Atherosclerosis and inflammation     

Williams KJ  Tabas I 《Science (New York, N.Y.)》2002,297(5581):521-522

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Uptake and bioconcentration of dieldrin,dimethoate, and permethrin by Tetrahymena pyriformis     

Pradeep Bhatnagar  Surendar Kumar  Rup Lal 《Water, air, and soil pollution》1988,40(3-4):345-349

A ciliate protozoan, Tetrahymenapyriformis was exposed to three insecticides, dieldrin, dimethoate, and permethrin for 12 hr to study the uptake and bioconcentration potential. Ciliates concentrated 922, 3547, and 1056 gg g^?1 dry wt. over an initial concentration of 1 gg mL^?1 of dieldrin, dimethoate, and permethrin, respectively. The highest bioconcentration factor for three insecticides was 2095, 3547, and 1110, respectively. It is suggested that if levels in the environment reach 1 gg mL^?1 the chief effects would be reduction of cell population, and accumulation of the toxicants by ciliates. Accumulation of insecticides by ciliates would permit the toxicants to enter aquatic food chains. Thus the compounds could exert toxic effects at higher trophic levels.  相似文献   

APPLIED VETERINARY HISTOLOGY. SECOND EDITION          下载免费PDF全文

M.K. Bhatnagar 《Canadian journal of veterinary research》1988,52(3):398

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Fatty haemorrhagic liver syndrome in laying hens on diets supplemented with rapeseed products.     

S Yamashiro  M K Bhatnagar  J R Scott  S J Slinger 《Research in veterinary science》1975,19(3):312-321

Livers of laying hens of Hy-Line No 934E on low erucic acid rapeseed meals and rapeseed oil were studied. Gross lesions in the livers of hens on experimental diets were moderate to severe fatty degeneration, focal necrosis and moderate to severe haemorrhage. Histological examination revealed oedematous foci and lysis of hepatocytes along with large amounts of lipid droplets in the necrotic lesions. Necrotic lesions were not always associated with large haemorrhages. Connective tissue infiltration of older degenerative and haemorrhagic lesions was not extensive. Abdominal haemorrhage from livers occurred when extensive necrosis in the form of hepatocyte lysis and some vascular changes were present, suggesting hepatocytic degeneration caused by toxic products or their metabolites present in rapeseed by-products.  相似文献   

Wheat root distribution,water extraction pattern and grain yield as influenced by time and rate of irrigation     

T.N. Chaudhary  V.K. Bhatnagar 《Agricultural Water Management》1980,3(2):115-124

The effect of first irrigation (26, 40 and 54 days after seeding) and the rate of irrigation (5.5, 7.5 and 9.5 cm) applied subsequently at $\text{IW}\text{E}{}_{\mathrm{<mtext>pan</mtext>}}$ ratio of 0.9 on wheat root distribution, water extraction pattern and grain yield was studied on a barrier-free, sandy loam soil. The crop developed a more extensive root system when the first irrigation was applied after 26 days than after 40 and 54 days. With the first irrigation on the 26th day, the crop, receiving subsequent irrigations less frequently but at a heavier rate, developed a deeper root system than the crop receiving frequent, light irrigations. The water extraction pattern corresponded with the root distribution pattern. A relatively small difference in root density in the deeper layers caused a greater difference in soil water content than in the upper layers. Light and frequent irrigations produced maximum grain yields. However, for developing an extensive root system and enhancing water utilization in the subsoil, an early, light irrigation with subsequent irrigations applied less frequently at a relatively heavier rate seems desirable.  相似文献   

Ultrastructural alterations in the kidneys of Pekin ducks fed methylmercury.          下载免费PDF全文

S M Snelgrove-Hobson  P V Rao    M K Bhatnagar 《Canadian journal of veterinary research》1988,52(1):89-98

