Pulmonary vascular pressures of thoroughbred horses exercised 1, 2, 3 and 4 h after furosemide administration     

Magid JH  Manohar M  Goetz TE  Baker GJ  Ulbricht R  Bontkowski S  Ghantous S 《Journal of veterinary pharmacology and therapeutics》2000,23(2):81-89

Furosemide premedication of horses 4 h prior to exercise significantly attenuates exercise-induced pulmonary capillary hypertension which may help diminish the severity of exercise-induced pulmonary haemorrhage. As pulmonary hemodynamic effects of furosemide may be mediated via a reduction in plasma volume (which is most pronounced 15-30 min postfurosemide administration, with plasma volume recovering thereafter), we hypothesized that administration of furosemide at intervals shorter than 4 h before exertion may be more effective in attenuating the exercise-induced rise in pulmonary capillary blood pressure. Thus, our objective was to determine whether furosemide-induced attenuation of exercise-induced pulmonary arterial, capillary and venous hypertension would be enhanced when the drug is administered at intervals shorter than 4 h before exercise. Using established techniques, right atrial, and pulmonary arterial, capillary and wedge (venous) pressures were ascertained in seven healthy, sound, exercise-trained Thoroughbred horses in a randomized split-plot experimental design. Measurements were made at rest and during exercise performed at maximal heart rate (217 +/- 3 beats/min) in the control (no medications) experiments and following furosemide administration (250 mg intravenously (i.v.)) at 1, 2, 3 and 4 h before exercise. Sequence of treatments was randomized and 7 days were allowed between experiments on each horse. Although furosemide administration in the four treatment groups caused only insignificant changes in the pulmonary arterial, capillary and wedge pressures of standing horses, furosemide-induced reduction in mean right atrial pressure achieved statistical significance in the 2 h postfurosemide experiments. In the control studies, exercise was attended by statistically significant increments in mean right atrial, as well as pulmonary arterial, capillary and wedge pressures. Although exercise in each of the four furosemide experiments was also attended by significant increments in right atrial as well as pulmonary vascular pressures, in the 1, 2 and 3 h postfurosemide experiments, mean right atrial pressure increased to a significantly lower value than in the control study. Exercise-induced changes in pulmonary vascular pressures in the 1 h postfurosemide experiments were not different from the pressures in the control study. There was a significant attenuation of exercise-induced pulmonary capillary and venous hypertension in the 2, 3 and 4 h postfurosemide experiments, but significant differences among these treatments were not found. Thus, these data did not support the contention that administration of furosemide at intervals shorter than 4 h before exercise is more effective in attenuating exercise-induced pulmonary capillary or venous hypertension in Thoroughbred horses.  相似文献   

Die Bedeutung der rassischen Ordnung im deutschen Wirtschaftswalde und der Streit um die Aufartung     

H. Goetz 《Forstwissenschaftliches Centralblatt》1937,59(23):725-734

Ohne Zusammenfassung  相似文献   

Cimetidine for treatment of melanomas in three horses   总被引：1，自引：0，他引：1  

T E Goetz  G K Ogilvie  K G Keegan  P J Johnson 《Journal of the American Veterinary Medical Association》1990,196(3):449-452

Cimetidine, an H2 histamine antagonist, was used in the clinical management of progressive, multifocal melanomatosis in 3 adult gray horses. Prior to treatment, the tumors had increased rapidly in size and number in 2 horses (duration of 6 and 27 months, respectively) and slowly in the third horse (duration of 48 months). All 3 horses were treated with cimetidine (2.5 mg/kg of body weight, PO, q 8 h) for 2 months to 1 year. During treatment, the number and size of the melanomas decreased substantially (50 to 90%). The progression of the disease was halted in 2 horses and controlled in the third horse, which is still being treated with cimetidine (1.6 mg/kg, PO, q 24 h). The horses in which treatment was terminated have not been treated for 31 and 41 months, respectively, during which time the melanomas have not increased in number or size.  相似文献   

Migratory routes of short-tailed albatrosses: Use of exclusive economic zones of North Pacific Rim countries and spatial overlap with commercial fisheries in Alaska     

Robert M. Suryan  Kimberly S. Dietrich 《Biological conservation》2007,137(3):450-460

We conducted a satellite tracking study of the endangered short-tailed albatross (Phoebastria albatrus) to determine post-breeding season distribution, the amount of time spent within exclusive economic zones of Pacific Rim countries, and assess factors affecting spatial and temporal overlap with commercial fisheries in Alaska. We obtained 6709 locations for 14 albatrosses (131-808 locations and 51-138 days of tracking per bird). Albatrosses ranged widely throughout the North Pacific Rim, spending the majority of time within the exclusive economics zones of Japan, Russia (Kuril Islands and Kamchatka Peninsula), and the United States (Aleutian Islands and Bering Sea, Alaska). We found evidence for gender and age-related differences in distribution and, therefore, potential interaction with regional fisheries. Overall, albatrosses spent the greatest proportion of time within the Alaska exclusive economic zone. Within Alaska, albatrosses occurred most frequently in fishery management zones that encompassed the Aleutian Islands, Bering Sea, and south of the Alaska Peninsula. Short-tailed albatrosses had the greatest potential overlap with fisheries that occurred along continental shelf break and slope regions, e.g., longlining for sablefish (Anoplopoma fimbria), where albatrosses occurred most often. Some birds, however, also made frequent excursions onto the extensive Bering Sea shelf, suggesting significant potential for interactions with the large-scale walleye pollock (Theragra chalcogramma) and Pacific cod (Gadus macrocephalus) fisheries. Alaskan longline fishing fleets have been proactive in using seabird deterrent devices, however, our data further emphasize that such efforts beyond the Alaska exclusive economic zone would provide a greater conservation benefit for this species.  相似文献   

