A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine     

Masaharu HISASUE  Mina TANAKA  Sakurako NEO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(1):142

A 5-year-old female cat with nonregenerative anemia and thrombocytopenia was diagnosed with myelodysplastic syndromes (MDS), since peripheral blood and bone marrow (BM) examination revealed various dysplasias and a blast ratio of 19%. Chemotherapy with azacytidine (AZA; 70–35 mg/m², 3–5 days, three cycles) and treatment with prednisolone, antibiotics, and vitamin K2, and blood transfusion were performed. On day 106, blast cells and dysplasia had decreased in the BM, and the cat remained alive for at least 1,474 days. This report is the first on feline MDS treated with AZA, suggesting appropriate drug dosage, interval and effective combination should be investigated and the pharmacological and cell biological mechanisms needs to be elucidated in the future.  相似文献   

Potassium Fixation and Release in Some Calcareous Soils under Orange Cultivation     

Mahdi Najafi-Ghiri  Boostani  Hamid Reza  Mirsoleimani  Abbas  Mohaviye-Asadi  Negin  Beizavi  Majid  Shafiei  Mina  Mirdoraghi  Maryam 《Eurasian Soil Science》2020,53(7):978-985

Eurasian Soil Science - Arid and semiarid soils of southern Iran may fix a large content of applied potassium (K), but the fixed K may be gradually supplied to plants. Sixteen representative soils...  相似文献   

Group G type X: A new antigenic combination in streptococci isolated from cases of bovine mastitis in Israel     

Sonya Bergner-Rabinowitz  Mina Ferne  S. Fleiderman  G. Ziv  A. Saran  Marta Winkler 《Veterinary microbiology》1981,6(4):383-387

The presence of type X protein antigen was discovered in group G streptococci. This antigen appears to be related to infection in the bovine udder. In contrast to group B type specific polysaccharide antigens, the type X protein antigen seems to be unrelated to human infection. The importance of this phenomenon in epidemiology is suggested.  相似文献   

An estuarine neritid gastropod, Clithon corona, a potential reservoir of thermostable direct hemolysin-producing Vibrio parahaemolyticus     

Velammal A  Kato M  Miyagi S  Toyozato M  Kumazawa NH 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(8):833-835

An estuarine neritid gastropod, Clithon corona, maintained in UV-irradiated recirculating artificial seawater with a salinity of 15 per mil (%o) was found to retain thermostable direct hemolysin (TDH)-producing Vibrio parahaemolyticus in the gut at significantly higher levels than TDH-non-producing one for at least 14 days. Another estuarine neritid gastropod, C. sowerbianus, was not able to support the preferential survival of TDH-producing organisms. This evidence suggests that, if TDH-producing vibrios are brought to estuaries inhabited by C. corona, repeated ingestion of V. parahaemolyticus by this gastropod could lead to accumulation of TDH-producing vibrios in the estuaries.  相似文献   

Spontaneous neoplasia in four captive greater hedgehog tenrecs (Setifer setosus)     

Mina K Khoii  Elizabeth W Howerth  Roy B Burns  K Paige Carmichael  Zoltan S Gyimesi 《Journal of zoo and wildlife medicine》2008,39(3):392-397

Little information is available about diseases and pathology of species within the family Tenrecidae, including the greater hedgehog tenrec (Setifer setosus), a Madagascan insectivore. This report summarizes necropsy and histopathologic findings of neoplasia in four captive greater hedgehog tenrecs. Although only four animals are included in this report, neoplasia seems to be a common and significant source of morbidity and mortality in greater hedgehog tenrecs. Types of neoplasia identified include a thyroid follicular-solid carcinoma, two urinary bladder transitional cell carcinomas, uterine endometrial polyps, and multicentric B-cell lymphoma. Due to small sample size, no etiology could be determined, but genetics, viral infection, pesticide treatment, nutrition, or other environmental factors might contribute to the development of neoplasia in this species. This is the first report of neoplasia in greater hedgehog tenrecs.  相似文献   

Ability of various water‐insoluble fertilizers to supply available phosphorus in hydroponics to plant species with diverse phosphorus‐acquisition efficiency: Involvement of organic acid accumulation in plant tissues and root exudates     

Javier Erro  Angel Ma Zamarreo  Jose Ma García‐Mina 《植物养料与土壤学杂志》2010,173(5):772-777

