A clinical comparison of remifentanil or alfentanil in propofol-anesthetized cats undergoing ovariohysterectomy     

Padilha ST  Steagall PV  Monteiro BP  Kahvegian MA  Ubukata R  Rodrigues EO  Rosa AL  Aguiar AJ 《Journal of Feline Medicine and Surgery》2011,13(10):738-743

Sixteen cats were used to compare the cardiovascular and anesthetic effects of remifentanil (REMI) or alfentanil (ALF) in propofol-anesthetized cats undergoing ovariohysterectomy. After premedication with acepromazine, anesthesia was induced and maintained with a constant rate infusion of propofol (0.3 mg/kg/min). REMI or ALF infusions were administered simultaneously with propofol. Heart rate (HR), systolic arterial pressure (SAP), pulse oximetry (SpO(2)), rectal temperature (RT), and response to surgical stimulation were recorded at predefined time points during anesthesia. Data [mean±standard deviation (SD)] were analyzed by analysis of variance (ANOVA) for repeated measures followed by a Dunnett's test and Student t-test (P<0.05). SAP was significantly lower in ALF group than in REMI group. Extubation time was significantly shorter in REMI than in ALF group. Overall infusion rate of REMI and ALF was 0.24±0.05 μg/kg/min and 0.97±0.22 μg/kg/min, respectively. The combination of propofol and REMI or ALF provided satisfactory anesthesia in cats undergoing ovariohysterectomy.  相似文献   

Geographical distribution of Alzheimer's disease cases at birth and the geochemical profile of Saguenay-Lac-Saint-Jean/Québec,Canada (image project)     

Jean François Emard  Pierre Andre  Jean -Pierre Thouez  Jean Mathieu  Camil Boily  Michel Beaudry  Andree Cholette  Yves Robitaille  Remi Bouchard  Nicolas Daoud  Francine Veilleux  Denis Gauvreau 《Water, air, and soil pollution》1994,72(1-4):251-264

Accepting as founded the hypothesis of a multifactorial origin for the Alzheimer's disease (AD), we explore the possible links between the geographical distribution of AD cases according to their birth place and the geochemical profile of the Saguenay-Lac-Saint-Jean (SLSJ) territory in the province of Québec. The method used for factor analysis of correspondances (FAC) and another one based on the differences between the residential and municipal geochemical concentrations (DRMC) have been used for this purpose. The geochemical matrix of SLSJ relates the highest concentrations of nickel, copper and zinc to the sector surrounding the Jonquière municipality. Moreover, high concentrations of iron, lead and manganese were found in the northern sector of the Lac Saint-Jean. The DRMC method corroborates this strong correlation between iron, lead and manganese. Furthermore, these concentrations do not differ from the north-american geochemical standards. No single geochemical element seems to be associate with the spatial distribution of cases. It is, however, still possible that a certain synergistic effect between two or several elements could be implied in the development of the disease. According to the results of the soil analysis, there does not seem to be any association between the spatial distribution of cases and the concentration of aluminum, a chemical element that has been thought to be implied in the etiology of AD. These results are compared with those obtained by other workers in the micronesian islands, where abnormally high frequencies of amyotrophic lateral sclerosis and parkinsonism dementia have already been observed.  相似文献   

Effects of aerosolized albuterol on physiologic responses to exercise in standardbreds.     

M R Mazan  A M Hoffman 《American journal of veterinary research》2001,62(11):1812-1817

