Myopathy in a Haflinger horse: An initiating search for a fatty acid oxidation deficiency     

I. D. Wijnberg  W. Ruitenbeek  G. Jansen  C. M. Westermann  J. H. van der Kolk 《Equine Veterinary Education》2008,20(10):532-538

So far, the area of fat metabolism disturbances has been poorly explored in the horse but, as in man, deficiencies in the β‐oxidation of fatty acids (FAOX) and in carnitine metabolism or carnitine transport potentially can be a cause of myopathy. A 9‐year‐old Haflinger patient with recurrent rhabdomyolysis and 5 healthy horses of various breeds with a mean age of 16 ± 5.9 years were used as a comparison. Blood biochemical analysis revealed elevated aspartate amino transferase, lactate dehydrogenase and creatine kinase activities. Plasma vitamin E concentration was low and selenium was within the reference range. Quantitative electromyography was indicative of myopathy based on the short duration and low amplitude motor unit action potentials. Staining of muscle biopsies was suggestive for a myopathy based on a disturbance in fat catabolism. Carnitine, acylcarnitines, very‐long‐chain fatty acids and organic acids screening in blood and urine established no differences between these parameters in the patient and control horses. Even though this patient was negative on FAOX or carnitine disturbances, the potency of the applied methods seems large and indicates a potential diagnostic value.  相似文献   

Epidemiological investigation of infectious salmon anaemia (ISA) outbreaks in Norway 2003-2005     

Lyngstad TM  Jansen PA  Sindre H  Jonassen CM  Hjortaas MJ  Johnsen S  Brun E 《Preventive veterinary medicine》2008,84(3-4):213-227

Epidemiological information was summarized from 32 outbreaks of infectious salmon anaemia (ISA) on salmon farming sites in Norway in 2003–2005. Virus isolates from the outbreak sites were genotyped, and the genotyping was used to assess possible associations between outbreak sites due to adjacent location, sharing fish farming authorisation, sharing smolt suppliers or sharing broodfish origin of the fish. The ISA outbreaks were distributed along most of the Norwegian coast and showed a variable clinical picture. The virus genotypes clustered into three genogroups. Pairs of outbreak sites matched for adjacent location or registered under the same authorisation, all shared genogroup, which was a significantly higher number of corresponding genogroups than expected by chance. For outbreak sites sharing smolt suppliers, corresponding genogroups appeared in 7 out of 12 matched pairs, which was not significant. An evaluation of broodfish origin associated with genogroups did not support transmission linked to broodfish origin. In conclusion, genotyping of virus isolates from ISA outbreaks supports associations between adjacent outbreaks. This is consistent with horizontal transmission. The present study failed to find evidence for vertical transmission (patterns of genogroups related to smolt suppliers or broodfish companies were not identified).  相似文献   

End-stage kidney disease probably due to reflux nephropathy with segmental hypoplasia (Ask-Upmark kidney) in young Boxer dogs in Norway. A retrospective study     

Kolbjørnsen O  Heggelund M  Jansen JH 《Veterinary pathology》2008,45(4):467-474

This paper is a retrospective morphologic study of 7 young Boxer dogs, showing end-stage kidney lesions compatible with chronic pyelonephritis with severe segmental cortical atrophy and fibrosis, associated with chronic tubulointerstitial inflammation of varying degree. Azotemia was observed in 6 of the 7 cases. The gross kidney lesions were as follows: bilateral small kidneys with numerous segmental cortical scars causing depression of the renal cortical surface. Histologic examination revealed salient atrophy of nephrons, including paucity of glomeruli, glomerulocystic lesions, colloid-filled tubular microcysts, and a conspicuously increased occurrence of arteries with narrowed lumina caused by intimal thickening. These segmental abnormalities were accompanied by pronounced interstitial fibrosis. All but 1 dog showed salient tubulointerstitial lympho-plasmacytic infiltration, which in 3 cases also included diffuse infiltration of polymorphonuclear neutrophilic leukocyte (PMN)-cells and occurrence of tubular PMN-casts. Morphologic signs of abnormal metanephric differentiation (renal dysplasia) were observed in all cases in the form of atypical tubules or asynchronous nephronic development (immature glomeruli) or both. However, other morphologic primary dysplastic features were absent. Based on the morphologic features, it is concluded that the end-stage kidney disease in these young Boxer dogs was the result of chronic atrophic nonobstructive pyelonephritis, most probably caused by vesico-ureteral reflux, compatible with reflux nephropathy causing segmental hypoplasia (Ask-Upmark kidney) in man. It is proposed that atypical tubular epithelium in the form of adenomatoid proliferation of collecting duct epithelial cells should be considered an acquired compensatory lesion, rather than the result of disorganized metanephric development.  相似文献   

