Plasma angiotensin converting enzyme activity and pharmacokinetics of benazepril and benazeprilat in cats after single and repeated oral administration of benazepril.HCl     

King JN  Humbert-Droz E  Maurer M 《Journal of veterinary pharmacology and therapeutics》1999,22(6):360-367

The plasma pharmacokinetics of benazepril and its active metabolite, benazeprilat, were determined in cats after oral administration of benazepril.HCl at dosages of 0.25, 0.5 and 1.0 mg/kg as a single dose (n = 5 per group) and after once daily application for 8 days (n = 6 per group). Pharmacodynamics were assessed by measurement of plasma angiotensin converting enzyme (ACE) activity. After single administration of benazepril.HCl, maximum benazepril concentrations were recorded at the first sample (2 h) and declined relatively rapidly with an elimination half life (t1/2) of 1.4 h. Highest benazeprilat concentrations were recorded at the first sample (2 h) in most cats and declined biphasically with half lives of each phase of 2.4 and 27.7 h. With repeated administration, plasma benazeprilat concentrations accumulated slightly with accumulation ratios (R) of 1.46, 1.36 and 1.24 for the 0.25, 0.5 and 1.0 mg/kg dosages of benazepril.HCl, respectively (median value of 1.36 for all dosages). All three dosages of benazepril.HCl caused marked inhibition of plasma ACE activity in all cats. The maximum effect (Emax, % inhibition of ACE as compared to baseline) was > or = 98% after single and 100% with repeated administration. The duration of action of benazepril.HCl was long, with > 87% (single) and > 90% (repeat) inhibition of plasma ACE persisting 24 h after dosing. Benazepril.HCl was well tolerated in all animals. Dosages of 0.25-1.0 mg/kg benazepril.HCl once daily are recommended for clinical testing in cats.  相似文献   

Parasites of Dogs from Indian Settlements in Northwestern Canada: A Survey with Public Health Implications   总被引：1，自引：1，他引：0       下载免费PDF全文

D. H. A. Unruh  J. E. King  J. R. Allen    R. D. P. Eaton 《Canadian journal of veterinary research》1973,37(1):25-32

A total of 959 faecal samples were obtained from dogs in 12 native communities in Northern Saskatchewan, Central and Northern Alberta and the Northwest Territories. All samples were examined using a flotation technique. Samples from an area of endemic human amoebic infections were also examined by a formol-ether sedimentation method. Eighteen necropsies were performed.

Entamoeba histolytica cysts were recovered from dog faeces at Loon Lake, Saskatchewan.

Toxocara canis had low incidence in Saskatchewan and Central Alberta, and appeared to be almost non-existent further North. Toxascaris leonina was found in all areas surveyed. Canine hookworm infections were plentiful in all areas, the highest incidence being recorded from Northern Alberta and Northwest Territories. Many Taenia (or Echinococcus) infections were found consistently in all areas. Only one infection with Dipylidium caninum was discovered.

Metorchis conjunctus infections were found to be common in the Saskatchewan reserves. Infections with Diphyllobothrium sp. were found in all communities with access to good fishing. One specimen of Dioctophyma renale was recovered at necropsy.

Infections with parasites of no known zoonotic importance such as Trichuris, Alaria and Isospora species were also recorded.

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The effects of variations in the amount of hay fed to cows on the size and number of the fat globules in the milk produced     

J O King 《The British veterinary journal》1972,128(4):184-188

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The effects of different bacterial infections causing mastitis on the yield and quality of cow's milk     

J O King 《The British veterinary journal》1969,125(2):57-62

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The effects of pelleting rations with and without an antibiotic on the growth rate of rabbits     

J O King 《The Veterinary record》1974,94(25):586-588

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Filtered-air positive-pressure (FAPP) brooding of broiler chickens   总被引：2，自引：0，他引：2  

D P Anderson  D D King  C S Eidson  S H Kleven 《Avian diseases》1972,16(1):20-26

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Successful,repeated non-surgical collection of blastocysts from virgin and repeat breeder heifers     

T. Linares  W. A. King  K. Larsson  I. Gustavsson  A. Bane 《Veterinary research communications》1980,4(1):113-118

A total of 55 non-surgical collections, 7 days after spontaneous heat, was made in 19 heifers. Recovery rate was 57% (17/30) from 10 repeat breeder heifers and 72% (18/25) from 9 virgin heifers, this difference was not significant. Fertilization rate in both groups was 94%. The eggs were always recovered in the first 100 ml of flushing medium. Mean lengths of oestrous cycle after non-surgical collection were, respectively, 16.9 and 18.1 days in repeat breeder and virgin heifers. This difference was not significant. However, the cycle in which the first collection was made was significantly shorter (P<.005) than the cycle immediately before the collections. Only 61% of possible eggs were non-surgically collected from 4 superovulated repeat breeder cows and no further eggs were found after slaughter, one to two hours later.  相似文献   

Microsporidiosis in the tuatara     

S K Liu  F W King 《Journal of the American Veterinary Medical Association》1971,159(11):1578-1582

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Fertility of beef cows treated during estrus with human chorionic gonadotrophin.          下载免费PDF全文

G J King  J W Macpherson 《The Canadian veterinary journal. La revue veterinaire canadienne》1973,14(9):221-222

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A method for preparation of chromosomes from bovine zygotes and blastocysts   总被引：2，自引：0，他引：2  

W. A. King  T. Linares  I. Gustavsson  A. Bane 《Veterinary research communications》1979,3(1):51-56

A simple technique for making chromosome preparations from zygotes and early blastocysts is described. The morphological features of blastocysts and total number of cells greatly influence the quality of the preparation.  相似文献