Antibody synthesis initiated in vitro by paired explants of spleen and thymus   总被引：7，自引：0，他引：7  

G C Saunders  D W King 《Science (New York, N.Y.)》1966,151(716):1390-1391

Primary in vitro synthesis of antibody has been achieved with a mouse spleen-thymus organ culture system 54 hours after it was incubated for 18 hours with coliphage R17.  相似文献   

A Fluted Point from the Uptar Site, Northeastern Siberia     

ML King  SB Slobodin 《Science (New York, N.Y.)》1996,273(5275):634-636

Lanceolate bifacial points, including one fluted specimen, have been collected from beneath an early Holocene tephra at the Uptar site, northeastern Siberia. Thus, the technology associated with the well-known Paleoindian tradition was not confined to the Americas. The Uptar collection does not compare readily with other Beringian complexes and demonstrates that there is greater diversity in the archaeological record of northeastern Siberia than traditional colonization models imply.  相似文献   

African hot spot volcanism: small-scale convection in the upper mantle beneath cratons   总被引：2，自引：0，他引：2  

King SD  Ritsema J 《Science (New York, N.Y.)》2000,290(5494):1137-1140

Numerical models demonstrate that small-scale convection develops in the upper mantle beneath the transition of thick cratonic lithosphere and thin oceanic lithosphere. These models explain the location and geochemical characteristics of intraplate volcanos on the African and South American plates. They also explain the presence of relatively high seismic shear wave velocities (cold downwellings) in the mantle transition zone beneath the western margin of African cratons and the eastern margin of South American cratons. Small-scale, edge-driven convection is an alternative to plumes for explaining intraplate African and South American hot spot volcanism, and small-scale convection is consistent with mantle downwellings beneath the African and South American lithosphere.  相似文献   

Mutations in dynein link motor neuron degeneration to defects in retrograde transport     

Hafezparast M  Klocke R  Ruhrberg C  Marquardt A  Ahmad-Annuar A  Bowen S  Lalli G  Witherden AS  Hummerich H  Nicholson S  Morgan PJ  Oozageer R  Priestley JV  Averill S  King VR  Ball S  Peters J  Toda T  Yamamoto A  Hiraoka Y  Augustin M  Korthaus D  Wattler S  Wabnitz P  Dickneite C  Lampel S  Boehme F  Peraus G  Popp A  Rudelius M  Schlegel J  Fuchs H  Hrabe de Angelis M  Schiavo G  Shima DT  Russ AP  Stumm G  Martin JE  Fisher EM 《Science (New York, N.Y.)》2003,300(5620):808-812

Degenerative disorders of motor neurons include a range of progressive fatal diseases such as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal muscular atrophy (SMA). Although the causative genetic alterations are known for some cases, the molecular basis of many SMA and SBMA-like syndromes and most ALS cases is unknown. Here we show that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology. These mutations exclusively perturb neuron-specific functions of dynein.  相似文献   

AN ARTIFICIAL ROOT FOR INDUCING CAPILLARY MOVEMENT OF SOIL MOISTURE     

King FH 《Science (New York, N.Y.)》1904,20(516):680-681

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Effect of Chemical Treatment Prior to Storage on Viability and Growth of Cottonseed     

Lambou MG  King GS  Condon MZ 《Science (New York, N.Y.)》1948,108(2812):563-564

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Risk factors in breast cancer     

King MC 《Science (New York, N.Y.)》1981,214(4525):1122-1123

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Science and government. Taking science out of the box--foresight recast     

King DA  Thomas SM 《Science (New York, N.Y.)》2007,316(5832):1701-1702

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Extragalactic astronomy     

King IR 《Science (New York, N.Y.)》1977,195(4277):481-482

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Comment on "Preserved feedforward but impaired top-down processes in the vegetative state"     

King JR  Bekinschtein T  Dehaene S 《Science (New York, N.Y.)》2011,334(6060):1203; author reply 1203

Boly et al. (Reports, 13 May 2011, p. 858) investigated cortical connectivity patterns in patients suffering from a disorder of consciousness, using electroencephalography in an auditory oddball paradigm. We point to several inconsistencies in their data, including a failure to replicate the classical mismatch negativity. Data quality, source reconstruction, and statistics would need to be improved to support their conclusions.  相似文献