Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial,Antidiabetic, Antifungal,Anti-Inflammatory,Antiprotozoal, Antituberculosis,and Antiviral Activities; Affecting the Immune and Nervous Systems,and other Miscellaneous Mechanisms of Action ?     

Alejandro M. S. Mayer  Abimael D. Rodríguez  Orazio Taglialatela-Scafati  Nobuhiro Fusetani 《Marine drugs》2013,11(7):2510-2573

The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral pharmacological activities were reported for 102 marine natural products. Additionally, 60 marine compounds were observed to affect the immune and nervous system as well as possess antidiabetic and anti-inflammatory effects. Finally, 68 marine metabolites were shown to interact with a variety of receptors and molecular targets, and thus will probably contribute to multiple pharmacological classes upon further mechanism of action studies. Marine pharmacology during 2009–2011 remained a global enterprise, with researchers from 35 countries, and the United States, contributing to the preclinical pharmacology of 262 marine compounds which are part of the preclinical pharmaceutical pipeline. Continued pharmacological research with marine natural products will contribute to enhance the marine pharmaceutical clinical pipeline, which in 2013 consisted of 17 marine natural products, analogs or derivatives targeting a limited number of disease categories.  相似文献   

Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)     

Tatiana da Rosa Guimar?es  Carlos Guillermo Quiroz  Caroline Rigotto  Simone Quintana de Oliveira  Maria Tereza Rojo de Almeida  éverson Miguel Bianco  Maria Izabel Goulart Moritz  Jo?o Luís Carraro  Jorge Alejandro Palermo  Gabriela Cabrera  Eloir Paulo Schenkel  Flávio Henrique Reginatto  Cláudia Maria Oliveira Sim?es 《Marine drugs》2013,11(11):4176-4192

The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. The TSH fraction was the most effective against HSV-1 replication (SI = 15.33), whereas compounds 1 (SI = 2.46) and 2 (SI = 1.95) were less active. The most active fraction and these compounds were also assayed to determine the viral multiplication step(s) upon which they act as well as their potential synergistic effects. The anti-HSV-1 activity detected was mediated by the inhibition of virus attachment and by the penetration into Vero cells, the virucidal effect on virus particles, and by the impairment in levels of ICP27 and gD proteins of HSV-1. In summary, these results suggest that the anti-HSV-1 activity of TSH fraction detected is possibly related to the synergic effects of compounds 1 and 2.  相似文献   

Post‐grazing cutting management in tall fescue affects the sward structure,forage and liveweight production     

Jorge Omar Scheneiter  Jonatan Nicols Camarasa  Daniel Aperlo  Martín Alejandro Ferrari  Martín Nalino  María J. Beribe 《Grass and Forage Science》2019,74(4):661-669

Tall fescue is the main perennial grass of the pastures of the temperate region of Argentina. However, after flowering in spring, tall fescue loses productivity and quality. Based on this, the objective of this work was to evaluate the effects of different post‐grazing mechanical cutting managements on the forage mass, leaf proportion, stocking rate, liveweight gain and liveweight production of tall fescue pastures. The treatments were post‐grazing mechanical cutting at anthesis (FC), post‐grazing mechanical cutting throughout spring and summer (SSC), and no post‐grazing mechanical cutting (NC). The experiment was performed from 2011 to 2014 in Argentina. The greatest and lowest forage mass were determined in September–November and May–September respectively. The leaf proportion of the SSC treatment was greater than that of the NC treatment, except in September–November. NC had higher stocking rate and lower liveweight gain than SSC, and neither NC nor SSC differed from FC. The liveweight production of the treatments was characterized by a trade‐off between stocking rate and liveweight gain. We conclude that FC is an attractive management because, with a single post‐grazing cutting, swards remain productive and leafy.  相似文献   

Behavioural response of a trophic specialist, the Iberian lynx, to supplementary food: Patterns of food use and implications for conservation     

José V. López-Bao  Alejandro Rodríguez  Francisco Palomares 《Biological conservation》2008,141(7):1857-1867

Prey scarcity compromises population survival, especially for specialist predators. Supplementary feeding is a management tool that can be applied to reverse the decline of food-limited populations. We analyse how a population of Iberian lynx, a threatened food specialist, initially reacted to, and subsequently used, supplementary food. Twenty-seven feeding stations (FS) with domestic rabbits were placed in the Doñana Biological Reserve, SW Spain, between 2002 and 2005. We recorded lynx tracks inside and around stations to analyse spatio-temporal patterns of use, as well as the performance of several station designs. Iberian lynx used 62% of the FS installed, and consumed most of the supplied food. All station designs were used and food provision apparently covered the energetic needs of the lynx inhabiting the reserve. There was spatial aggregation in the use of the FS. Fourteen weeks were needed on average for lynx to become familiar with feeding stations and making a regular use of the supplementary food. Seasonal variations in consumption frequency appeared to be modulated by fluctuations of wild rabbit numbers throughout its annual cycle as well as by variation in energy demand of breeding females. The Iberian lynx responded positively to our supplementary feeding programme. We show that this technique allows the persistence of lynx populations during long periods in areas where wild rabbits are extremely scarce. Supplementary food may be used to sustain lynx whenever rabbit populations need recovery, as well as in the context of lynx restocking or reintroduction programmes.  相似文献   

Abomasal infusion of casein, starch and soybean oil differentially affect plasma concentrations of gut peptides and feed intake in lactating dairy cows     

