Comparison of ultrasonographic characteristics of the thyroid gland in healthy small-, medium-, and large-breed dogs     

Brömel C  Pollard RE  Kass PH  Samii VF  Davidson AP  Nelson RW 《American journal of veterinary research》2006,67(1):70-77

OBJECTIVE: To determine ultrasonographic characteristics of the thyroid gland in healthy small-, medium-, and large-breed dogs and evaluate the relationships of thyroid gland size and volume with body weight and body surface area (BSA). ANIMALS: 72 dogs of small (6 Toy and 6 Miniature Poodles), medium (12 Beagles), and large breeds (12 Akitas and 36 Golden Retrievers). PROCEDURE: Each dog's thyroid gland was examined ultrasonographically with a 10- to 5-MHz multifrequency linear-array transducer. Size, shape, echogenicity, and homogeneity of thyroid lobes were evaluated on longitudinal and transverse images. Thyroid lobe volume was estimated by use of the equation for an ellipsoid (pi/6 [length x height x width]). RESULTS: Thyroid lobes appeared fusiform or elliptical on longitudinal images and triangular or round to oval on transverse images. In most dogs, thyroid lobes were hyperechoic or isoechoic, compared with surrounding musculature, and had a homogeneous echogenic pattern. Mean length, width, height, and volume of thyroid lobes were significantly greater in Akitas and Golden Retrievers, compared with findings in Beagles or Poodles; mean length, width, and height were significantly greater in Beagles, compared with findings in Poodles. Total thyroid gland volume correlated with body weight (r = 0.73) and BSA (r = 0.74). CONCLUSIONS AND CLINICAL RELEVANCE: Among the dog breeds examined ultrasonographically, thyroid lobe size and volume were more variable than shape, echogenicity, and homogeneity. The correlation of thyroid gland volume with BSA suggests that size of the dog, rather than breed, should be considered when assessing thyroid glands ultrasonographically.  相似文献   

What is your diagnosis? Abdominally retained testis     

Davidson EB  Reaugh HF  Bahr RJ 《Journal of the American Veterinary Medical Association》2006,228(2):203-204

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Humanization of yeast to produce complex terminally sialylated glycoproteins     

Hamilton SR  Davidson RC  Sethuraman N  Nett JH  Jiang Y  Rios S  Bobrowicz P  Stadheim TA  Li H  Choi BK  Hopkins D  Wischnewski H  Roser J  Mitchell T  Strawbridge RR  Hoopes J  Wildt S  Gerngross TU 《Science (New York, N.Y.)》2006,313(5792):1441-1443

Yeast is a widely used recombinant protein expression system. We expanded its utility by engineering the yeast Pichia pastoris to secrete human glycoproteins with fully complex terminally sialylated N-glycans. After the knockout of four genes to eliminate yeast-specific glycosylation, we introduced 14 heterologous genes, allowing us to replicate the sequential steps of human glycosylation. The reported cell lines produce complex glycoproteins with greater than 90% terminal sialylation. Finally, to demonstrate the utility of these yeast strains, functional recombinant erythropoietin was produced.  相似文献   

The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study          下载免费PDF全文

Andrew C. Simpson  Jennifer R. Schissler  Rod A.W. Rosychuk  A Russell Moore 《Veterinary dermatology》2017,28(5):485-e113

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