New phenolic compounds and antioxidant potential of Catharanthus roseus     

Ferreres F  Pereira DM  Valentão P  Andrade PB  Seabra RM  Sottomayor M 《Journal of agricultural and food chemistry》2008,56(21):9967-9974

Screening of the phenolic compounds from seeds, stems, leaves and petals of Catharanthus roseus (L.) G. Don (cv. Little Bright Eye) was achieved by HPLC-DAD-ESI-MS/MS. This is the first detailed study of noncolored phenolics in C. roseus, which allowed the characterization of three caffeoylquinic acids and fifteen flavonol glycosides (di- and trisaccharides of kaempferol, quercetin and isorhamnetin). Fifteen compounds are reported for the first time in this species. The scavenging ability of the different plant matrices was assessed against DPPH(*) radical and against reactive oxygen (superoxide radical) and a reactive nitrogen (nitric oxide) species. A concentration-dependent protective effect was observed for seeds and tissues, with petals shown to be the most active.  相似文献   

On the drivers of UK direct investment in the Spanish regions: A spatial Durbin approach     

Adolfo Maza  Paula Gutiérrez-Portilla  José Villaverde 《Growth and change》2020,51(2):646-675

This paper empirically examines the key factors driving UK direct investment in the Spanish regions over the period 2000–2016 and, consequently, tries to unveil its main motivation. Applying a spatial Durbin panel model to capture spatial linkages, the results point to the existence of complementarity between the FDI received by a region and that of the remaining ones. This outcome, along with a positive and statistically significant spillover effect of market potential, reveals that complex-vertical FDI motivation with agglomeration economies prevails among UK MNEs investing in Spain. Additionally, our findings unveil the role played by some other FDI drivers, such as wages and infrastructure. Furthermore, the paper is unique in decomposing the average direct and spillover effects by region and pairs of regions, so that remarkable differences can be identified. This breakdown has strong significance from a policy perspective since it can guide regional policy makers. In short, our findings point out to the fact that FDI policy should be jointly designed by those regions presenting strong bilateral spillover effects. Thus, greater cooperation among policy makers would be welcome.  相似文献   

Inheritance of Bacillus thuringiensis Cry2Ab2 protein resistance in Helicoverpa zea (Lepidoptera: Noctuidae)     

Fei Yang  Graham P Head  Paula A Price  Jos C Santiago Gonzlez  David L Kerns 《Pest management science》2020,76(11):3676-3684

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Strategy to identify resistance to white mould associated with high yield for irrigated common bean in Brazil     

Renan C. Lima  Pablo H. Teixeira  Ari F. F. Souza  Trazilbo J. Paula Júnior  Hudson Teixeira  Miller S. Lehner  José E. S. Carneiro  Tiago S. Marçal  Rogerio F. Vieira 《Plant pathology》2020,69(6):1172-1184

Development of common bean cultivars with partial white mould resistance through breeding techniques has been a challenge in Brazil. As yet, lines/cultivars from breeding programmes have not been investigated for resistance; therefore, this study screened 107 lines/cultivars for their reactions to white mould in 14 preliminary trials conducted under irrigation. Thirteen resistant lines/cultivars (three of Andean origin) and six Mesoamerican cultivars (three intermediately resistant and three susceptible) were selected for further investigation. These lines/cultivars and the resistant control A195 were evaluated in six advanced trials and two straw tests to assess the effectiveness of the screening procedure. In 11 preliminary trials, screenings were performed under moderate/high or higher disease pressure. These pressures occurred in two advanced trials in which, when yields were averaged across moderate/high and high pressures, 10 Mesoamerican lines/cultivars selected for resistance yielded 14%, 23%, and 38% more than intermediately resistant cultivars, A195, and susceptible cultivars, with median disease ratings (1–9 scale) of 4.5, 5.7, 5.7, and 6.7, respectively. In the straw test, three Andean lines/cultivars (A195 included) and two susceptible cultivars in the field were among those with the highest levels of physiological resistance. Thus, field rating under high disease pressure and greenhouse rating did not correlate significantly, suggesting that field trials are critical to evaluating resistance and to identifying high-yielding beans. Therefore, lines/cultivars from breeding programmes assessed in field trials may provide a low cost and fast way to identify high-yielding bean cultivars with partial resistance to white mould in the subtropical southern hemisphere.  相似文献   

Assessment of the long‐acting ivermectin formulation in sheep: Further insight into potential pharmacokinetic interactions     

