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31.
Schmitt JP Kamisago M Asahi M Li GH Ahmad F Mende U Kranias EG MacLennan DH Seidman JG Seidman CE 《Science (New York, N.Y.)》2003,299(5611):1410-1413
Molecular etiologies of heart failure, an emerging cardiovascular epidemic affecting 4.7 million Americans and costing 17.8 billion health-care dollars annually, remain poorly understood. Here we report that an inherited human dilated cardiomyopathy with refractory congestive heart failure is caused by a dominant Arg --> Cys missense mutation at residue 9 (R9C) in phospholamban (PLN), a transmembrane phosphoprotein that inhibits the cardiac sarcoplasmic reticular Ca2+-adenosine triphosphatase (SERCA2a) pump. Transgenic PLN(R9C) mice recapitulated human heart failure with premature death. Cellular and biochemical studies revealed that, unlike wild-type PLN, PLN(R9C) did not directly inhibit SERCA2a. Rather, PLN(R9C) trapped protein kinase A (PKA), which blocked PKA-mediated phosphorylation of wild-type PLN and in turn delayed decay of calcium transients in myocytes. These results indicate that myocellular calcium dysregulation can initiate human heart failure-a finding that may lead to therapeutic opportunities. 相似文献
32.
Niki Alexi Alexandru Luca Evangelia Nanou Derek V. Byrne Kriton Grigorakis 《Aquaculture Research》2020,51(6):2443-2455
Greater amberjack is one of the major candidate species for aquaculture diversification; however, with the exception of sporadic data on the proximate (PC) and fatty acid (FA) composition, limited knowledge exists regarding the quality variations occurring between wild and reared Greater amberjack. To expand this knowledge, the current study examined, besides the PC and FA composition of raw tissue, the volatile compounds (VC) and sensory profiles of cooked tissue. The studied specimens originated both from the wild and from aquaculture and were of small commercial size (0.5–1 kg). The FA profiles varied with most profound differences being the lower n‐6/n‐3 ratio and the higher arachidonic (ARA) and docohexaenoic acid (DHA) proportions of wild counterparts. A superior lipid quality was found for reared fish, which was attributed, among other reasons to their significantly (p < .001) higher fillet lipid (wild: 0.27%; reared: 3.92%). The VC profiles differed with rearing origin. Reared Greater amberjack exhibited a significantly higher content in the majority of aromatic hydrocarbons and terpenes, while wild exhibited higher contents for the majority of compounds belonging to the alcohol, aldehyde and ketone groups. Minor sensory profile differences were observed, with reared and wild counterparts exhibiting higher butter and sardine flavour, respectively. 相似文献