Relling AE  Reynolds CK 《Domestic animal endocrinology》2008,35(1):35-45

The effects of specific nutrients on secretion and plasma concentrations of gut peptides (glucagon-like peptide-1((7-36)) amide (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and cholecystokinin-8 (CCK)) differ across species, but are not reported for cattle. Our objective was to determine acute (hours) and chronic (1 week) effects of increased abomasal supply of protein, carbohydrate, or fat to the small intestine on dry matter intake (DMI) and plasma concentrations of GLP-1, GIP, CCK, and insulin. Four mid-lactation Holstein cows were used in a 4 x 4 Latin square design experiment. Treatments were 7-day abomasal infusions of water, soybean oil (500 g/d), corn starch (1100 g/d), or casein (800 g/d). Jugular vein plasma was obtained over 7h at the end of the first and last day of infusions. Oil infusion decreased DMI on day 7, but total metabolizable energy (ME) supply (diet plus infusate) did not differ from water infusion. Casein and starch infusion had no effect on feed DMI; thus, ME supply increased. Decreased DMI on day 7 of oil infusion was accompanied by increased plasma GLP-1 concentration, but decreased plasma CCK concentration. Increased plasma GIP concentration was associated with increased ME supply on day 7 of casein and starch infusion. Casein infusion tended to increase plasma CCK concentration on both days of sampling, and increased plasma GLP-1 and insulin concentration on day 1 of infusion. The present data indicate a sustained elevation of plasma concentration of GLP-1, but not CCK, may contribute to the reduced DMI observed in dairy cows provided supplemental fat.  相似文献   

Pharmacokinetics of meloxicam after oral administration of a granule formulation to healthy horses     

Francisco Javier Mendoza  Juan Manuel Serrano‐Rodriguez  Alejandro Perez‐Ecija 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):961-967

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Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs with chronic inflammatory enteropathy     

Sara A. Wennogle  Simon L. Priestnall  Alejandro Surez‐Bonnet  Sirikul Soontararak  Craig B. Webb 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(4):1669-1676

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Seasonality in Saint Croix male lamb reproductive development in northern Mexico     

Fernando Snchez‐Dvila  Rodolfo Ungerfeld  Alejandro Sergio del Bosque‐Gonzlez  Hugo Bernal‐Barragn 《Reproduction in domestic animals》2019,54(2):391-400

The aim of this study was to determine the influence of the season of birth on the body weight, testicular size, testosterone concentrations, semen output and sexual behaviour in Saint Croix male lambs. Thirty‐three lambs were born in spring (n = 10), summer (Sum; n = 12) or autumn (n = 11). Body weight and the scrotal circumference were weekly recorded; semen was also weekly collected by electroejaculation; and sexual behaviour towards oestrous ewes was weekly evaluated. Data were recorded from 15 to 33 weeks of age. The reproductive development of Saint Croix male lambs differed according to the period in which they were born. More lambs born in spring than in summer and autumn achieved puberty during this study and were also more precocious in semen production and displayed sexual behaviour earlier. Lambs born in summer delayed their semen production; however, season‐related negative effects were less pronounced at the end of the study than in autumn born lambs born. In conclusion, despite the apparently low seasonality of the breed, Saint Croix male lambs showed in this study a seasonal pattern in their reproductive development at least until they achieve the puberty.  相似文献   

P. A. Thomas and J. Packham: Ecology of Woodlands and Forests: Description, Dynamics, and Diversity     

Alejandro A. Royo 《Landscape Ecology》2008,23(6):755-756

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Assessing Knowledge Production for Agrosilvopastoral Systems in South America     

Rosina Soler  Pablo Luis Peri  Héctor Bahamonde  Verónica Gargaglione  Sebastián Ormaechea  Alejandro Huertas Herrera  Laura Sánchez Jardón  Cristian Lorenzo  Guillermo Martínez Pastur 《Strength and Conditioning Journal》2018,71(5):637-645

In recent decades agroforestry has undergone significant development in Latin America. South America generates the most scientific research on the topic in the region. We conducted a comprehensive review and analysis of knowledge production for South American agroforestry that includes livestock grazing, known as agrosilvopastoralism (AS), examining how different sociopolitical factors such as sources of funding, institutional priorities, and international cooperation can bias the direction and objectives of scientific research. We assessed the major attributes of scientific publications on the topic (25 articles per country; overall n = 210) and the potential factors underlying the processes of research and development in the region. The tree component was the most studied, while the livestock component received less attention. Studies were mainly focused on the production of goods and services (monetary or nonmonetary approaches), except in Brazil, where conservation was the major study objective. Stakeholders were involved in more than half of the studies (60%), and they were mostly ranchers and local producers. More than half (70%) of the studies offered recommendations based on their results, and such recommendations were mostly concerned with the management of agrosilvopastoral system components. In general, studies were led just as often by local as foreign first authors and coauthored by more than three people as part of interinstitutional working groups. Brazil, Argentina, Colombia, and Chile had more frequent cooperation among institutions and countries but mainly used their own funding. In contrast, Bolivia, Ecuador, and Peru had almost 100% of their studies supported by foreign countries (North America and Europe). Countries with greater internal funding of research generated more long-term studies. Besides this, two clear trends were detected: 1) conservation and social aspects were mainly supported by sources from external countries led by foreign principal investigators, and 2) production issues were supported from sources within countries and supported high levels of cooperation among institutions.  相似文献