Influence of ampicillin, ceftiofur, attenuated live PRRSV vaccine, and reduced dose Streptococcus suis exposure on disease associated with PRRSV and S. suis coinfection     

Schmitt CS  Halbur PG  Roth JA  Kinyon JM  Kasorndorkbua C  Thacker B 《Veterinary microbiology》2001,78(1):29-37

The objective of this research was to evaluate the efficacy of two antimicrobials (ampicillin and ceftiofur), a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine, and low dose exposure to Streptococcus suis on disease associated with PRRSV/S. suis coinfection. Fifty-six, crossbred, PRRSV-free pigs were weaned at 10-12 days of age and randomly assigned to five treatment groups. All pigs were inoculated with 2ml of 10(6.4) TCID50/ml of high virulence PRRSV isolate VR-2385 intranasally at 29-31 days of age (day 0 of the study) followed 7 days later by intranasal inoculation with 2ml of 10(8.9)colony forming units(CFU)/ml S. suis type 2 isolate ISU VDL #40634/94. Pigs in group 1 (n=10) served as untreated infected positive controls. Pigs in group 2 (n=12) were treated with 5.0 mg/kg ceftiofur hydrochloride intramuscularly (IM) on days 8, 11, and 14. Pigs in group 3 (n=11) were treated with 11 mg/kg ampicillin IM on days 8-10. Pigs in group 4 (n=12) were vaccinated 14 days prior to PRRSV challenge with a commercial modified-live PRRSV vaccine. Pigs in group 5 (n=11) were exposed to a 1:100 dilution of the S. suis challenge inoculum 19 days prior to S. suis challenge. Mortality was 80, 25, 82, 83, and 36% in groups 1-5, respectively. The reduced dose S. suis exposure had some residual virulence, evidenced by S. suis induced meningitis in two pigs after exposure. Treatment with ceftiofur hydrochloride and reduced dose exposure to S. suis were the only treatments which significantly (P<0.05) reduced mortality associated with PRRSV/S. suis coinfection, significantly (P<0.05) reduced recovery of S. suis from tissues at necropsy, and significantly (P<0.05) reduced the severity of gross lung lesions.  相似文献   

Molecular and biological characterisation of Cryptosporidium in pigs   总被引：1，自引：0，他引：1  

Morgan UM  Buddle JR  Armson A  Elliot A  Thompson RC 《Australian veterinary journal》1999,77(1):44-47

OBJECTIVE: Genetic and biological characterisation of 12 isolates of Cryptosporidium from pigs and comparing them with Cryptosporidium isolates from humans and cattle. DESIGN: Cryptosporidium isolates from pigs were compared with those obtained from human and cattle using rDNA sequence analysis. The infectivity of two of the porcine isolates was determined in neonatal mice and the clinical history of the infected pigs recorded. RESULTS: Pig-derived isolates of Cryptosporidium exhibited two distinct genotypes; a porcine genotype and a bovine genotype, which is common to cattle and other livestock. The porcine genotype did not produce any infection in neonatal mice whereas the bovine genotype did. CONCLUSION: Two distinct genetically and biologically differing strains of Cryptosporidium appeared to be associated with acute diarrhoea in pigs. Whether Cryptosporidium was a primary or secondary pathogen is unclear but warrants further investigation. As the bovine genotype is known to infect humans, the results suggest that pigs can act as reservoirs of cryptosporidial infections for humans and other live-stock. The zoonotic potential of the pig-adapted genotype is uncertain and requires further study.  相似文献   

Comparative in vitro activity of valnemulin against porcine bacterial pathogens   总被引：1，自引：0，他引：1  

Aitken IA  Morgan JH  Dalziel R  Burch DG  Ripley PH 《The Veterinary record》1999,144(5):128

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Relation of the white blood picture to intestinal helminth infestations in cats (felis domestica)     

B Roth  C C Schneider 《Berliner und Münchener tier?rztliche Wochenschrift》1971,84(22):436-437

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Spinal Dural Ossification in the Dog: Incidence and Distribution Based on a Radiographic Study1     

Joe P. Morgan 《Veterinary radiology & ultrasound》1969,10(1):43-48

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The large animal laboraotory--a proposed approach     

H C Morgan 《Journal of the American Veterinary Medical Association》1969,155(12):1821-1827

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Spondylosis Deformans in the Dog: Its Radiographic Appearance1     

Joe P. Morgan 《Veterinary radiology & ultrasound》1967,8(1):17-22

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Animal Physiologic Surgery          下载免费PDF全文

L. De Roth 《The Canadian veterinary journal. La revue veterinaire canadienne》1978,19(9):243

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Bienengesundheitsdienst          下载免费PDF全文

L. de Roth 《Canadian journal of veterinary research》1976,40(2):220

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Congenital Anomalies of the Vertebral Column of the Dog: A Study of the Incidence and Significance Based on a Radiographic and Morphologic Study1     

Joe P. Morgan 《Veterinary radiology & ultrasound》1968,9(1):21-29

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