Primary pulmonary neoplasia in cats: assessment of computed tomography findings and survival          下载免费PDF全文

J. Nunley  J. Sutton  W. Culp  D. Wilson  K. Coleman  R. Demianiuk  A. Schechter  G. Moore  T. Donovan  P. Schwartz 《The Journal of small animal practice》2015,56(11):651-656

  相似文献   

Assessment of the Efficacy and Potential Complications of Transjugular Liver Biopsy in Canine Cadavers     

A.S. Levien  C. Weisse  T.A. Donovan  A.C. Berent 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(2):338-345

Background

Transjugular liver biopsy (TJLB) is used in humans at risk of bleeding. There are no reports of its use in veterinary medicine.

Objective

To assess the efficacy and potential complications of TJLB in canine cadavers, and compare with samples obtained via needle liver biopsy (NLB) and surgical liver biopsy (SLB).

Animals

Twenty‐five medium and large breed canine cadavers.

Methods

Prospective study. TJLBs were procured through the right jugular vein. After biopsy, intravenous contrast and gross inspection were used to assess the biopsy site. Minor and major complications were recorded. NLBs and SLBs were then obtained. Histopathology was performed, and TJLB and NLB were compared for number of complete portal tracts (CPTs), length, and fragmentation. Pathologic process and autolysis were assessed in all samples.

Results

All TJLBs yielded liver tissue. The proportion of minor complications was 12/25 (48%), and major complications 16/25 (64%); 13/16 (81%) of the major complications were liver capsule perforation. In 21/25 (84%), the histopathology in the SLB was reflected in the TJLBs. For cases with minimal autolysis, median number of CPTs in TJLBs was 7.5, compared with 4 in NLBs (P = .018). Median length of TJLB specimen was 28 mm compared to 22 mm in NLBs (P = .007). Fragmentation rate was median of 1.25 for TJLB compared to 1.50 in NLBs (P = .11).

Conclusions and Clinical Importance

TJLB is technically feasible and achieves comparable results to NLB and SLB. The number of complications, in particular liver capsule perforation, was greater than expected. Further studies are indicated before clinical use is recommended.  相似文献   

猪的回肠炎及其控制   总被引：1，自引：0，他引：1  

Jim O Donovan  余春明  徐镔蕊 《中国畜牧兽医》2002,29(4):46-47

猪的增生性回肠病 (回肠炎 )最早在 1 931年被发现 ,但直到约 60年后 ,本病的病原体由爱丁堡大学的 lawson等人命名为 lawsonia intracellu-laris。随后的 1 0年中由于许多特有技术的发展 ,使得人们可进一步研究这种细菌感染的流行病学和它的各种临床表现 -即地方性回肠炎 ( RI)、增生性肠病 ( PE)、坏死性肠炎 ( NE)和急性出血增生性肠病 ( AHPE)。所有疾病的控制方案都是以流行病学为基础的。有关病原体和传播方式的许多问题仍待解决。1　流行病学分子诊断技术可用于整个畜群抽查并可检测它们粪便中的 L intracellularis。西班牙对 7…  相似文献   

Occipito-atlanto-axial malformation with atlanto-axial subluxation in an ataxic calf     

A G Watson  J H Wilson  A J Cooley  G A Donovan  C P Spencer 《Journal of the American Veterinary Medical Association》1985,187(7):740-742

Occipito-atlanto-axial malformation with atlanto-axial subluxation was diagnosed radiographically in a 4-day-old Holstein calf with a short neck, symmetric ataxia, and tetraparesis, indicative of a cervical spinal cord lesion. Necropsy confirmed the clinical diagnosis and revealed ribs on C-7, with partial fusion of C-7 and T-1. Histologic examination revealed focal degeneration of the spinal cord in the second cervical segment at the level of the atlanto-axial joint and extensive secondary neuronal fiber degeneration possibly caused by spinal cord trauma that occurred in utero.  相似文献   

Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis     

Spruck CH  de Miguel MP  Smith AP  Ryan A  Stein P  Schultz RM  Lincoln AJ  Donovan PJ  Reed SI 《Science (New York, N.Y.)》2003,300(5619):647-650

We generated mice lacking Cks2, one of two mammalian homologs of the yeast Cdk1-binding proteins, Suc1 and Cks1, and found them to be viable but sterile in both sexes. Sterility is due to failure of both male and female germ cells to progress past the first meiotic metaphase. The chromosomal events up through the end of prophase I are normal in both CKS2-/- males and females, suggesting that the phenotype is due directly to failure to enter anaphase and not a consequence of a checkpoint-mediated metaphase I arrest.  相似文献   

Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis     

Jin J  Desai BN  Navarro B  Donovan A  Andrews NC  Clapham DE 《Science (New York, N.Y.)》2008,322(5902):756-760

