Effect of altering the steric hindrance of the nitrogen atom in 2,5-bis(pyridin-n-yl)-1,3,4 thiadiazole isomers on their ability to elicit tomato defense responses against Verticillium wilt and crown gall diseases     

Amal Smaili  Abdelhakim Laachir  Lalla Aicha Rifai  Tayeb Koussa  Fouad Bentiss  Salaheddine Guesmi  Mohamed Faize 《European journal of plant pathology / European Foundation for Plant Pathology》2018,151(4):1035-1048

Three isomers of the ligand 2,5-bis(pyridinyl)-1,3,4-thiadiazole, with the N atom of pyridine group in position 2, 3 or 4, named respectively, L2, L3 and L4 were compared for their use as plant defense activators. They were examined for their ability to protect tomato plants from Verticillium dahliae and Agrobacterium tumefaciens in the greenhouse, to induce reactive oxygen species and to activate plant defenses, including antioxidant enzymes. The three ligand isomers exhibited in vitro only slight inhibition of radial growth of V. dahliae, while no significant inhibition was observed for phytopathogenic bacteria. In the greenhouse, the three ligand isomers statistically reduced the severity of Verticillium wilt and crown gall on tomato plants, and the isomers L3 and L4 were the most efficient to control Verticillium wilt. This superiority was reflected in their differential ability to activate H₂O₂ accumulation, antioxidant enzymes including catalase and ascorbate peroxidase and other defense-related enzymes such as guaiacol peroxidase and polyphenol oxidase. These results demonstrated that the presence of the N atom within the two pyridinyl groups in the position 3 or 4 highly enhanced the activity of plant defense and antioxidant responses as well as their ability to reduce the severity of symptoms caused by V. dahliae on tomato.  相似文献   

Expression of preproendothelin-2 splice variant in cat     

Uchide T  Fujimori Y  Temma K  Sasaki T  Matsuu A  Fukushima U  Itoh H  Saida K 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2006,68(1):55-58

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Bifid tongue and mandibular cleft in three mule foals     

Rifai S  Bouayad H  Kay G  Knottenbelt DC  Smith M 《The Veterinary record》2006,158(3):97-98

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Evaluation of the efficacy and safety of coil occlusion for patent ductus arteriosus in dogs     

Tanaka R  Soda A  Saida Y  Sugihara K  Takashima K  Shibazaki A  Yamane Y 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(8):857-859

We performed a retrospective study of 56 dogs with Patent Ductus Arteriosus (PDA) to evaluate the indications for and efficacy of transarterial PDA coil embolization. Transarterial PDA coil embolization was conducted in 37 cases (66.1%) and surgical ligation was conducted in 16 cases (28.6%). Three cases (5.4%) were diagnosed as pulmonary hypertension and were excluded from surgical intervention. Although coil dislodgement was observed in the pulmonary artery in one case, no death occurred during coil embolization or surgical ligation. Echocardiography showed that fractional shortening decreased from 35.4 +/- 6.8% to 30.2 +/- 5.9% (P<0.05) after transarterial PDA coil embolization. Although slight residual shunts were observed in 18 cases, transarterial PDA coil embolization was effective treatment of PDA.  相似文献   

The effect of 7.2% hypertonic saline solution with 6% dextran 70 on cardiac contractility as observed by an echocardiography in normovolemic and anesthetized dogs     

Suzuki K  Otake M  Saida Y  Koie H  Asano R 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2008,70(1):89-94

We studied the effect of a small volume of 7.2% hypertonic saline solution (HSS) or HSS with 6% dextran 70 (HSD) on hemodynamic status, especially on cardiac contractility, in anesthetized dogs using the left ventricular end-systolic volume index (ESVI) and ejection fraction (EF), which can be obtained in noninvasive echocardiography. In the present study, the mean values of ESVI were unaffected by HSS and HSD infusion, whereas the left ventricular end-diastolic volume index (EDVI) was markedly and significant increased. As a result of the changes in EDVI but not in ESVI, EF increased transiently and significantly in the HSS and HSD group, whereas no such significant change was observed in the dogs that received isotonic saline solution. In addition, as a result of the increases in cardiac index but not arterial pressure, system vascular resistances (SVR) decreased transiently and significantly in the HSS and HSD groups, whereas no such significant change was observed in the ISS group. Therefore, the positive inotropic effects of HSS and HSD may be attributable to the increase in left ventricular preload and decreases in SVR rather than direct changes in myocardial contractility.  相似文献   

Surgical correction of pulmonic stenosis using transventricular pulmonic dilation valvuloplasty (Brock) in a dog     

Saida Y  Tanaka R  Hayama T  Soda A  Yamane Y 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(4):437-439

A two-month-old male long coated Chihuahua, which had symptoms including anorexia and decreased growth, was diagnosed with pulmonic valvular stenosis. Echocardiography showed the severe progression of pulmonary arterial velocity (6.29 m/s, Pressure gradient (PG); 158 mmHg). Transventricular pulmonic dilation valvuloplasty (Brock) was conducted, and stenosed valve was dilated by the oto forceps. Pleural effusion was observed postoperatively, however, it was diminished under the intensive care for five days after the surgery. The right ventricular systolic pressure was decreased to 60 mmHg in angiocardiography conducted two months postoperatively and the dog has kept a good general condition with recovered vigor and appetite.  相似文献   

Effects of Walnuts (<Emphasis Type="Italic">Juglans regia</Emphasis>) on Learning and Memory Functions     

Haider S  Batool Z  Tabassum S  Perveen T  Saleem S  Naqvi F  Javed H  Haleem DJ 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(4):335-340

Walnut has been regarded as a health food that is delicious and nutritious. Both preventive and therapeutic effects of walnut are well documented. Walnuts are rich in omega-3 fatty acids that are reported to have beneficial effects on brain function. The present work was designed to evaluate the effects of walnuts on learning and memory in male rats. The effect of oral intake of walnut was also monitored on food intake. Walnut was given orally to rats for a period of 28 days. Memory function in rats was assessed by elevated plus maze (EPM) and radial arm maze (RAM). A significant improvement in learning and memory of walnut treated rats compared to controls was observed. Walnut treated rats also exhibited a significant decrease in food intake while the change in growth rate (in terms of percentage) remained comparable between the two groups. Analysis of brain monoamines exhibited enhanced serotonergic levels in rat brain following oral intake of walnuts. The findings suggest that walnut may exert its hypophagic and nootropic actions via an enhancement of brain 5-HT metabolism.  相似文献   

Antimicrobial Activity of Untenospongin B,a Metabolite from the Marine Sponge Hippospongia communis collected from the Atlantic Coast of Morocco     

Saida Rifai  Aziz Fassouane  Anake Kijjoa  Rob Van Soest 《Marine drugs》2004,2(3):147-153

(−)-Untenospongin B isolated from the marine sponge Hippospongia communis has been tested for its antimicrobial activity against bacteria and human pathogenic fungi using agar disk method and was found to possess a broad and strong activity toward the test organisms. Its antifungal activity was further characterized by determination of the minimum inhibitory concentration (MIC) against five fungal species using broth microdilution method.  相似文献