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Bass GD  Blumenthal PD  Corfman P  Darney PD  Gonsalves G  Levin AA  Trussell J  Shields WC 《Science (New York, N.Y.)》2003,299(5611):1313

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Mutagenicity of trimethylphosphate in mice   总被引：4，自引：0，他引：4  

S S Epstein  W Bass  E Arnold  Y Bishop 《Science (New York, N.Y.)》1970,168(931):584-586

Subtoxic concentrations of trimethyphosphate, administered orally or parenterally to male mice, produced mutagenic effects, dependent on dosage, in the dominant lethal assay.  相似文献   

Birth of a Live Foal after Transabdominal Ultrasound-guided Cardiac Injection of a 200-day Equine Twin Fetus     

Luke Bass  Julie Wilkins  DVM 《Journal of Equine Veterinary Science》2014

In horses, development of twins is often problematic and may represent a potential life-threatening condition for the mare and both of the embryos/fetuses. There have been many attempts at various stages of gestation to reduce twin fetuses to a singleton with variable success. Techniques have been described to perform transabdominal ultrasound-guided cardiac injection of a toxic substance into a twin fetus. The case discussed in this report is of a mare that presented at 200 days with twin fetuses. Procaine penicillin was injected directly into the heart of one fetus, using an ultrasound-guided approach. The ultimate outcome was birth of a live healthy filly, followed by the passage of a mummified fetus. This report is the first to describe the procedure in a mare at more than 168 days of gestation, leading to birth of a live foal that lived longer than 3 days.  相似文献   

Flupyradifurone resistance in Myzus persicae populations from peach and tobacco in Greece     

Fillothei Papadimitriou  Maria Folia  Aris Ilias  Polyxeni Papapetrou  Emmanouil Roditakis  Chris Bass  John Vontas  John T Margaritopoulos 《Pest management science》2022,78(1):304-312

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Comparison of post-operative inflammatory response in horses undergoing elective castration treated preoperatively with ceftiofur crystalline free acid or procaine penicillin G     

T. Bergstrom  M. Frey  S. Rao  L. Bass 《Equine Veterinary Education》2022,34(8):409-416

Castration is among the most common surgical procedures performed in the horse (Equus Caballus) and a variety of post-operative complications can occur. This study aims to determine if a single dose of long-acting ceftiofur crystalline free acid (CCFA) used as a preoperative antimicrobial in equine field castrations offers any reduction in post-operative inflammatory markers when compared to procaine penicillin G (PPG). Sixty-five horses aged 8 months to 2 years were randomly assigned to the CCFA (n = 33) or PPG (n = 32) treatment groups. Horses were castrated under general anaesthesia using a closed castration technique with removal of the median raphe. Quantitative and qualitative inflammatory markers were measured and short-term complications were recorded post-operatively on Days 3, 8 and 14. No clinically significant difference in any post-operative inflammatory markers between the CCFA and PPG group was detected. In the CCFA group, 48% of horses experienced short-term post-operative complications compared to 31% in the PPG group. Regardless of the preoperative treatment, castration induced significant elevation in serum amyloid A (P<0.0001), preputial oedema (P<0.0001) and scrotal oedema (P<0.0001) at Day 3. These values returned to baseline levels by Day 8. Horses with grade 3 or above preputial oedema had elevated serum amyloid A values (P<0.001). The data from this study indicate CCFA used as a preoperative antibiotic for routine castration offers no advantages over PPG. The difference in complication rate between groups is likely of minimal clinical importance, as all complications were mild and self-limiting.  相似文献   

Effect of intracerebroventricular injection of IGF-I on circulating growth hormone concentrations in the sheep   总被引：1，自引：1，他引：0  

G S Spencer  J J Bass  S C Hodgkinson  W H Edgley  L G Moore 《Domestic animal endocrinology》1991,8(1):155-160

The effect of intracerebroventricular administration of IGF-1 on circulating growth hormone (GH) concentrations has been studied in sheep. Twenty sheep were fitted with jugular vein catheters and with indwelling cerebroventricular cannulae. IGF-I was injected into a lateral cerebral ventricle and changes in the circulating concentrations of GH were measured in jugular vein blood samples. Administration of saline had no effect on circulating GH concentrations over a 3-hr period, and administration of IGF-I (at 1, 3 and 10 micrograms/sheep) also had no significant effect on circulating GH concentrations. From these data we surmise that centrally administered IGF-I does not influence GH secretion and it seems probable that cerebrospinal fluid concentrations of IGF-I do not have a role in regulating GH release in sheep.  相似文献   

Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae)     

Bass C  Schroeder I  Turberg A  Field LM  Williamson MS 《Pest management science》2004,60(12):1157-1162

