Strategies of exploitation of mammalian reservoirs by Bartonella species     

Deng H  Le Rhun D  Buffet JP  Cotté V  Read A  Birtles RJ  Vayssier-Taussat M 《Veterinary research》2012,43(1):15

ABSTRACT: Numerous mammal species, including domestic and wild animals such as ruminants, dogs, cats and rodents, as well as humans, serve as reservoir hosts for various Bartonella species. Some of those species that exploit non-human mammals as reservoir hosts have zoonotic potential. Our understanding of interactions between bartonellae and reservoir hosts has been greatly improved by the development of animal models for infection and the use of molecular tools allowing large scale mutagenesis of Bartonella species. By reviewing and combining the results of these and other approaches we can obtain a comprehensive insight into the molecular interactions that underlie the exploitation of reservoir hosts by Bartonella species, particularly the well-studied interactions with vascular endothelial cells and erythrocytes.  相似文献   

Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors     

Bruno B. Chomel  Henri-Jean Boulouis  Edward B. Breitschwerdt  Rickie W. Kasten  Muriel Vayssier-Taussat  Richard J. Birtles  Jane E. Koehler    Christoph Dehio 《Veterinary research》2009,40(2)

Bartonella spp. are facultative intracellular bacteria that cause characteristic host-restricted hemotropic infections in mammals and are typically transmitted by blood-sucking arthropods. In the mammalian reservoir, these bacteria initially infect a yet unrecognized primary niche, which seeds organisms into the blood stream leading to the establishment of a long-lasting intra-erythrocytic bacteremia as the hall-mark of infection. Bacterial type IV secretion systems, which are supra-molecular transporters ancestrally related to bacterial conjugation systems, represent crucial pathogenicity factors that have contributed to a radial expansion of the Bartonella lineage in nature by facilitating adaptation to unique mammalian hosts. On the molecular level, the type IV secretion system VirB/VirD4 is known to translocate a cocktail of different effector proteins into host cells, which subvert multiple cellular functions to the benefit of the infecting pathogen. Furthermore, bacterial adhesins mediate a critical, early step in the pathogenesis of the bartonellae by binding to extracellular matrix components of host cells, which leads to firm bacterial adhesion to the cell surface as a prerequisite for the efficient translocation of type IV secretion effector proteins. The best-studied adhesins in bartonellae are the orthologous trimeric autotransporter adhesins, BadA in Bartonella henselae and the Vomp family in Bartonella quintana. Genetic diversity and strain variability also appear to enhance the ability of bartonellae to invade not only specific reservoir hosts, but also accidental hosts, as shown for B. henselae. Bartonellae have been identified in many different blood-sucking arthropods, in which they are typically found to cause extracellular infections of the mid-gut epithelium. Adaptation to specific vectors and reservoirs seems to be a common strategy of bartonellae for transmission and host diversity. However, knowledge regarding arthropod specificity/restriction, the mode of transmission, and the bacterial factors involved in arthropod infection and transmission is still limited.  相似文献   

Volumetric capnography to diagnose venous air embolism in an anaesthetised horse     

Muriel Sacks  Martina Mosing 《Veterinary anaesthesia and analgesia》2017,44(1):189-190

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Preliminary post-prandial studies of Burmese cats with elevated triglyceride concentrations and/or presumed lipid aqueous     

Elissa K. Kluger  Muriel Caslake  Randolph M. Baral  Richard Malik  Merran Govendir 《Journal of Feline Medicine and Surgery》2010,12(8):621-630

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THE EFFECT OF CHOPPING, LACERATING AND WILTING OF HERBAGE ON THE CHEMICAL COMPOSITION OF SILAGE     

J. C. Murdoch    D. A. Balch    Muriel C.  Holdsworth Marion  Wood 《Grass and Forage Science》1955,10(2):181-188

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Issues and special features of animal health research     