OBJECTIVE: To examine the effects of an aerosolized beta2-adrenoreceptor agonist, albuterol, on performance during a standardized incremental exercise test in clinically normal horses. ANIMALS: 8 Standardbred pacing mares. PROCEDURE: Clinically normal horses, as judged by use of physical examination, hematologic findings, serum biochemical analysis, and airway endoscopy, were randomly assigned to 2 groups and were given 900 microg of albuterol via a metered-dose inhaler 30 minutes before beginning a standardized incremental exercise test in a crossover design with a 7-day minimum washout. Further examination included measurement of baseline lung mechanics, response to histamine bronchoprovocation, and bronchoalveolar lavage. RESULTS: No significant differences (albuterol vs placebo) were seen for any incremental exercise test variables (ie, maximum oxygen consumption, maximum carbon dioxide consumption, respiratory quotient, treadmill speed at heart rate of 200 beats/min, or number of steps completed during an incremental exercise protocol). Mast cell percentage was significantly (r = -0.84) associated with the concentration of aerosolized histamine that evoked a 100% increase in total respiratory system resistance. No other direct correlations between bronchoalveolar lavage fluid cell types and any indices of exercise capacity or airway reactivity were found. CONCLUSIONS AND CLINICAL RELEVANCE: Although no horse had exercise intolerance, 4 horses had airway hyperreactivity with bronchoalveolar lavage fluid mastocytosis; these horses may have been subclinically affected with inflammatory airway disease. In our study, albuterol did not enhance performance in 8 clinically normal racing-fit Standardbreds.  相似文献   

Neospora-like protozoan infection as a major cause of abortion in California dairy cattle   总被引：17，自引：0，他引：17  

M L Anderson  P C Blanchard  B C Barr  J P Dubey  R L Hoffman  P A Conrad 《Journal of the American Veterinary Medical Association》1991,198(2):241-244

Ninety-five aborted bovine fetuses received from California dairies over a 4.5-year period had histologic lesions of focal encephalitis. Protozoa that reacted with Neospora caninum antiserum were detected in the brain of 88 of these fetuses and in the heart of 1 fetus. Sarcocystis spp schizonts were seen in the vascular endothelium of 1 fetus. It was concluded that a Neospora-like cyst-forming coccidian may be a major cause of abortion in California dairy cattle.  相似文献   

Field evaluation of a commercial M-protein vaccine against Streptococcus equi infection in foals   总被引：8，自引：0，他引：8  

A M Hoffman  H R Staempfli  J F Prescott  L Viel 《American journal of veterinary research》1991,52(4):589-592

A double-blind randomized clinical trial was undertaken to determine the value of parenterally administered Streptococcus equi M-protein vaccine in foals during an epizootic of strangles. Weaned mixed-breed foals (n = 664) housed on 2 adjacent feed-lots (A and B) arrived over a 5-day period, 2 weeks before primary vaccination. Foals in lot B (n = 114) were randomly administered vaccine (n = 59) or saline solution (placebo; n = 55) on 3 occasions at biweekly intervals. Foals in lot A (n = 450) were given 1 dose of vaccine (n = 225) or placebo. The following clinical observations were scored blindly by a single observer for all foals in lot B and for 120 (randomly sampled) foals in lot A on a single day, 2 (Lot B) and 6 (lot A) weeks after final vaccination: cervical lymphadenopathy, type of bilateral nasal discharge, and palpable swelling at injection site(s). Bacteriologic culture of nasal swab specimens or lymph node aspirates from selected foals with clinical disease yielded S equi. Cervical lymphadenopathy was observed in 17 of 59 (29%) vaccinates and 39 of 55 (71%) nonvaccinated controls in lot B and in 32 of 60 (53%) vaccinates and 29 of 60 (48%) controls in lot A. Contingency chi 2 analysis confirmed significantly lower cervical lymphadenopathy rate (chi 2 = 18.5; P less than 0.001) and prevalence of mucopurulent nasal discharge (chi 2 = 11.4; P less than 0.01) for vaccinates in lot B only. Swelling(s) at the vaccine injection site were palpated in 44% of lot B and 29% of lot A vaccinates vs less than 2% of placebo controls.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Leaching requirement for salinity control III. Barley,cowpea, and celery     

