The thermal antinociceptive effects of a high-concentration formulation of buprenorphine alone or followed by hydromorphone in conscious cats     

Kara L. Moreno  Elizabeth M. Scallan  Beatriz P. Monteiro  Paulo V. Steagall  Bradley T. Simon 《Veterinary anaesthesia and analgesia》2021,48(4):570-576

ObjectiveTo evaluate the thermal antinociceptive effects of a high-concentration formulation of buprenorphine alone or followed by hydromorphone in conscious cats.Study designRandomized, blinded, placebo-controlled crossover study design.AnimalsA total of six purpose-bred, adult female ovariohysterectomized Domestic Short Hair cats.MethodsCats were allocated into three treatments each consisting of two injections, subcutaneous then intravenous (IV) administration, 2 hours apart: treatment SS, two injections of 0.9% saline; treatment BS, buprenorphine (0.24 mg kg^–1, 1.8 mg mL^–1) and saline; and treatment BH, buprenorphine (0.24 mg kg^–1) and hydromorphone (0.1 mg kg^–1). Skin temperature (ST) and thermal threshold (TT) were recorded before (baseline) and for 24 hours following first injection. TT data were analyzed using mixed linear models and a Benjamini–Hochberg sequential adjustment procedure (p < 0.05).ResultsThere were no significant differences among treatments for baseline ST and TT values, treatment SS over time and between treatments BS and BH. Compared with baseline, TT was significantly increased at all time points in treatments BH and BS except at 2 hours in treatment BS. TT was significantly higher than SS at 3–18 hours and 4–12 hours for treatments BS and BH, respectively. Maximal increases in TT were 47.5 °C at 2 hours, 53.9 °C at 3 hours and 52.4 °C at 6 hours in treatments SS, BS and BH, respectively.Conclusions and clinical relevanceAdministration of IV hydromorphone following high-concentration buprenorphine provided no additional antinociception and decreased the duration of effect when compared with high-concentration buprenorphine alone. Alternative analgesics should be considered if additional analgesia is required after administration of high-concentration buprenorphine.  相似文献   

The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs     

Alex M. Lynch  Laura K. Ruterbories  Emily Griffith  Rita M. Hanel  Alyssa P. Stablein  Marjory B. Brooks 《Journal of Veterinary Emergency and Critical Care》2021,31(1):59-65

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‘Star Ruby’ grapefruit and ‘Clemenules’ mandarin trees show different physiological and agronomic responses to irrigation with saline water     

J. G. Pérez-Pérez  F. García-Sánchez  J. M. Robles  P. Botía 《Irrigation Science》2015,33(3):191-204

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Describing Human–Wildlife Interaction from a European Perspective     

Maria Johansson  Sabrina Dressel  Emma Kvastegård  Göran Ericsson  Anke Fischer  Bjørn P. Kaltenborn 《Human Dimensions of Wildlife》2016,21(2):158-168

European researchers from both the natural and social sciences show growing interest in studying interactions between society and wildlife. A wealth of theoretical frameworks, concepts, and methods are used, but an integration of perspectives is lacking. This research note summarizes results from two workshops that included 63 delegates from 25 European countries, as well as a follow-up survey of 41 respondents. Two main theoretical approaches to the study of human–wildlife interactions were identified. One approach focuses on the collective societal level relying on theories of governance, social representation, deliberative procedures, and commons theory. The other approach targets individuals or groups, and is based on theories such as the cognitive hierarchy, theory of reasoned action, and theory of planned behavior. Interdisciplinary collaboration is needed to identify the best options for wildlife conservation and management in a more politically integrated Europe.  相似文献   

A SURVEY OF RADIOLOGISTS AND REFERRING VETERINARIANS REGARDING IMAGING REPORTS          下载免费PDF全文

Andrea Weissman  Mauricio Solano  Olivier Taeymans  Shannon P. Holmes  David Jiménez  Bruce Barton 《Veterinary radiology & ultrasound》2016,57(2):124-129

An imaging report is a vital communication tool between a radiologist and clinician. In a field where in‐person communication may not be readily available, it is imperative that the report clearly relays pertinent clinical information in a timely manner. The purpose of this observational study was to describe and compare opinions and expectations of small animal general practitioners, veterinary specialists, and veterinary radiologists regarding the imaging report. Online surveys were distributed, and data were collected from 202 veterinary clinicians and 123 veterinary radiologists. The majority (89%) of clinicians were satisfied with their imaging reports and stated that they read the radiology report as soon as it was available (92%). Just less than half (48%) of clinicians indicated it was standard of care that a board‐certified veterinary radiologist read all imaging studies. Radiologists and clinicians agreed that a clinical history (98% and 94%, respectively) and clinical question (82% and 68%, respectively) were needed to generate a good radiology report. Fifty‐five percent to 70% of clinicians prefer red bulleted reports, which included incidental findings (96%); while radiologists slightly favored prose reporting (37–46%). Clinicians found it helpful when additional imaging (86%), medical (71%), and surgical recommendations (73%) were made. About one‐third of specialists who had been in practice for >11 years thought they were better able to interpret imaging for their own specialty than the radiologist. Clinicians voiced discontentment with reports that were not completed in a timely manner or did not give a prioritized differential list. Further studies are warranted to provide a more in‐depth evaluation of veterinary radiology reporting structure and style.  相似文献   

Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis          下载免费PDF全文

Beatriz P Monteiro  Mary P Klinck  Maxim Moreau  Martin Guillot  Paulo VM Steagall  Daniel K Edge  Jean‐Pierre Pelletier  Johanne Martel‐Pelletier  Dominique Gauvin  Jérôme RE del Castillo  Eric Troncy 《Veterinary anaesthesia and analgesia》2016,43(6):643-651

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Use of an epidural catheter inserted at L1–L2 in a dog undergoing pelvic limb amputation          下载免费PDF全文

Mathieu Raillard  Thomas R Harcourt‐Brown  Ivan P Doran  Paul D MacFarlane 《Veterinary anaesthesia and analgesia》2016,43(2):237-238

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The 5‐lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines          下载免费PDF全文

J. P. Loftus  D. Cavatorta  J. J. Bushey  C. B. Levine  C. S. Sevier  J. J. Wakshlag 《Veterinary and comparative oncology》2016,14(2):e17-e30

The 5‐lipoxygenase (5‐LOX) inhibitor tepoxalin has been shown to slow canine osteosarcoma (OSA) tumour xenografts growth, yet the mechanisms are poorly elucidated. Further examination of tepoxalin in canine OSA cell lines shows that tepoxalin treated cells undergo apoptosis through caspase‐3 activation and annexin staining. Interestingly, apoptosis is superseded by an increase in reactive oxygen species (ROS), as measured by activation of dihydrorhodamine 123 and mitosox. This increase in ROS appears to be related to the 5‐LOX inhibitor regardless of cellular 5‐LOX status, and was not observed after treatment with the tepoxalin metabolite RWJ20142. Additionally, 5‐LOX inhibition by tepoxalin appears to increase phosphatase and tensin (PTEN) homolog activity by preventing its alkylation or oxidation. PTEN modification or inhibition allows phosphoinositide‐3 (PI3) kinase activity thereby heightening activation of protein kinase B (AKT) phosphorylation. Our data suggest that off target oxidation and LOX inhibition play roles in the apoptotic response.  相似文献   

Of mice and men: olfactory neuroblastoma among animals and humans          下载免费PDF全文

A. Lubojemska  M. Borejko  P. Czapiewski  R. Dziadziuszko  W. Biernat 《Veterinary and comparative oncology》2016,14(3):e70-e82

Olfactory neuroblastoma (ONB) is a rare tumour of nasal cavity and paranasal sinuses that arises from the olfactory neuroepithelium and has unpredictable clinical course. As the sense of smell is phylogenetically one of the first senses and olfactory neuroepithelium is evolutionary conserved with striking similarities among different species, we performed an extensive analysis of the literature in order to evaluate the similarities and differences between animals and humans on the clinical, morphological, immunohistochemical, ultrastructural and molecular level. Our analysis revealed that ONB was reported mainly in mammals and showed striking similarities to human ONB. These observations provide rationale for introduction of therapy modalities used in humans into the veterinary medicine. Animal models of neuroblastoma should be considered for the preclinical studies evaluating novel therapies for ONB.  相似文献   

Plasma biomarkers profile of female dogs with mammary carcinoma and its association with clinical and pathological features          下载免费PDF全文

R. P. Soares  L. G. R. Ribeiro  K. A. Damasceno  A. T. Costa  A. Teixeira‐Carvalho  O. A. Martins‐Filho  G. D. Cassali 《Veterinary and comparative oncology》2016,14(1):88-100

The immunological biomarkers profiles were evaluated using Luminex as putative measures to monitor canine mammary carcinomas (MCs). Forty female dogs were categorized into benign mixed tumour (MC‐BMT = 28) and mammary carcinoma (MC=12). The ascendant biomarker signatures were used to compare the groups. For example, a higher frequency of MC‐BMT animals producing IL‐6, CXCL‐8 and CXCL‐10 was observed, whereas for the MC group IL‐2 and CXCL‐8 were detected. MC‐BMT animals without metastasis had an increase in the levels of IL‐2, CXCL‐8, CXCL‐10, IL‐6, TNF‐α, IL‐15 and a decrease in IL‐10 and CXCL‐8. MC‐BMT animals with metastasis showed only an increase in CXCL‐10 and a decrease in IL‐18. After comparing the ascendant signatures following the presence of metastasis in both groups, a higher frequency of dogs exhibiting IL‐10 production was observed. Pearson correlation (P = 0.0273) and receiver operating characteristic (ROC) curve analysis revealed that this pattern was associated with worse outcome and lower survival rates in MC animals.  相似文献