In many insect species, resistance to cyclodiene insecticides is caused by amino acid substitutions at a single residue (A302) within the M2 transmembrane region of the gamma-aminobutyric acid (GABA) receptor sub-unit termed Rdl (resistance to dieldrin). These mutations (A302S and A302G) have also been shown to confer varying levels of cross-resistance to fipronil, a phenylpyrazole insecticide with a similar mode of action to cyclodienes. To investigate the possible occurrence of these mutations in the cat flea, Ctenocephalides felis (Bouché), a 176-bp fragment of the cat flea Rdl gene, encompassing the mutation site, was PCR amplified and sequenced from nine laboratory flea strains. The A302S mutation was found in eight of the nine strains analysed, although the relative frequency of the mutant allele varied between strains. Only one strain (R6) was found to be homozygous for the S302 allele in all the individuals tested, and this correlated with previous reports of low-level fipronil resistance in this strain. A PCR-based diagnostic assay, capable of screening individual fleas for this mutation, was developed and used to survey a range of fleas collected at random from veterinary clinics in the UK and USA. The A302S mutation was present at a high frequency in these domestic pet populations.  相似文献   

Retrospective study of indications for and outcome of perineal urethrostomy in cats     

Bass M  Howard J  Gerber B  Messmer M 《The Journal of small animal practice》2005,46(5):227-231

OBJECTIVES: To evaluate indications for and outcome of perineal urethrostomy in cats. METHODS: The medical records of 59 cats that had undergone perineal urethrostomy were evaluated. Short-term follow up information (for a period of four weeks following surgery) was available for all of the cats. Long-term follow up information (for a period of at least four months) was available for 39 cats. RESULTS: Early complications occurred in 25.4 per cent of cats and late complications were observed in 28.2 per cent of cats. The most frequent late complication was recurring bacterial urinary tract Infection. CLINICAL SIGNIFICANCE: Despite frequent complications and recurring signs of lower urinary tract disease, 32.2 per cent of the cats had a disease-free long-term outcome (mean four years, median 3.9 years), and 88.6 per cent of clients interviewed thought that their cats had a good quality of life after surgery.  相似文献   

Effects of oral vitamin E supplementation during late gestation in beef cattle that calved in late winter and late summer     

Bass RT  Swecker WS  Eversole DE 《American journal of veterinary research》2001,62(6):921-927

OBJECTIVE: To determine effects of breed and oral vitamin E supplementation during late gestation on serum vitamin E and IgG concentrations in beef cows that calved in late winter and late summer and in neonatal calves. ANIMALS: 73 Angus and 43 Hereford primiparous and multiparous cows and their calves. PROCEDURE: Cows in groups that were homogeneous regarding breed and age distribution were randomly allotted to groups that were orally supplemented (n = 59) or not supplemented (57) with vitamin E beginning 30 days prior to onset of 65-day calving seasons. Supplemental vitamin E was provided in a vitamin-mineral mix offered free-choice until parturition. RESULTS: Cows that calved in late winter and were supplemented orally with vitamin E had higher serum vitamin E concentrations at calving and after calving than did unsupplemented cows; differences between groups before calving were not significant. Calves from supplemented multiparous cows had higher vitamin E concentrations than did calves from unsupplemented cows. Winter-born calves from supplemented Hereford cows had heavier 205-day adjusted weaning weights than did winter-born calves from unsupplemented Hereford cows. Supplementation did not affect vitamin E or IgG concentrations in the herd that calved in late summer and did not affect calf growth. CONCLUSIONS AND CLINICAL RELEVANCE: Oral vitamin E supplementation during late gestation may be economically beneficial in certain cow-calf operations in which late-gestation cows are consuming stored forages.  相似文献   

Neuroendocrine regulation of growth hormone secretion in sheep. III. Serotoninergic systems.     

G S Spencer  P Dobbie  J J Bass 《Domestic animal endocrinology》1991,8(3):383-391

The role of serotoninergic pathways in the regulation of growth hormone secretion in the sheep has been investigated. Both peripheral and central routes of administration of serotonin agonists and antagonists have been used. Intravenous administration of the serotonin agonist, buspirone, at 1.2 mg/kg/h lowered plasma GH levels (P less than 0.001) but at 0.21 mg/kg/h there was no significant decrease. Intracerebroventricular (icv) administration of serotonin itself also depressed GH levels (P less than 0.01). The serotonin antagonist, cyproheptadine, failed to affect GH concentrations when given either intravenously (0.25 mg/kg/h) or intracerebroventricularly (4 mg). Neither serotonin nor cyproheptadine had any significant effect on plasma glucose or cortisol levels when administered icv. The possible role of somatostatin in mediating the serotonin associated decrease in GH was investigated by concurrent administration of serotonin and a specific, potent anti-somatostatin serum into a cerebral ventricle. This treatment also resulted in a marked, sustained depression in GH (P less than 0.001). These data suggest that serotonin can inhibit release of GH from the pituitary in sheep and that this is independent of hypothalamic somatostatin.  相似文献