Die Bedeutung der rassischen Ordnung im deutschen Wirtschastswalde und der Streit um die Aufartung     

H. Goetz 《Forstwissenschaftliches Centralblatt》1937,59(22):693-703

Ohne Zusammenfassung  相似文献   

Die Bedeutung der rassischen Ordnung im deutschen Wirtschaftswalde und der Streit um die Aufartung     

H. Goetz 《Forstwissenschaftliches Centralblatt》1937,59(21):661-676

Ohne Zusammenfassung  相似文献   

Reticulocytosis in nonanemic dogs: increasing prevalence and potential etiologies          下载免费PDF全文

Kimberly M. Pattullo  Beverly A. Kidney  Susan M. Taylor  Marion L. Jackson 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2015,44(1):26-36

  相似文献   

Bilateral renal dysplasia,hydronephrosis, and hydroureter in a septic neonatal foal     

Rebecca A. Gilday  Chris Wojnarowicz  Kimberly A. Tryon  Katharina L. Lohmann 《The Canadian veterinary journal. La revue veterinaire canadienne》2015,56(3):257-260

A Canadian warmblood foal treated for septic polyarthritis was diagnosed with bilateral congenital renal dysplasia, hydronephrosis, and hydroureter at 2 weeks of age based on abdominal ultrasound and postmortem examination. Intermittent abdominal pain throughout the course of treatment was attributed to hydronephrosis and hydroureter.  相似文献   

Disparities in the availability of fruits and vegetables between racially segregated urban neighbourhoods   总被引：2，自引：0，他引：2  

Morland K  Filomena S 《Public health nutrition》2007,10(12):1481-1489

OBJECTIVE: Public health professionals continue to see the benefits of fruit and vegetable consumption on population health. While studies that evaluate the availability of produce are sparse in the medical literature, disparities in availability may explain the disproportional intake of produce for some people. Therefore, the purpose of this study was to evaluate the availability and variety of produce located in two racially and economically diverse urban neighbourhoods. DESIGN: A cross-sectional study was conducted in which 50% of the supermarkets, small grocery stores, delicatessens, and fruit and vegetable markets located in specific neighbourhoods were randomly sampled and surveyed between September 2004 and July 2005. Food stores were evaluated for the availability of 20 types of fresh fruits and 19 types of fresh vegetables, as well as their varieties and whether they were canned, frozen or previously prepared. 2000 US Census information was used to determine characteristics of the geo-coded census tracts where the food stores were located. SETTING: Brooklyn, New York. RESULTS: A supermarket was located in approximately every third census tract in predominantly white areas (prevalence = 0.33) and every fourth census tract in racially mixed areas (prevalence = 0.27). There were no supermarkets located in the predominantly black areas. With the exception of bananas, potatoes, okra and yucca, a lower proportion of predominantly black area stores carried fresh produce, while supermarkets carried the largest variety of produce types. Canned and frozen fruits and vegetables were found in the majority of stores, whereas prepared and organic produce was limited to predominantly white area stores. CONCLUSIONS: These data demonstrate that the availability and variety of fresh produce is associated with neighbourhood racial composition and may be a factor contributing to differences in intake among residents.  相似文献   

Hormonal changes during meiotic maturation and ovulation in the brook trout (Salvelinus fontinalis)     

Frederick W. Goetz  Alexis Y. Fostier  Bernard Breton  Bernard Jalabert 《Fish physiology and biochemistry》1987,3(4):203-211

The plasma levels of estradiol-17 (E2), 17, 20-dihydroxy-4-pregnen-3-one (17,20-P) and gonadotropin (GTH) were measured in brook trout (Salvelinus fontinalis) during the period from the end of vitellogenesis to postovulation. Blood samples were taken according to specific stages of maturation, including germinal vesicle breakdown (GVBD) and ovulation. E2 levels were quite high (45 ng/ml) at the end of vitellogenesis (and prior to GVBD) and dropped precipitously by GVBD (2 ng/ml). They remained low through ovulation and postovulation. 17,20-P levels were low prior to GVBD (0.7 ng/ml) and increased dramatically at GVBD (148 ng/ml). The levels of 17,20-P remained high at ovulation (142 ng/ml) and then dropped significantly within 24 h to approximately half of the ovulatory values. They decreased even further by 7 days postovulation. GTH levels rose gradually through GVBD and ovulation from a postvitellogenic level of approximately 3 ng/ml to a 7 day postovulatory value of approximately 10 ng/ml. The overall results; 1) decrease in estradiol prior to GVBD, 2) increase in 17,20-P at GVBD and 3) gradual GTH rise through GVBD and ovulation, are similar to those reported for other salmonids.  相似文献