter) surrounded by multiple irregular elevated masses. The masses had multiple small openings on the skin surface with tufts of hair protruding from the apertures. The masses were surgically removed, and the diagnosis of multiple dermoid sinuses was confirmed by histological examination. Histopathological examination showed multiple, variably sized, spherical to tubular cysts expanding the dermis and subcutis. Cysts were filled with hair shafts and lamellar keratin and were lined by a stratified squamous epithelium. Sebaceous and apocrine gland adnexal structures were also observed. To the best of our knowledge, this is the first reported case of multiple dermoid sinuses of two different types in the head of a Saint Bernard dog.  相似文献   

Pocket technique or pocket technique combined with modified orbital rim anchorage for the replacement of a prolapsed gland of the third eyelid in dogs: 353 dogs          下载免费PDF全文

Domenico Multari  Anna Perazzi  Barbara Contiero  Giada De Mattia  Ilaria Iacopetti 《Veterinary ophthalmology》2016,19(3):214-219

The aim of this retrospective study was to evaluate the results obtained in 353 dogs (420 eyes) using two different surgical techniques for correction of a prolapsed gland of the third eyelid: the Morgan's pocket technique and a technique combining Morgan's approach with a slightly modified periosteal anchoring technique of Stanley and Kaswan. The pocket technique was used in 234 eyes and the combined technique in 186 eyes. Successful repositioning was obtained in 95% of all cases, with recurrence occurring in 5%. The recurrence rate in large breed dogs such as the English Bulldog and Boxer was lower with the combined technique than with the pocket technique.  相似文献   

Spatial distribution of Collembola in presence and absence of a predator     

Ilaria Negri 《Pedobiologia》2004,48(5-6):585-588

Many Collembola species are characterised by an aggregative behaviour, which is closely related to communication and co-ordination between individuals. In spite of a general heavy predation pressure, a large number of Collembola is found in soil suggesting that they have developed defence strategies against predators.

This study investigates changes in spatial structure of gregarious Collembola species in presence of a predator. It is analysed if the gregarious lifestyle of Collembola populations functions as a defence strategy against predation. In presence of a predator distances between individuals in the Collembola species Folsomia candida and Heteromurus tetrophthalmus became closer, reducing the risk of individuals to be captured by predators. On the contrary, Onychiurus sinensis specimens, which were never caught probably because of the extrusion of repelling fluids by means of their pseudocelli, moved away from each another. Besides being a successful chemical defence against predation, repelling fluid secretion may effectively repel conspecifics, thereby keeping individuals at greater distance.  相似文献   

An integrated approach for cetacean knowledge and conservation in the central Mediterranean Sea using research and social media data sources     

Daniela Silvia Pace  Giancarlo Giacomini  Ilaria Campana  Miriam Paraboschi  Giuliana Pellegrino  Margherita Silvestri  Jessica Alessi  Dario Angeletti  Valentina Cafaro  Gianni Pavan  Giandomenico Ardizzone  Antonella Arcangeli 《水产资源保护:海洋与淡水生态系统》2019,29(8):1302-1323

Widespread diffusion of genotype 3 hepatitis E virus among farming swine in Northern Italy     

Di Bartolo I  Martelli F  Inglese N  Pourshaban M  Caprioli A  Ostanello F  Ruggeri FM 《Veterinary microbiology》2008,132(1-2):47-55

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From landraces to modern cultivars: field observations on taro <Emphasis Type="Italic">Colocasia esculenta</Emphasis> (L.) Schott in sub-Saharan Africa     

Ilaria Maria Grimaldi  Walter N. Leke  Israel Borokini  Daniel Wanjama  Tinde Van Andel 《Genetic Resources and Crop Evolution》2018,65(7):1809-1828

Until recently, taro Colocasia esculenta (L.) Schott, was considered a neglected food crop due to its low palatability and inferior value compared to other root crops such as cassava, potatoes and yams. Under the impulse of new studies on plant dispersal, and in light of the severe threats posed by pests to its conservation status, this crop has finally received more attention. However, there is still insufficient knowledge on specific cultivars and their culinary and medicinal uses, especially in Africa. We studied the agrodiversity of taro cultivars in Nigeria, Cameroon, the Democratic Republic of Congo, Kenya, and Tanzania. Here, we present ethnobotanical, morphological and linguistic data of 20 taro cultivars, as well as specific notes on abandoned landraces. These traditional varieties represent valuable genetic resources and can be instrumental in protecting taro from the genetic erosion caused by preference for yautia, and diseases such as the leaf blight. With this work, we call for renewed efforts to conserve this species and its landraces.  相似文献   

The mouse model is suitable for the study of viral factors governing transmission and pathogenesis of highly pathogenic avian influenza (HPAI) viruses in mammals     

Michela Rigoni  Anna Toffan  Elisabetta Viale  Marzia Mancin  Filippo Cilloni  Elena Bertoli  Angela Salomoni  Sabrina Marciano  Adelaide Milani  Bianca Zecchin  Ilaria Capua  Giovanni Cattoli 《Veterinary research》2010,41(5)

Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtype pose a major public health threat due to their capacity to cross the species barrier and infect mammals, for example dogs, cats and humans. In the present study we tested the capacity of selected H7 and H5 HPAI viruses to infect and to be transmitted from infected BALB/c mice to contact sentinels. Previous experiments have shown that viruses belonging to both H5 and H7 subtypes replicate in the respiratory tract and central nervous system of experimentally infected mice. In this study we show that selected H7N1 and H5N1 HPAI viruses can be transmitted from mouse-to-mouse by direct contact, and that in experimentally infected animals they exhibit a different pattern of replication and transmission. Our results can be considered as a starting point for transmission experiments involving other influenza A viruses with α 2-3 receptor affinity in order to better understand the viral factors influencing transmissibility of these viruses in selected mammalian species.  相似文献