Ducrot C  Bed'hom B  Béringue V  Coulon JB  Fourichon C  Guérin JL  Krebs S  Rainard P  Schwartz-Cornil I  Torny D  Vayssier-Taussat M  Zientara S  Zundel E  Pineau T 《Veterinary research》2011,42(1):96

ABSTRACT: In the rapidly changing context of research on animal health, INRA launched a collective discussion on the challenges facing the field, its distinguishing features, and synergies with biomedical research. As has been declared forcibly by the heads of WHO, FAO and OIE, the challenges facing animal health, beyond diseases transmissible to humans, are critically important and involve food security, agriculture economics, and the ensemble of economic activities associated with agriculture. There are in addition issues related to public health (zoonoses, xenobiotics, antimicrobial resistance), the environment, and animal welfare.Animal health research is distinguished by particular methodologies and scientific questions that stem from the specific biological features of domestic species and from animal husbandry practices. It generally does not explore the same scientific questions as research on human biology, even when the same pathogens are being studied, and the discipline is rooted in a very specific agricultural and economic context.Generic and methodological synergies nevertheless exist with biomedical research, particularly with regard to tools and biological models. Certain domestic species furthermore present more functional similarities with humans than laboratory rodents.The singularity of animal health research in relation to biomedical research should be taken into account in the organization, evaluation, and funding of the field through a policy that clearly recognizes the specific issues at stake. At the same time, the One Health approach should facilitate closer collaboration between biomedical and animal health research at the level of research teams and programmes.  相似文献   

Biomechanical comparison of knotted and knotless stabilization techniques of the tarsal medial collateral ligament in cats: A cadaveric study     

Muriel Luescher  Philipp A. Schmierer DECVS  Brian H. Park PhD  Antonio Pozzi DECVS  DACVS  DACVSMR  Andreas Gutbrod DECVS  Rich Evans PhD  Sebastian C. Knell DECVS 《Veterinary surgery : VS》2020,49(2):390-400

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Genome Mining for Antimicrobial Compounds in Wild Marine Animals-Associated Enterococci     

Janira Prichula  Muriel Primon-Barros  Romeu C. Z. Luz  Ícaro M. S. Castro  Thiago G. S. Paim  Maurício Tavares  Rodrigo Ligabue-Braun  Pedro A. d&#x;Azevedo  Jeverson Frazzon  Ana P. G. Frazzon  Adriana Seixas  Michael S. Gilmore 《Marine drugs》2021,19(6)

New ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising. Further, host-associated microbes are of special interest because of their low toxicity and compatibility with host health. Here, we identified and characterized biosynthetic gene clusters encoding antimicrobial compounds in host-associated enterococci recovered from fecal samples of wild marine animals remote from human-affected ecosystems. Putative biosynthetic gene clusters in the genomes of 22 Enterococcus strains of marine origin were predicted using antiSMASH5 and Bagel4 bioinformatic software. At least one gene cluster encoding a putative bioactive compound precursor was identified in each genome. Collectively, 73 putative antimicrobial compounds were identified, including 61 bacteriocins (83.56%), 10 terpenes (13.70%), and 2 (2.74%) related to putative nonribosomal peptides (NRPs). Two of the species studied, Enterococcus avium and Enterococcus mundtti, are rare causes of human disease and were found to lack any known pathogenic determinants but yet possessed bacteriocin biosynthetic genes, suggesting possible additional utility as probiotics. Wild marine animal-associated enterococci from human-remote ecosystems provide a potentially rich source for new antimicrobial compounds of therapeutic and industrial value and potential probiotic application.  相似文献   

THE CHEMICAL COMPOSITION AND LOSS OF NUTRIENTS IN SILAGE MADE WITH THE ADDITION OF SODIUM METABISULPHITE AND HALOGENATED ACETATE OF GLYCOL     

J. C. Murdoch    Muriel C.  Holdsworth Marion  Wood 《Grass and Forage Science》1956,11(1):16-22

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Geoffrey Van Clief Houghland, 1897–1980     

Muriel J. O’Brien 《American Journal of Potato Research》1980,57(11):581-583

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