Ultrastructural alterations in the kidneys of Pekin ducks were studied after subchronic exposure to methylmercury chloride. Twenty-four male and twenty-four female Pekin ducks, 12 weeks of age were fed 0.0 (control), 0.5, 5.0 and 15.0 parts per million of MeHgCl, mixed in a mash diet for 12 weeks. Birds were observed for clinical signs daily. Kidneys were fixed in situ by perfusion with 4% glutaraldehyde in 0.05 M phosphate buffer and routinely processed for electron microscopy. Only minor morphological changes were observed in the renal corpuscle of ducks in the 0.5 ppm group. The component cells of the renal corpuscle in the 5.0 and 15.0 ppm groups showed several ultrastructural alterations, including an increase in number and size of lysosomes and vacuoles in podocytes and mild vacuolation in mesangial cells. The juxtaglomerular cells of afferent arterioles had crystallized granules. No significant changes were observed in glomerular basement membrane thickness and width of podocyte pedicels. The proximal tubules of the 5.0 and 15.0 ppm groups showed some microvillar loss and an increase in the number and size of lipid droplets, vacuoles and lysosomal bodies. The distal tubular changes in the 5.0 and 15 ppm groups included electron lucency and vacuolation of cytoplasm as well as occasional mitochondrial swelling. The collecting ducts of 5.0 ppm and 15.0 ppm groups showed varying degrees of degenerative changes in both mucus secretory as well as absorptive cells. These results suggest that subchronic exposure of Pekin ducks to methylmercury chloride causes subtle ultrastructural changes in renal corpuscle and marked ultrastructural changes in proximal tubules and collecting ducts.  相似文献   

Histopathologic and electron microscopic studies on the acute toxicity of ochratoxin A in rats   总被引：1，自引：0，他引：1  

M A Albassam  S I Yong  R Bhatnagar  A K Sharma  M G Prior 《Veterinary pathology》1987,24(5):427-435

Ochratoxin A was given by gavage to male rats. Moribund and dead animals were necropsied, and the surviving rats, including the controls, were killed 48 hours after dosing. Many of the principal rats were moribund, or began dying, within 12 to 24 hours after dosing. Lesions suggestive of disseminated intravascular coagulation were seen by light microscopy as early as 12 hours after dosing; fibrin deposits were in the spleen, brain choroid plexus, glomerular capillaries, liver, and heart. Renal tubular nephrosis, hepatic and lymphoid necrosis, and necrotic enteritis with villous atrophy were also seen. Electron microscopy demonstrated fibrin strands mixed with degranulated platelets, necrotic leukocytes, and swollen endothelial cells in glomerular capillaries. Myocardial changes included focal supercontracted sarcomeres adjacent to intercalated disks. Swollen sarcolemma, lysed myofibrils and fragmented Z-bands with interstitial edema, vascular thrombosis, and endothelial damage were also seen. The acute pathologic changes induced by ochratoxin A in the intestine, liver, and lymphoid tissues were more obvious than the tubular nephrosis, and the development of a disseminated intravascular coagulation-like syndrome with myocardial changes was a complicating factor.  相似文献   

Some observations in sheep during antirabic vaccine production     

M L Kalia  V K Bhatnagar  A S Grewal 《The Indian veterinary journal》1967,44(2):104-109

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Public health. Community studies for vaccinating schoolchildren against influenza     

Halloran ME  Longini IM 《Science (New York, N.Y.)》2006,311(5761):615-616

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A NOVEL,REMOVABLE, CERROBEND,BEAM‐BLOCKING DEVICE FOR RADIATION THERAPY OF THE CANINE HEAD AND NECK: PILOT STUDY          下载免费PDF全文

Michael S. Kent  Davide Berlato  Isabelle Vanhaezebrouck  Ira K. Gordon  Katherine S. Hansen  Alain P. Theon  Randall W. Holt  Earl A. Trestrail 《Veterinary radiology & ultrasound》2017,58(1):100-105

Radiation therapy of the head and neck can result in mucositis and other acute affects in the oral cavity. This prospective pilot study evaluated a novel, intraoral, beam‐blocking device for use during imaging and therapeutic procedures. The beam‐blocking device was made from a metal alloy inserted into a coated frozen dessert mold (Popsicle® Mold, Cost Plus World Market, Oakland, CA). The device was designed so that it could be inserted into an outer shell, which in turn allowed it to be placed or removed depending on the need due to beam configuration. A Farmer type ionization chamber and virtual water phantom were used to assess effects of field size on transmission. Six large breed cadaver dogs, donated by the owner after death, were recruited for the study. Delivered dose at the dorsal and ventral surfaces of the device, with and without the alloy block in place, were measured using radiochromic film. It was determined that transmission was field size dependent with larger field sizes leading to decreased attenuation of the beam, likely secondary to scatter. The mean and median transmission on the ventral surface without the beam‐blocking device was 0.94 [range 0.94–0.96]. The mean and median transmission with the beam‐blocking device was 0.52 [range 0.50–0.57]. The mean and median increase in dose due to backscatter on the dorsal surface of the beam‐blocking device was 0.04 [range 0.02–0.04]. Findings indicated that this novel device can help attenuate radiation dose ventral to the block in dogs, with minimal backscatter.  相似文献