A quantitative approach to analysing cortisol response in the horse          下载免费PDF全文

C. Ekstrand  C. Ingvast‐Larsson  L. Olsén  M. Hedeland  U. Bondesson  J. Gabrielsson 《Journal of veterinary pharmacology and therapeutics》2016,39(3):255-263

The cortisol response to glucocorticoid intervention has, in spite of several studies in horses, not been fully characterized with regard to the determinants of onset, intensity and duration of response. Therefore, dexamethasone and cortisol response data were collected in a study applying a constant rate infusion regimen of dexamethasone (0.17, 1.7 and 17 μg/kg) to six Standardbreds. Plasma was analysed for dexamethasone and cortisol concentrations using UHPLC‐MS/MS. Dexamethasone displayed linear kinetics within the concentration range studied. A turnover model of oscillatory behaviour accurately mimicked cortisol data. The mean baseline concentration range was 34–57 μg/L, the fractional turnover rate 0.47–1.5 1/h, the amplitude parameter 6.8–24 μg/L, the maximum inhibitory capacity 0.77–0.97, the drug potency 6–65 ng/L and the sigmoidicity factor 0.7–30. This analysis provided a better understanding of the time course of the cortisol response in horses. This includes baseline variability within and between horses and determinants of the equilibrium concentration–response relationship. The analysis also challenged a protocol for a dexamethasone suppression test design and indicated future improvement to increase the predictability of the test.  相似文献   

Nanoemulsion formulation of florfenicol improves bioavailability in pigs          下载免费PDF全文

M.‐Y. Qian  L. Wei  D. Zhou  Z.‐J. Zhang  J.‐K. He  Q.‐J. Zhang  P. Zhu  X.‐L. Xiao 《Journal of veterinary pharmacology and therapeutics》2016,39(1):84-89

Nanotechnology applications in medicine have seen a tremendous growth in the past decade and are being employed to enhance the stability and bioavailability of lipophilic substances, such as florfenicol. This study aimed to examine the pharmacokinetic properties of the formulated oil‐in‐water florfenicol‐loaded nanoemulsion (FF‐NE). FF‐NE and florfenicol control (Nuflor^®) were administered to the pigs at a dose of 20 mg/kg. Nanoemulsion formulation of florfenicol was highly influenced in vivo plasma profile. The in vivo absorption study in pigs indicated that C_max (14.54 μg/mL) was significantly higher in FF‐NE, 3.42 times higher than the marketed formulation. In comparison with the control group, the relative bioavailability of formulated nanoemulsion was up to 134.5%. Assessment of bioequivalence using log‐transformed data showed that the 90% confidence intervals (90% CI) of C_max and AUC_0–∞ were 2.48–4.60 and 1.21–1.72, respectively.  相似文献   

Urolithiasis in chinchillas: 15 cases (2007 to 2011)          下载免费PDF全文

A. Martel‐Arquette  C. Mans 《The Journal of small animal practice》2016,57(5):260-264

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Conservative management of an atlantoaxial subluxation using thermoplastic material          下载免费PDF全文

E. L. Hall  J. Guevar  K. L. Holmes  R. Gutierrez‐Quintana 《The Journal of small animal practice》2016,57(7):386-386

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Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses          下载免费PDF全文

Andres F. Sanchez‐Teran  José L. Bracamonte  Steven Hendrick  Hilary J. Burguess  Tanya Duke‐Novakovski  Monica Schott  Brent Hoff  Luis M. Rubio‐Martínez 《Veterinary surgery : VS》2016,45(2):223-230

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Development of a Novel Medial Synoviocentesis Approach to the Bicipital Bursa in an Equine Cadaver Model          下载免费PDF全文

Milosz Grabski  Jennifer McNamara  Darren Roper  Chris Warren‐Smith  Evita Busschers 《Veterinary surgery : VS》2016,45(4):523-528

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Anatomical Variations of the Blood Vascular System in Veterinary Medicine. The Internal Iliac Artery of the Dog. Part Two          下载免费PDF全文

L. Avedillo  N. Martín‐Alguacil  I. Salazar 《Anatomia, histologia, embryologia》2016,45(2):88-99

The aim of this study was to investigate the variability of the internal pudendal artery. Two hundred and thirty‐two pelvic halves from 116 adult dogs were examined. Twenty‐six anatomical variations were found, thirteen occurring in more than 5% of the dogs. Anatomical variations were grouped in relation to the origin of the prostatic/vaginal arteries, middle rectal artery, urethral artery, ventral perineal and caudal rectal arteries. The chi‐squared test was used to analyse differences in sex, side of the body, profile and size, and the results were considered statistically significant when P ≤ 0.05. An identical vascular pattern in both hemipelvises was found for most of the anatomical variations described.  相似文献   

Anatomical Variations of the Blood Vascular System in Veterinary Medicine: The Internal Iliac Artery of the Dog — Part Three          下载免费PDF全文

L. Avedillo  N. Martín‐Alguacil  I. Salazar 《Anatomia, histologia, embryologia》2016,45(3):189-196

The aim of this study was to analyse and describe the variability of the umbilical artery. Two hundred and thirty‐two pelvic halves from 116 adult dogs were examined. To study the permeability of the umbilical artery, ten adult dogs, nine newborns and thirteen foetuses between 35 and 50 days of gestation were also used. In relation to the origin of the umbilical artery, six anatomical variations were found. From which five involved a cranial (n = 4) or caudal (n = 1) relocation of its origin, and in one case (n = 1), the umbilical artery arose from the median sacral artery. In eight cases, the umbilical artery gave off the prostatic (n = 1) or vaginal (n = 7) arteries. The permeability of the umbilical artery was the most significant anatomical variation: permeability was detected in 45% (106 of 232 pelvic halves) of all cases, from which 36 were males and 70 females. Interestingly, an equal vascular permeability in both hemipelvises was found for 82% of the dogs, thus additional data related to such feature of the umbilical artery was also recorded. In accordance with the statistical study, the main anatomical variations described showed significant values for gender, side of the body, size and profile variables.  相似文献   

Anatomical Atlas of the Quail's Ear (Coturnix coturnix)          下载免费PDF全文

A. Bonsmann  M. H. Stoffel  M. Burkhart  J.‐M. Hatt 《Anatomia, histologia, embryologia》2016,45(5):399-404

This study aims to enhance the anatomical knowledge of the ear of the adult quail (Coturnix coturnix) through the creation of a scaled 3D model utilizing data from micro‐CT images. In addition, 17 annotated histological sections of the quail's ear are aligned to their 3D position in the model. The resulting anatomical atlas provides an intuitive insight into the 3D anatomy and can be used for medical education. The model also allows measuring anatomical structures and can thus serve as reference for the quail's auricular anatomy and as a basis to evaluate clinical diagnostic imaging results.  相似文献   

What is your diagnosis? Clitoral mass in a dog          下载免费PDF全文

Emily D. Rout  Laura L. Hoon‐Hanks  Tanya L. Gustafson  E.J. Ehrhart  Amy L. MacNeill 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2016,45(1):197-198

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