A contribution to the epidemiology of parasitic gastro-enteritis in lambs     

G B Heath  J F Michel 《The Veterinary record》1969,85(11):305-308

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Metabolism of benomyl in carrot,strawberry and apple     

Jean P. Rouchaud  Georges J. Lhoest  Michel J. Mercier  Joseph A. Meyer 《Pest management science》1977,8(1):23-30

The metabolism of benomyl was studied in carrots treated with high rates of benomyl, and in strawberries and apples treated at normal rates. The same metabolites were observed in both cases though, at normal rates, their concentrations were low but significant. Detected by means of gas-liquid chromatography they were: carbendazim, 2-aminobenzimidazole (2-AB), benzimidazole, 2-aminobenzonitrile, o-phenylene-diamine and the conjugates of carbendazim and 2-AB. o-Phenylenediamine has not hitherto been reported as a metabolite of benomyl. Two unidentified compounds were also observed by gas-liquid chromatography; their mass spectra were obtained by means of combined gas-liquid chromatography and mass spectrometry.  相似文献   

La vallee alluviale du Senegal (Afrique de l'ouest). Relations geomorphologie - sols - aptitudes culturales et leur cartographie au 1/50 000     

P. Michel  J.H. Durand 《CATENA》1978,5(2):213-225

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Sperm storage in the oviduct of the domestic fowl with special reference to sperm nests in the uterovaginal area     

G Michel 《Anatomia, histologia, embryologia》1987,16(3):254-258

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Field observations on the epidemiology of parasitic gastro-enteritis in calves   总被引：1，自引：0，他引：1  

J F Michel  M B Lancaster  C Hong 《Research in veterinary science》1970,11(3):255-259

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Using 3D animations to teach intracellular signal transduction mechanisms: taking the arrows out of cells     

Buchanan MF  Carter WC  Cowgill LM  Hurley DJ  Lewis SJ  MacLeod JN  Melton TR  Moore JN  Pessah I  Roberson M  Robertson TP  Smith ML  Vandenplas ML 《Journal of veterinary medical education》2005,32(1):72-78

Traditional methods of teaching intracellular biological processes and pathways use figures or flowcharts with the names of molecules linked with arrows. Many veterinary students, presented with such material, simply memorize the names or chemical structures of the molecules and are then likely to forget the material once the examination is completed. To address this problem, the authors designed, created, and field-tested new teaching media that incorporate realistic three-dimensional (3D) animations depicting the dynamic changes that occur in intracellular molecules during cellular activation. Testing found that veterinary students taught using traditional teaching media (e.g., lectures, handouts, textbooks) are proficient in memorizing the names and order of intracellular molecules but unable to appreciate the interactions between these elements or their spatial relationships within cells. In contrast, more than 90% of veterinary students taught using 3D animations not only recall the facts about the intracellular elements but also develop accurate mental images of the interactions among these molecules and their spatial relationships. These findings strongly suggest that the comprehension of complex biological processes by veterinary students can be enhanced by the use of dynamic 3D depictions of these processes in the classroom.  相似文献   

Serologic survey of cats and dogs during an epidemic of West Nile virus infection in humans     

Kile JC  Panella NA  Komar N  Chow CC  MacNeil A  Robbins B  Bunning ML 《Journal of the American Veterinary Medical Association》2005,226(8):1349-1353

OBJECTIVE: To estimate West Nile virus (WNV) infection rates, assess environmental variables that correlated with seropositivity in dogs and cats, and assess whether pets should be considered as possible sentinels for WNV and therefore of potential human exposure. DESIGN: Cross-sectional serosurvey. ANIMALS: 442 dogs and 138 cats. PROCEDURE: Serum samples were screened for seropositivity against WNV by use of the plaque reduction neutralization test. RESULTS: 116 (26%) dogs and 13 (9%) cats yielded positive results. The odds of seropositivity against WNV for outdoor-only family dogs were almost 19 times as great as those for indoor-only family dogs and almost twice as great for stray dogs as for family dogs. Family dogs not receiving heartworm medication were 2.5 times as likely to yield positive results for antibodies against WNV as family dogs receiving heartworm medication. CONCLUSIONS AND CLINICAL RELEVANCE: Seropositivity was greater for outdoor family dogs than for indoor family dogs. Further investigation of the potential use of stray dogs as sentinel indicators for WNV infection and the potential risk of human exposure is warranted.  相似文献   

Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants     

Dacasto M  Eeckhoutte C  Capolongoa F  Dupuy J  Carletti M  Calléja C  Nebbia C  Alvinerie M  Galtier P 《Veterinary research》2005,36(2):179-190

The cytochrome P450 (P450) superfamily represents a group of relevant enzymes in the field of drug metabolism and several exogenous or constitutional factors contribute to regulate its expression. Cattle represent an important source of animal-derived food-products and studies concerning the P450 expression are needed for the extrapolation of pharmacotoxicological data from one species to another and for the evaluation of the consumer's risk associated with the consumption of harmful residues found in foodstuffs. In the present study, possible breed-, gender- and species-differences in P4503A (the P450 subfamily more expressed in the human liver) expression were studied in vitro in Piedmontese (PDM) and Limousin (LIM) meat cattle breeds of both sexes and in domestic Ruminants (cattle, sheep and goats). Cytochrome P450 and P4503A contents as well as CYP3A-dependent drug metabolising enzymes (DME) were measured in liver microsomes. Significant lower levels of P450 (P < 0.001) and P4503A (P < 0.05) contents were observed in PDM vs. LIM of both sexes; the P4503A-dependent DME activities were significantly (P values ranging from 0.05 up to 0.001) higher in PDM cattle, particularly in males. A gender-effect in DME activities was noticed (P < 0.05) only in PDM male cattle. With regards to the species, the expression of both P4503A apoprotein and some of the related DME activities were more pronounced in sheep (P < 0.01 vs. cattle) and in goats (P < 0.05 vs. sheep; P < 0.01 vs. cattle) than in cattle. The significant differences in P4503A expression observed in LIM and PDM cattle are consistent with previously published data on strain- and breed-differences pointed out in rats and men. As far as a possible sex-effect is concerned, no clear-cut evidence is likely to be drawn. Finally, P4503A expression was more relevant in small ruminants.  相似文献   

Concentrations of serum amyloid A and lipopolysaccharide-binding protein in horses with colic     

Vandenplas ML  Moore JN  Barton MH  Roussel AJ  Cohen ND 《American journal of veterinary research》2005,66(9):1509-1516

OBJECTIVE: To determine concentrations of 2 acute-phase proteins (serum amyloid A [SAA] and lipopolysaccharide-binding protein [LBP]) in serum samples obtained from horses with colic and identify relationships among these acute-phase proteins and clinical data. ANIMALS: 765 horses with naturally developing gastrointestinal tract diseases characterized by colic (ie, clinical signs indicative of abdominal pain) and 79 healthy control horses; all horses were examined at 2 university teaching hospitals. PROCEDURE: Serum concentrations of SAA and LBP were determined by immunoturbidometric and dot-blot assays, respectively. RESULTS: SAA and LBP concentrations were determined for 718 and 765 horses with colic, respectively. Concentrations of SAA were significantly higher in nonsurvivors than in survivors, and horses with enteritis or colitis and conditions characterized by chronic inflammation (eg, abdominal abscesses, peritonitis, or rectal tears) had SAA concentrations significantly greater than those for horses with other conditions. Serum concentrations of LBP did not correlate with outcome, disease process, or portion of the gastrointestinal tract affected. CONCLUSIONS AND CLINICAL RELEVANCE: Circulating concentrations of SAA were significantly higher at admission in horses with colic attributable to conditions having a primary inflammatory cause (eg, enteritis, colitis, peritonitis, or abdominal abscesses) and were higher in horses that failed to survive the episode of colic, compared with concentrations in horses that survived. Serum concentrations of LBP did not correlate with survival. Analysis of these findings suggests that evaluation of SAA concentrations may be of use in identifying horses with colic attributable to diseases that have inflammation as a primary component of pathogenesis.  相似文献   

Blood vessels in cattle teats     

G Michel 《Archiv fuer experimentelle veterinaermedizin》1977,31(4):471-476

The behaviours of arteries and veins in the teats of cattle of different age groups is described against the background of general formation and development of the vessels. Growing age was found to have been accompanied by numerical growth of veins (rather than arteries) towards the teat tip and by some thickening of the median vein region. No correlations were established between those vascular changes, on the one hand, and milkability, on the other.  相似文献