Previous studies describe the suitability of a new type of phosphorus (P) fertilizer, called “rhizosphere‐controlled fertilizer” (RCF), to supply available P to plants while reducing soil phosphorus fixation. In order to explore the involvement of organic acid root exudation in P uptake from RCF, we investigated the relationship between shoot and root P concentrations, and the concentration of the main polycarboxylic organic acids in roots, shoots, and plant exudates. Plant species with different P‐acquisition efficiency (low: maize; medium: chickpea; high: lupin) were grown in hydroponics with three different P fertilizers: The water‐insoluble P fraction of RCF (RCF); Phospal, a slow‐release source of phosphate composed of calcium and aluminum phosphates (PH); monopotassiumphosphate (KP), and a control treatment without P (P–). RCF was as efficient as KP in supplying P to plants in the case of chickpea and lupin, and slightly less efficient than KP in maize. However, P from PH was not available for maize and less available compared to KP and RCF in chickpea and lupin. This variation reflects the different efficiencies in P acquisition for the three plant species. Except in the case of maize, plants receiving KP presented the lowest concentration of organic acids in roots and exudates, while those plants suffering severe P deficiency (P– and PH) showed the highest organic acid concentration. However, RCF had a high concentration of organic acids in roots and exudates, as well as a high P concentration in the shoot indicating that P uptake from RCF is enhanced due to root release and action of specific organic acids.  相似文献   

Thermo-mechanical and morphological properties of short natural fiber reinforced poly (lactic acid) biocomposite: Effect of fiber treatment     

A. K. M. Moshiul Alam  M. F. Mina  M. D. H. Beg  A. A. Mamun  A. K. Bledzki  Q. T. H. Shubhra 《Fibers and Polymers》2014,15(6):1303-1309

Untreated oil palm empty fruit bunch (REFB), alkali treated EFB (AEFB), ultrasound treated EFB (UEFB) and simultaneous ultrasound-alkali treated EFB (UAEFB) short fibers were incorporated in poly(lactic acid) (PLA) for fabricating bio-composites. The REFB fiber-PLA (REPC) and treated EFB (TEFB) fiber-PLA (TEPC) composites were prepared and characterized. Glass transition temperature, crystal melting temperature, decomposition temperature, melt flow index, density and mechanical properties (tensile strength, tensile modulus and impact strength) of TEPC are found to be higher than those of REPC. The observed crystallization temperature of TEPC is lower than that of REPC. Among all samples, TEPC prepared from UAEFB fiber shows better performances than other samples fabricated by REFB and AEFB fibers. Scanning electron microscopy, Fourier transform infrared spectroscopy and XRD analyses well support all the observed results.  相似文献   

Recombinant Production of a Novel Fusion Protein: Listeriolysin O Fragment Fused to S1 Subunit of Pertussis Toxin     

Hossein Forghani  Mahin Jamshidi Makiani  Hossein Zarei Jaliani  Mina Boustanshenas  Seyed Mohsen Zahraei 《Iranian Biomedical Journal》2021,25(1):33

Background:Some resources have suggested that genetically inactivated PTs bear a more protective effect than chemically inactivated products. This study aimed to produce new version of PT, by cloning an inactive PTS1 in a fusion form with N-terminal half of the LLO pore-forming toxin. Methods:Deposited pdb structure file of the PT was used to model an extra disulfide bond. Codon-optimized ORF of the PTS1 was used to make recombinant constructs of PTS1 and LLO-PTS1 in the pPSG-IBA35 vector. The recombinant PTS1 and LLO-PTS1 proteins were expressed in BL21 DE3 and SHuffle T7 strains of E. coli and purified by affinity chromatography. Cytotoxic effects of the recombinant proteins were examined in the MCF-7 cell line. Results:The purity of the products proved to be more than 85%, and the efficiency of the disulfide bond formation in SHuffle T7 strain was higher than BL21 DE3 strain. No cytotoxicity of the recombinant proteins was observed in MCF-7 cells. Soluble recombinant PTS1 and LLO-PTS1 proteins were produced in SHuffle T7 strain of E. coli with high efficiency of disulfide bonds formation. Conclusion:The LLO-PTS1 with corrected disulfide bonds was successfully expressed in E. coli SHuffle T7 strain. Due to the safety for human cells, this chimeric molecule can be an option to prevent pertussis disease if its immunostimulatory effects would be confirmed in the future. Key Words: Adjuvant, Cloning, Fusion protein, Pertussis toxin  相似文献   

Classification of chemoautotrophic ammonia-oxidizing bacteria using pyruvate kinase genes as high resolution phylogenetic markers     

Takeshi IDA  Reiji TAKAHASHI  Kazuo SATOH  Mina KOGURE  Tatsuaki TOKUYAMA 《Soil Science and Plant Nutrition》2006,52(3):284-290

  相似文献   

Genome-Wide Identification of Zn_2Cys_6 Class Fungal-Specific Transcription Factors(ZnFTFs) and Functional Analysis of UvZnFTF1 in Ustilaginoidea virens     

Tianqiao Song  Xiong Zhang  You Zhang  Dong Liang  Jiaoling Yan  Junjie Yu  Mina Yu  Huijuan Cao  Mingli Yong  Xiayan Pan  Zhongqiang Qi  Yan Du  Rongsheng Zhang  Yongfeng Liu 《水稻科学》2021,28(6):567-578

  相似文献