Where does Nematodirus battus Crofton & Thomas, 1951, come from?     

J Jansen 《The Veterinary record》1973,92(26):697-698

  相似文献   

Heavy metals and their neutralization related to ornamentals     

C. Van Assche  G. Jansen 《Scientia Horticulturae》1979,11(3):291-297

Selectively working cation exchangers (® Lewatit OC 1029, OC 1030 and OC 1034, Bayer AG, Leverkusen) are very effective for the immobilization of ions of heavy metals (Zn²⁺, Cu²⁺, Pb²⁺). Applied at the calculated doses in a soil and/or substrate contaminated with ions of heavy metals, these cation exchangers withdraw the contaminants from the existing equilibrium system, which results in a neutralization of the fraction of the undesired phytotoxic identities. This method not only offers many possibilities in common peat and leaf mould soils, but gives a guarantee for plant-production in contaminated autochthonous areas and heterochthonous substrates. Ornamental plants and nursery trees developed well, especially in a terminated emission atmosphere, even in very strongly contaminated soils.  相似文献   

The taxonomic position of Clostridium botulinum type c.     

B C Jansen  P C Knoetze 《The Onderstepoort journal of veterinary research》1977,44(2):53-54

Experimental evidence is produced to justify abandoning the practice of subdividing Costridium botulinum Type C into type Calpha and Cbeta.  相似文献   

Past,current and future control of epizootic diseases in South Africa     

B. C. Jansen 《Tropical animal health and production》1969,1(2):96-102

  相似文献   

The toxic antigenic factors produced by Clostridium botulinum types C and D   总被引：15，自引：0，他引：15  

B C Jansen 《The Onderstepoort journal of veterinary research》1971,38(2):93-98

  相似文献   

A survey of abortions and long return intervals in dairy herds in the Huntly district     

K Moller  P E Newling  H J Robson  G J Jansen  J A Meursinge 《New Zealand veterinary journal》1967,15(8):137-142

  相似文献   

Biological and biochemical characterization of isolates of Trypanosoma evansi from Pantanal of Matogrosso--Brazil     

Queiroz AO  Cabello PH  Jansen AM 《Veterinary parasitology》2000,92(2):107-118

Ten isolates of Trypanosoma evansi from the Pantanal region of Brazil, recently derived from coati (Nasua nasua, carnivora, Procyonidae), horses and dogs, were characterized on the basis of biological (experimental infections in Wistar rats) and biochemical (multilocus enzyme eletrophoresis) data. Biological data were analyzed by Nested analysis of variance and Kruskal-Wallis. Marked heterogeneity in virulence was observed in the isolates. Some of the isolates showed an undulating parasitaemia, typical for African trypanosomes. This biological heterogeneity did not correspond with the biochemical homogeneity observed in the T. evansi isolates. T. evansi has one of the widest distributions and greatest range of mammalian hosts and is widely recognized to have evolved from Trypanosoma brucei. Adaptability of T. evansi was not reflected in the variability of biochemical and molecular parameters studied to date. The variability in virulence was very significant, but not correlated with the host from which it was derived. These data suggested that, in the region studied, T. evansi is transmitted among both domestic and sylvatic animals in one single transmission cycle.  相似文献