G.J Hoffman  J.A Jobes 《Agricultural Water Management》1983,6(1):1-14

Leaching requirement, the smallest steady-state leaching fraction which prevents any loss in crop yield, was determined for barley, cowpea, and celery in field plots at the U.S. Salinity Laboratory. Six replicated leaching-fraction treatments were irrigated many times each day with small quantities of water having an electrical conductivity of 2.3 dS/m. The crops were grown in succession between January 1979 and September 1981.The leaching requirement (L_r) was 0.10 for barley grain and 0.13 for barley forage. For cowpea seed, L_r was 0.16; 0.17 for cowpea forage. L_r for celery was 0.14. These experimentally determined values for barley and cowpea seed are higher by about 0.05 than those predicted by a leaching-requirement model based on an exponential crop water-uptake pattern. The experimental values for celery and cowpea forage are lower than predicted values by 0.06. These differences are not considered significant, however, when considered in terms of the small differences in water applications (about 25 mm) to cause these changes in L_r. Evapotranspiration during each crop's growing season coincident with L_r was 410, 630, and 460 mm for barley, cowpea, and celery, respectively.  相似文献   

Daytime management of the mare: 1: Pre-foaling mammary secretions testing     

W.B. Ley DVM.  MS  J.L. Hoffman  T.N. Meacham Ph.D  T.L. Sullivan  R.L. Kiracofe  M.L. Wilson 《Journal of Equine Veterinary Science》1989,9(2)

Fifty-six mares of lighthorse breeding were utilized in a controlled management scheme for induced daytime foaling. All mares had pre-foaling mammary secretions sampled for evaluation of water hardness (ppm) or calcium carbonate content (ppm). Sampling began 10 days prior to expected foaling date for each mare and was performed once daily for 3 days followed by twice daily until foaling occurred. Samples were diluted 1:6 in distilled water and tested by each of 3 methods: Sofchek™ Test Strips⁴, Predict-A-Foal™ Test Kit⁵ and Titrets™ Calcium Hardness Test Kit⁶. Mares were then either induced (i) to foal (no.= 33) according to a decision point of readiness for birth as indicated by pre-foaling mammary secretion testing (≥250 ppm water hardness by Sofchek™ test, ≥ 250 ppm calcium carbonate content by Titrets test, ≥ 4 color bar changes by Predict-A-Foal test), or allowed to foal spontaneously (s) (no.=23). There were no differences (p>0.05) in the mean pre-foaling mammary secretion test values (μ_i=293ppm, μ_s=329ppm; μ_i=4.1, μ_s=4.2; and μ_i=281ppm, μ_s=298ppm; for Sofchek, Predict-A-Foal and Titrets, respectively) between mare groups at the time of foaling (time=0) for any of the 3 testing methods employed. Mean intervals to foaling after reaching decision points of readiness for birth were different (p<0.05) between Sofchek and Titrets test for both mare groups, but only in the induced-to-foal group between Sofchek and Predict-A-Foal tests. Probabilities of 79%, 53% and 59% were calculated for mares foaling spontaneously within 24 hours of reaching the decision points used in this trial of readiness for birth on the initial occasion for Sofchek, Predict-A-Foal and Titrets™ tests, respectively. Each test was determined to have the ability to predict readiness of approaching parturition and found to be easily applicable to field use. The Titrets test was found to be least variable in its response to measurement of pre-foaling mammary secretion hardness changes both within and between mares.  相似文献   

Dichlorophenobarbital-induced centrilobular hypertrophy of hepatocytes and enzyme induction in the rat.     

N V Owen  W J Griffing  D G Hoffman  W R Gibson  G F Kiplinger 《Veterinary pathology》1975,12(1):67-68

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Idioventricular tachycardia in a horse     

P J Miller  R J Rose  K Hoffman  G I Taylor 《Australian veterinary journal》1987,64(2):55-57

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DEATHS OF RUMINATS GRAZING PHALARIS TUBEROSA IN AUSTRALIA     

C. H. Gallagher  D.V.Sc.  Ph.D.  J. H. Koch  M.D.† H. Hoffman  M.Sc.  Ph.D. 《Australian veterinary journal》1967,43(11):495-500

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