Retrospective Evaluation of the Effect of Heart Rate on Survival in Dogs with Atrial Fibrillation          下载免费PDF全文

B. Pedro  J. Dukes‐McEwan  M.A. Oyama  M.S. Kraus  A.R. Gelzer 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):86-92

Background

Atrial fibrillation (AF) usually is associated with a rapid ventricular rate. The optimal heart rate (HR) during AF is unknown.

Hypothesis/Objectives

Heart rate affects survival in dogs with chronic AF.

Animals

Forty‐six dogs with AF and 24‐hour ambulatory recordings were evaluated.

Methods

Retrospective study. Holter‐derived HR variables were analyzed as follows: mean HR (meanHR, 24‐hour average), minimum HR (minHR, 1‐minute average), maximum HR (maxHR, 1‐minute average). Survival times were recorded from the time of presumed adequate rate control. The primary endpoint was all‐cause mortality. Cox proportional hazards analysis identified variables independently associated with survival; Kaplan‐Meier survival analysis estimated the median survival time of dogs with meanHR <125 bpm versus ≥125 bpm.

Results

All 46 dogs had structural heart disease; 31 of 46 had congestive heart failure (CHF), 44 of 46 received antiarrhythmic drugs. Of 15 dogs with cardiac death, 14 had CHF. Median time to all‐cause death was 524 days (Interquartile range (IQR), 76–1,037 days). MeanHR was 125 bpm (range, 62–203 bpm), minHR was 82 bpm (range, 37–163 bpm), maxHR was 217 bpm (range, 126–307 bpm). These were significantly correlated with all‐cause and cardiac‐related mortality. For every 10 bpm increase in meanHR, the risk of all‐cause mortality increased by 35% (hazard ratio, 1.35; 95% CI, 1.17–1.55; P < 0.001). Median survival time of dogs with meanHR<125 bpm (n = 23) was significantly longer (1,037 days; range, 524‐open) than meanHR ≥125 bpm (n = 23; 105 days; range, 67–267 days; P = 0.0012). Mean HR was independently associated with all‐cause and cardiovascular mortality (P < 0.003).

Conclusions and Clinical Importance

Holter‐derived meanHR affects survival in dogs with AF. Dogs with meanHR <125 bpm lived longer than those with meanHR ≥ 125 bpm.  相似文献   

Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH‐Cytochrome B5 Reductase Gene          下载免费PDF全文

H. Shino  Y. Otsuka‐Yamasaki  T. Sato  K. Ooi  O. Inanami  R. Sato  M. Yamasaki 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):165-171

Background

In veterinary medicine, congenital methemoglobinemia associated with nicotinamide adenine dinucleotide (NADH)‐cytochrome b5 reductase (b5R) deficiency is rare. It has been reported in several breeds of dogs, but little information is available about its etiology.

Objectives

To analyze the NADH‐cytochrome b5 reductase gene, CYB5R3, in a Pomeranian dog family with methemoglobinemia suspected to be caused by congenital b5R deficiency.

Animals

Three Pomeranian dogs from a family with methemoglobinemia were analyzed. Five healthy beagles and 5 nonrelated Pomeranian dogs without methemoglobinemia were used as controls.

Methods

Methemoglobin concentration, b5R activity, and reduced glutathione (GSH) concentration were measured, and a turbidity index was used to evaluate Heinz body formation. The CYB5R3 genes of the affected dog and healthy dogs were analyzed by direct sequencing.

Results

Methemoglobin concentrations in erythrocytes of the affected dogs were remarkably higher than those of the control dogs. The b5R activity of the affected dogs was notably lower than that of the control dogs. DNA sequencing indicated that this Pomeranian family carried a CYB5R3 gene missense variant (ATC→CTC at codon 194) that resulted in the replacement of isoleucine (Ile) by leucine (Leu).

