AGE OF THE HOUNSFIELD BENTONITE     

Kay GM 《Science (New York, N.Y.)》1930,72(1867):365-366

  相似文献   

Biofuels: one of many claims to resources     

Wassenaar T  Kay S 《Science (New York, N.Y.)》2008,321(5886):201

  相似文献   

Identification of focus areas for Australian Bat Lyssavirus potential exposure prevention in the Metro North Hospital and Health Service region     

Fiona May  Kay Mann  Daniel Francis  Megan Young 《Zoonoses and public health》2020,67(6):732-741

Australian Bat Lyssavirus (ABLV) is a fatal rabies‐like disease spread to humans from bats. All people who report bat bites or scratches in Queensland are considered potentially exposed to ABLV and are followed up and treated to prevent ABLV. Preventing members of the public intentionally interacting with bats will reduce the number of potential exposures to ABLV. In order to target public health messaging, this study examines the epidemiology of potential ABLV exposures in Metro North Hospital and Health Service (HHS), a region of Queensland that encompasses metro and rural areas in the south‐east of the state. People who intentionally handled bats during the study period were more likely to be adult (93%), male (60%), scratched (51%) by a megabat (72%) and been potentially exposed while rescuing the bat when it was trapped or injured (72%). The number of potential exposures reported in Queensland has increased since 2013; the same year, a Queensland child died of ABLV. Seasonally, exposures are more common during bat breeding and nursing periods when bats are more active (summer to autumn). Although there were more notifications in a band stretching north from the inner city to northern metro suburbs, notification rates were higher in large rural statistical areas in the north of the HHS. These data will be used to develop geographically targeted ABLV prevention messaging for the general public.  相似文献   

Down's syndrome in adults: brain metabolism   总被引：4，自引：0，他引：4  

M Schwartz  R Duara  J Haxby  C Grady  B J White  R M Kessler  A D Kay  N R Cutler  S I Rapoport 《Science (New York, N.Y.)》1983,221(4612):781-783

The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a 51-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions.  相似文献   

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis     

Winn MP  Conlon PJ  Lynn KL  Farrington MK  Creazzo T  Hawkins AF  Daskalakis N  Kwan SY  Ebersviller S  Burchette JL  Pericak-Vance MA  Howell DN  Vance JM  Rosenberg PB 《Science (New York, N.Y.)》2005,308(5729):1801-1804

Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6). The proline-to-glutamine substitution at position 112, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II and appears to alter the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease.  相似文献   

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity     

Bouillet P  Metcalf D  Huang DC  Tarlinton DM  Kay TW  Köntgen F  Adams JM  Strasser A 《Science (New York, N.Y.)》1999,286(5445):1735-1738

Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological roles for Bim. Lymphoid and myeloid cells accumulated, T cell development was perturbed, and most older mice accumulated plasma cells and succumbed to autoimmune kidney disease. Lymphocytes were refractory to apoptotic stimuli such as cytokine deprivation, calcium ion flux, and microtubule perturbation but not to others. Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins.  相似文献   

FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis     

Imaizumi T  Schultz TF  Harmon FG  Ho LA  Kay SA 《Science (New York, N.Y.)》2005,309(5732):293-297

  相似文献   

Productivity is a poor predictor of plant species richness   总被引：5，自引：0，他引：5  

Adler PB  Seabloom EW  Borer ET  Hillebrand H  Hautier Y  Hector A  Harpole WS  O'Halloran LR  Grace JB  Anderson TM  Bakker JD  Biederman LA  Brown CS  Buckley YM  Calabrese LB  Chu CJ  Cleland EE  Collins SL  Cottingham KL  Crawley MJ  Damschen EI  Davies KF  DeCrappeo NM  Fay PA  Firn J  Frater P  Gasarch EI  Gruner DS  Hagenah N  Hille Ris Lambers J  Humphries H  Jin VL  Kay AD  Kirkman KP  Klein JA  Knops JM  La Pierre KJ  Lambrinos JG  Li W  MacDougall AS  McCulley RL  Melbourne BA  Mitchell CE  Moore JL  Morgan JW  Mortensen B 《Science (New York, N.Y.)》2011,333(6050):1750-1753

For more than 30 years, the relationship between net primary productivity and species richness has generated intense debate in ecology about the processes regulating local diversity. The original view, which is still widely accepted, holds that the relationship is hump-shaped, with richness first rising and then declining with increasing productivity. Although recent meta-analyses questioned the generality of hump-shaped patterns, these syntheses have been criticized for failing to account for methodological differences among studies. We addressed such concerns by conducting standardized sampling in 48 herbaceous-dominated plant communities on five continents. We found no clear relationship between productivity and fine-scale (meters(-2)) richness within sites, within regions, or across the globe. Ecologists should focus on fresh, mechanistic approaches to understanding the multivariate links between productivity and richness.  相似文献   

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia     

Bhowmick NA  Chytil A  Plieth D  Gorska AE  Dumont N  Shappell S  Washington MK  Neilson EG  Moses HL 《Science (New York, N.Y.)》2004,303(5659):848-851

Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-beta (TGF-beta) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-beta type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-beta responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an increased abundance of stromal cells. Activation of paracrine hepatocyte growth factor (HGF) signaling was identified as one possible mechanism for stimulation of epithelial proliferation. Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues.  相似文献   

Structure of the rotor ring of F-Type Na+-ATPase from Ilyobacter tartaricus     

Meier T  Polzer P  Diederichs K  Welte W  Dimroth P 《Science (New York, N.Y.)》2005,308(5722):659-662

In the crystal structure of the membrane-embedded rotor ring of the sodium ion-translocating adenosine 5'-triphosphate (ATP) synthase of Ilyobacter tartaricus at 2.4 angstrom resolution, 11 c subunits are assembled into an hourglass-shaped cylinder with 11-fold symmetry. Sodium ions are bound in a locked conformation close to the outer surface of the cylinder near the middle of the membrane. The structure supports an ion-translocation mechanism in the intact ATP synthase in which the binding site converts from the locked conformation into one that opens toward subunit a as the rotor ring moves through the subunit a/c interface.  相似文献