Potentiation of 5-Fluorouracil Inhibition of Flexner-Jobling Carcinoma by Glucose     

Kung SS  Goldberg ND  Dahl JL  Parks RE  Kline BE 《Science (New York, N.Y.)》1963,141(3581):627-628

A significant potentiation of the antitumor action of 5-fluorouracil in rats bearing the Flexner-Jobling carcinoma is produced by the intraperitoneal administration of large doses of glucose.  相似文献   

Morphine: conditioned increases in self-administration in rhesus monkeys   总被引：1，自引：0，他引：1  

S R Goldberg  J H Woods  C R Schuster 《Science (New York, N.Y.)》1969,166(910):1306-1307

Operant responding in three monkeys was maintained by intravenous presentations of morphine. Nalorphine produced reliable increases in morphine-reinforced responding. With successive daily nalorphine injections there was a decreased latency of self-administration responding for morphine, and substituted saline injections produced conditioned increases in morphine-reinforced responding.  相似文献   

Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles   总被引：26，自引：0，他引：26  

P Libby  A L Goldberg 《Science (New York, N.Y.)》1978,199(4328):534-536

The protease inhibitor leupeptin decreases protein degradation in rat skeletal and cardiac muscle incubated in vitro, while protein synthesis remains unaltered. Leupeptin also lowers protein breakdown in denervated rat muscles and affected muscles from mice with hereditary muscular dystrophy. Leupeptin may thus be useful in retarding tissue atrophy. Since homogenates of leupeptin-treated muscles had decreased cathepsin B activity, this lysosomal protease may play a role in protein turnover in normal and diseased muscles.  相似文献   

Formation of regulatory patterns during signal propagation in a Mammalian cellular network     

Ma'ayan A  Jenkins SL  Neves S  Hasseldine A  Grace E  Dubin-Thaler B  Eungdamrong NJ  Weng G  Ram PT  Rice JJ  Kershenbaum A  Stolovitzky GA  Blitzer RD  Iyengar R 《Science (New York, N.Y.)》2005,309(5737):1078-1083

We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity.  相似文献   

Ferruginous conditions dominated later neoproterozoic deep-water chemistry     

Canfield DE  Poulton SW  Knoll AH  Narbonne GM  Ross G  Goldberg T  Strauss H 《Science (New York, N.Y.)》2008,321(5891):949-952

Earth's surface chemical environment has evolved from an early anoxic condition to the oxic state we have today. Transitional between an earlier Proterozoic world with widespread deep-water anoxia and a Phanerozoic world with large oxygen-utilizing animals, the Neoproterozoic Era [1000 to 542 million years ago (Ma)] plays a key role in this history. The details of Neoproterozoic Earth surface oxygenation, however, remain unclear. We report that through much of the later Neoproterozoic (<742 +/- 6 Ma), anoxia remained widespread beneath the mixed layer of the oceans; deeper water masses were sometimes sulfidic but were mainly Fe2+-enriched. These ferruginous conditions marked a return to ocean chemistry not seen for more than one billion years of Earth history.  相似文献   

THE DAILY REMOVAL OF FORMALIN FROM PRESERVED BIOLOGICAL SPECIMENS USED IN CLASS WORK     

Fort WB  Wilson HC  Goldberg HG 《Science (New York, N.Y.)》1941,94(2433):169-170

  相似文献   

Validity and reliability of a calcium checklist in early elementary-school children     

Marcotte L  Hennessy E  Dwyer J  Hyatt RR  Goldberg JP  Naumova EN  Economos CD 《Public health nutrition》2008,11(1):57-64

OBJECTIVE: To create, validate and assess the reliability of a checklist to measure calcium intake in children. DESIGN: Calcium intakes from a checklist and parent-assisted 24-h dietary recall were compared. Checklist reliability was assessed separately. SETTING: After-school programmes in the United States. SUBJECTS: Forty-two children (18 males, 24 females, age = 8.0 +/- 0.9 years) participated in the validation analysis and 49 children (28 males, 21 females, age = 7.5 +/- 0.9 years) in the reliability analysis. RESULTS: No differences in mean calcium intakes were found by method or gender. The checklist correlated well with recall among girls (r = 0.65, P = 0.01) but not boys (r = -0.33, P = 0.19). Agreement over time was above 80% for most foods. CONCLUSION: The calcium checklist is useful for assessing calcium intake among groups of 6-10-year-old children in settings that preclude parental assistance. More research is needed to improve accuracy among boys.  相似文献   

Natural Colonization of Rice by Arbuscular Mycorrhizal Fungi in Different Production Areas   总被引：1，自引：0，他引：1  

Lina Bernaola  Grace Cange  Michael O. Way  Jeffrey Gore  Jarrod Hardke  Michael Stout 《水稻科学》2018,25(3):169-174

Interactions between plants and soil microorganisms can influence the other interactions in which plants participate, including interactions with herbivores. Many fungi, including arbuscular mycorrhizal fungi(AMF), form symbiotic relationships with the roots they inhabit, and potentially alter defense against pests. The objective of this study was to document the extent of root colonization by AMF on non-flooded rice plants grown under conditions typical of commercial fields. We hypothesized that AMF naturally colonized rice plants in different rice producing field locations. Rice plant samples were collected from areas across the southern United States, including Texas, Mississippi, Arkansas and two research stations in Louisiana. We quantified the amount of AMF colonization in insecticide-free rice plants over three consecutive years(2014–2016). The results revealed natural colonization of AMF in all rice producing areas. In all the three years of survey, rice-AMF associations were the greatest in Arkansas followed by Mississippi and Texas. This research will help draw attention to natural colonization of AMF in rice producing areas that can impact future rice research and production by facilitating agricultural exploitation of the symbiosis.  相似文献   

Comparative Study of Proximate,Chemical and Physicochemical Properties of Less Explored Tropical Leafy Vegetables     

Grace Oluwakemi Babarinde  Victoria Funmilayo Abioye  Odunayo Omobitan  Kassim Raji 《东北农业大学学报(英文版)》2018,(1):16-23

The list of underutilized green leafy vegetables is enormous: ranging from commonly consumed and underutilized vegetables. There are data on commonly consumed vegetables, but information is sparse on nutritional, chemical and anti-nutritional properties of less explored vegetables. This work aimed to evaluate some attributes of less explored or underutilized leafy vegetables. Some nutritional and anti-nutritional contents of 10 under-utilized leafy vegetables(Amaranthus spinosus Linnaeus, Basella alba Linnaeus, Corchorous tridens L., Cyrtosperma senegalense(Schott), Erigeron floribundus Sch, Hoslundia opposita Vahl, Lagenaria siceraria(Molina) Standl, Ocimum basilicum L., Solanum aethiopicum L. and Talinum portulacifolium(Forssk.) Asch. ex Schweinf) were investigated. Cyrtosperma senegalense had the highest protein value(5.93%). Hoslundia opposita had the highest fat content(0.54%). Amaranthus spinosus was high in β-carotene content(346.3 mg · 100 g-1); Cyrtosperma senegalense had the highest moisture content. A. spinosus had the highest ascorbic acid content(108.1 mg · 100 g-1). The highest tannin level(0.0057%) was found in C. senegalense and the lowest(0.0003%) was found in Solanum aethiopicum. Saponin was the highest in C. tridens(0.0052%) and the lowest in T. portulacifolium(0.00014%). C. senegalense and S. aethiopicum had their highest and the lowest phytate values, respectively. Although anti-nutrients could interfere with nutrient utilization, their values in these vegetables were not at toxic levels.  相似文献