Somatotropic axis resistance and ghrelin in critically ill foals     

R. J. I. M. Barsnick  S. D. A. Hurcombe  K. Dembek  M. L. Frazer  N. M. Slovis  W. J. A. Saville  R. E. Toribio 《Equine veterinary journal》2014,46(1):45-49

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Use of REP‐PCR and 16S rRNA gene sequencing for comparison of Mannheimia haemolytica isolates obtained from fatal cases of bovine respiratory disease in the USA and Australia     

JD Taylor  DJ Doyle  PJ Blackall  AW Confer 《Australian veterinary journal》2014,92(1-2):15-23

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Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana     

Clark RM  Schweikert G  Toomajian C  Ossowski S  Zeller G  Shinn P  Warthmann N  Hu TT  Fu G  Hinds DA  Chen H  Frazer KA  Huson DH  Schölkopf B  Nordborg M  Rätsch G  Ecker JR  Weigel D 《Science (New York, N.Y.)》2007,317(5836):338-342

The genomes of individuals from the same species vary in sequence as a result of different evolutionary processes. To examine the patterns of, and the forces shaping, sequence variation in Arabidopsis thaliana, we performed high-density array resequencing of 20 diverse strains (accessions). More than 1 million nonredundant single-nucleotide polymorphisms (SNPs) were identified at moderate false discovery rates (FDRs), and approximately 4% of the genome was identified as being highly dissimilar or deleted relative to the reference genome sequence. Patterns of polymorphism are highly nonrandom among gene families, with genes mediating interaction with the biotic environment having exceptional polymorphism levels. At the chromosomal scale, regional variation in polymorphism was readily apparent. A scan for recent selective sweeps revealed several candidate regions, including a notable example in which almost all variation was removed in a 500-kilobase window. Analyzing the polymorphisms we describe in larger sets of accessions will enable a detailed understanding of forces shaping population-wide sequence variation in A. thaliana.  相似文献   

Whole-genome patterns of common DNA variation in three human populations     

Hinds DA  Stuve LL  Nilsen GB  Halperin E  Eskin E  Ballinger DG  Frazer KA  Cox DR 《Science (New York, N.Y.)》2005,307(5712):1072-1079

Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry. Our results indicate that these SNPs capture most common genetic variation as a result of linkage disequilibrium, the correlation among common SNP alleles. We observe a strong correlation between extended regions of linkage disequilibrium and functional genomic elements. Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations.  相似文献   

Alternative eucalypts for commercial pulpwood production at moderately dry sites in the warm temperate zone of KwaZulu-Natal,South Africa     

Robin AW Gardner  Keith M Little  Arnulf Kanzler  Thimagren N Naidoo 《Southern Forests》2018,80(2):115-129

During 2001, a series of four site–taxa interaction trials was established in the warm temperate (mean annual temperature range 16–19 °C) forestry climatic zone of KwaZulu-Natal (KZN), South Africa. The main objective was to investigate the commercial forestry potential of a range of alternative Eucalyptus and Corymbia taxa for moderately dry (mean annual precipitation < 850 mm) sites within the zone. At rotation end, all trials received final standing tree measurements. At one of the sites (Rockvale), trees of eight promising alternative taxa were felled, stem measurements and wood samples taken, and wood and fibre productivities determined. On the basis of tree growth and wood and fibre production, C. citriodora subsp. variegata, C. henryi, E. badjensis, E. benthamii and E. dorrigoensis (listed alphabetically) demonstrated the greatest potential as commercial alternatives for moderately dry sites in the KZN warm temperate zone. The majority of these taxa showed strong site specificity. Eucalyptus benthamii was the only taxon showing high growth adaptability to the entire range of site conditions applied in the series. The non-susceptibility of C. citriodora subsp. variegata and C. henryi to the current topical insect pests Thaumastocoris peregrinus, Leptocybe invasa and Glycaspis brimblecombei elevates the appeal of these taxa as potential alternative planting choices for moderately dry sites within lower altitude (<1 100 m asl) areas of the climate zone. The matching of the most promising alternative taxa in the series to the range of sites encountered in moderately dry areas of the KZN warm temperate forestry zone is discussed in this paper.  相似文献