Conclusions and Clinical Importance

This dog family had familial congenital methemoglobinemia caused by b5R deficiency, which resulted from a nonsynonymous variant in the CYB5R3 gene. This variation (c.580A>C) led to an amino acid substitution (p.Ile194Leu), and Ile194 was located in the proximal region of the NADH‐binding motif. Our data suggested that this variant in the canine CYB5R3 gene would affect function of the b5R in erythrocytes.  相似文献   

Barriers to and enablers of implementing antimicrobial stewardship programs in veterinary practices          下载免费PDF全文

Laura Y. Hardefeldt  J. R. Gilkerson  H. Billman‐Jacobe  M. A. Stevenson  K. Thursky  K. E. Bailey  G. F. Browning 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(3):1092-1099

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Water requirements of canine athletes during multi‐day exercise          下载免费PDF全文

Lara Stephens‐Brown  Michael Davis 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(3):1149-1154

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Fractional excretion of electrolytes in volume‐responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications          下载免费PDF全文

Roberta Troìa  Marta Gruarin  Chiara Grisetti  Federica Serafini  Luca Magna  Erika Monari  Massimo Giunti  Francesco Dondi 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(4):1372-1382

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Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease          下载免费PDF全文

Cristiane C. Otoni  Romy M. Heilmann  Mercedes García‐Sancho  Angel Sainz  Mark R. Ackermann  Jan S. Suchodolski  Jörg M. Steiner  Albert E. Jergens 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(3):999-1008

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Immunohistochemical differentiation of reactive from malignant mesothelium as a diagnostic aid in canine pericardial disease          下载免费PDF全文

E. Milne  Y. Martinez Pereira  C. Muir  T. Scase  D. J. Shaw  G. McGregor  L. Oldroyd  E. Scurrell  M. Martin  C. Devine  H. Hodgkiss‐Geere 《The Journal of small animal practice》2018,59(5):261-271

Objectives

To develop a provisional immunohistochemistry panel for distinguishing reactive pericardium, atypical mesothelial proliferation and mesothelioma in dogs.

Materials and Methods

Archived pericardial biopsies were subject to haematoxylin and eosin staining, immunohistochemistry for cytokeratin, vimentin, insulin‐like growth factor II mRNA‐binding protein 3, glucose transporter 1 and desmin. Samples were scored for intensity and number of cells stained.

Results

Ten biopsies of reactive mesothelium, 17 of atypical mesothelial proliferation, 26 of mesothelioma and five of normal pericardium were identified on the basis of haematoxylin and eosin staining. Cytokeratin and vimentin were expressed in all biopsies, confirming mesothelial origin. Normal pericardial samples had the lowest scores for insulin‐like growth factor II mRNA‐binding protein 3, glucose transporter 1 and desmin. Mesothelioma and atypical proliferative samples were similar to each other, with higher scores for insulin‐like growth factor II mRNA‐binding protein 3 and glucose transporter 1 than the reactive samples. Desmin staining was variable. Insulin‐like growth factor II mRNA‐binding protein 3 was the best to distinguish between disease groups.

Clinical Significance

An immunohistochemistry panel of cytokeratin, vimentin, insulin‐like growth factor II mRNA‐binding protein 3 and glucose transporter 1 could provide superior information compared with haematoxylin and eosin staining alone in the diagnosis of cases of mesothelial proliferation in canine pericardium, but further validation is warranted.  相似文献   

Shortening of an existing generic online health‐related quality of life instrument for dogs          下载免费PDF全文

J. Reid  L. Wiseman‐Orr  M. Scott 《The Journal of small animal practice》2018,59(6):334-342

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Use of two doses of cloprostenol in different intervals for estrus synchronization in hair sheep under tropical conditions     

de Carvalho Menezes de Almeida  Sheylla Foligno  Souza-Fabjan  Joanna Maria Gonçalves  Balaro  Mario Felipe Alvarez  Bragança  Gláucia Mota  Pinto  Pedro Henrique Nicolau  de Almeida  José Gabriel  Moura  Ana Beatriz Bossois  da Fonseca  Jeferson Ferreira  Brandão  Felipe Zandonadi 《Tropical animal health and production》2018,50(2):427-432

Tropical Animal Health and Production - This study evaluated the effect of two doses of prostaglandin at different intervals on reproductive parameters of crossbred ewes. In Experiment 1, 30 ewes...  相似文献   

Anatomical characterization of hoof growth pattern in six Iranian sheep breeds and its possible implication for trimming recommendations     

Azarpajouh  S.  Marchewka  J.  Segura Correa  J. C.  Calderón Díaz  J. A. 《Tropical animal health and production》2018,50(6):1343-1348

Tropical Animal Health and Production - The objective of this study was to compare hoof anatomy, hoof growth pattern, and hoof weight-bearing surface of six different Iranian sheep breeds to...  相似文献