Mariana Ballent  Maria Laura Mat  Paula Dominguez  Guillermo Virkel  Melanie Albrich  Anne Lespine  Carlos Lanusse  Adrian Luis Lifschitz 《Journal of veterinary pharmacology and therapeutics》2019,42(2):189-196

The aim of the current study was to evaluate the in vivo pharmacokinetic of ivermectin (IVM) after the administration of a long‐acting (LA) formulation to sheep and its impact on potential drug‐drug interactions. The work included the evaluation of the comparative plasma profiles of IVM administered at a single therapeutic dose (200 μg/kg) and as LA formulation at 630 μg/kg. Additionally, IVM was measured in different gastrointestinal tissues at 15 days posttreatment with both IVM formulations. The impact of the long‐lasting and enhanced IVM exposure on the disposition kinetics of abamectin (ABM) was also assessed. Plasma (IVM and ABM) and gastrointestinal (IVM) concentrations were analyzed by HPLC with fluorescent detection. In plasma, the calculated C_max and AUC_0‐t values of the IVM‐LA formulation were 1.47‐ and 3.35‐fold higher compared with IVM 1% formulation, respectively. The T_1/2ab and T_max collected after administration of the LA formulation were 2‐ and 3.5‐fold longer than those observed after administration of IVM 1% formulation, respectively. Significantly higher IVM concentrations were measured in the intestine mucosal tissues and luminal contents with the LA formulation, and in the liver, the increase was 7‐fold higher than conventional formulation. There was no drug interaction between IVM and ABM after the single administration of ABM at 15 days post‐administration of the IVM LA formulation. The characterization of the kinetic behavior of the LA formulation to sheep and its potential influence on drug‐drug interactions is a further contribution to the field.  相似文献   

Fitness costs of Vip3A resistance in Spodoptera frugiperda on different hosts     

Xuan Chen  Graham P Head  Paula Price  David L Kerns  Marlin E Rice  Fangneng Huang  Ryan T Gilreath  Fei Yang 《Pest management science》2019,75(4):1074-1080

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Extended evaluation of Bt protein cross‐pollination in seed blend plantings on survival,growth, and development of Helicoverpa zea feeding on refuge ears     

Fei Yang  David L Kerns  Graham P Head  Paula A Price  Ronnie Levy  Ying Niu  Fangneng Huang 《Pest management science》2020,76(3):1011-1019

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Thoughts on AVMA policy on elephant guides and tethers     

Kislak P 《Journal of the American Veterinary Medical Association》2008,233(4):550; author reply 550-550; author reply 551

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Effects of continuous positive airway pressure on respiratory function in sedated foals     

Sharanne L. Raidal  Rosemary McKean  Paula A. Ellul  Sharon G. Nielsen  Christopher T. Quinn 《Journal of Veterinary Emergency and Critical Care》2019,29(3):269-278

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Native and exotic seed dispersal by the stone marten (Martes foina): implications for the regeneration of a relict climactic forest in central Portugal     

Lúcia PEREIRA  Ana VASQUES  Paula MAIA  Maria Joo RAMOS PEREIRA  Carlos FONSECA  Milena MATOS 《Integrative zoology》2019,14(3):280-292

The stone marten (Martes foina) is a carnivorous mammal that often consumes fleshy fruits, thus potentially promoting seed dispersion. The present study was developed in Bussaco National Forest, central Portugal, and aimed to assess the potential role of the stone marten in dispersing native and exotic plants in different forest landscape types. Seeds from stone marten scats and fleshy fruits were collected monthly and were thereafter identified and sowed in a nursery, following a randomized experimental setup. Plant emergence was monitored fortnightly. Generalized linear models were used to test for differences in time and success of emergence between seeds from scats and fruits of 3 native species (Rubus ulmifolius, Arbutus unedo and Celtis australis) and 1 exotic plant species with invasive behavior (Prunus laurocerasus). Fruit consumption by the stone martens significantly increased and accelerated the germination of the native R. ulmifolius but had no effect on the other 2 native species or on the invasive species. This suggested that stone martens contribute to gene flow and forest regeneration by dispersing native plant seeds. However, although the germination was not enhanced in the invasive species, the preference of stone martens for these fruits may potentially contribute to the proliferation of P. laurocerasus. Our study represents a contribution to better understanding the fauna and flora interactions, enabling for a more conscious and effective decision‐making in forest management.  相似文献