  相似文献   

High-throughput mapping of a dynamic signaling network in mammalian cells     

Barrios-Rodiles M  Brown KR  Ozdamar B  Bose R  Liu Z  Donovan RS  Shinjo F  Liu Y  Dembowy J  Taylor IW  Luga V  Przulj N  Robinson M  Suzuki H  Hayashizaki Y  Jurisica I  Wrana JL 《Science (New York, N.Y.)》2005,307(5715):1621-1625

Signaling pathways transmit information through protein interaction networks that are dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput technology, to map protein-protein interaction networks systematically in mammalian cells and applied it to the transforming growth factor-beta (TGFbeta) pathway. Analysis using self-organizing maps and k-means clustering identified links of the TGFbeta pathway to the p21-activated kinase (PAK) network, to the polarity complex, and to Occludin, a structural component of tight junctions. We show that Occludin regulates TGFbeta type I receptor localization for efficient TGFbeta-dependent dissolution of tight junctions during epithelial-to-mesenchymal transitions.  相似文献   

In vitro isolation of Cowdria ruminantium from plasma of infected ruminants   总被引：1，自引：0，他引：1  

B Byrom  C E Yunker  P L Donovan  G E Smith 《Veterinary microbiology》1991,26(3):263-268

A new and simple technique for isolation of C. ruminantium in bovine and ovine vascular endothelial cells (aorta, pulmonary artery) is described. Unlike previous studies, no efforts were made to retard cell growth by irradiation or chemicals. Instead, heparin-derived plasma samples obtained from only those animals exhibiting prolonged or extremely high temperatures were used. In this way, C. ruminantium was isolated from 27 of 37 samples (73%) and from 22 of 26 animals (85%). A total of six Zimbabwean stocks of C. ruminantium were isolated in cell culture.  相似文献   

Evaluation of production per day of life calculated on cull cows as a comprehensive monitor of dairy herd performance     

P. L. Ruegg  I. R. Dohoo  G. A. Donovan 《Preventive veterinary medicine》1992,14(3-4):241-249

The primary objective of this study was to determine the contribution of several management variables to average production per day of life (PPDL). A secondary objective was to compare PPDL between two geographic regions in North America and between dairy herds within the two regions. PPDL was determined for animals culled from four ‘large’ dairy farms in Florida, USA (FL), and eight ‘small’ dairy farms in Prince Edward Island, Canada (PEI). Average milk PPDL was calculated by summing the kilograms of milk produced per cow and dividing by the total number of days from birth until culling. PPDL for the four FL herds (9.50 kg day⁻¹) was significantly higher than PPDL for the eight PEI herds (8.64 kg day⁻¹). PPDL increased in a quadratic fashion with number of lactations. PPDL did not differ between the eight PEI herds. Significant differences in PPDL were identified between the four FL dairy farms.

The regression of PPDL on average lactational milk yield (AVGFCM), number of lactations (LACT), age at first calving and average days to conception explained 94.5% and 92.4% of the variation of PPDL for multiparous cows in the PEI and FL herds, respectively. One variable (AVGFCM) accounted for 68% and 55% of the variance in PPDL for PEI and FL, respectively. The addition of LACT to the model explained 87% and 81% of the variance in PPDL for PEI and FL, respectively.  相似文献   

Lipids and lipoproteins in normal dogs and in dogs with secondary hyperlipoproteinemia.     

W A Rogers  E F Donovan  G J Kociba 《Journal of the American Veterinary Medical Association》1975,166(11):1092-1100

Concentrations of serum cholesterol, triglyceride, and free glycerol were neasured, and serum lipoprotein electrophoresis was performed in normal dogs and in dogs with hypothyroidism, diabetes mellitus, and acute pancreatitis. Twelve privately owned dogs and 20 Basset Hounds from a research colony served as normal subjects. Privately owned had higher serum lipid concentrations than did research dogs. On electrophorisis of normal dog serum, lipoprotein bands were detected at the beta, pre-beta, alpha-2, and alpha-1 positions. Hypercholesterolemia was associated with increased intensity of the alpha-2-lipoprotein band, and hypertriglyceridemia occurred with increased lipoprotein at the origin, or the beta or pre-beta positions. Hypothyroid dogs had normal lipid values and lipoprotein electrophoretic patterns, hypercholesterolemia with increased intensity of the alpha-2-lipoprotein band, or hypercholesterolemia and hypertiglyceridemia with prominent beta-, pre-beta, and alpha-2-lipoprotein electrophoretic patterns were changed to near-normal values after levothyroxine administration. Diabetic dogs had increased serum cholesterol and triglyceride content and a predominance of lower density lipoproteins, as detected by electrophoresis. Insulin therapy caused the lipid concentrations to decrease and the electrophoretic pattern to revert to near normal. Dogs with acute pancreatitis had moderately increased serum lipid content and electrophoretic patterns characterized by increased intensity of the beta-lipoprotein band and by altered migration of alpha-1-lipoproteins.  相似文献