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51.
Roditakis Emmanouil Vasakis Emmanouil Grispou Maria Stavrakaki Marianna Nauen Ralf Gravouil Magali Bassi Andrea 《Journal of pest science》2015,88(1):9-16
Journal of Pest Science - The tomato borer Tuta absoluta (Lepidoptera: Gelechiidae) is an invasive pest of tomato crops that is rapidly expanding around the world. It is considered a devastating... 相似文献
52.
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity 总被引：1，自引：0，他引：1
Puel A Cypowyj S Bustamante J Wright JF Liu L Lim HK Migaud M Israel L Chrabieh M Audry M Gumbleton M Toulon A Bodemer C El-Baghdadi J Whitters M Paradis T Brooks J Collins M Wolfman NM Al-Muhsen S Galicchio M Abel L Picard C Casanova JL 《Science (New York, N.Y.)》2011,332(6025):65-68
Chronic mucocutaneous candidiasis disease (CMCD) is characterized by recurrent or persistent infections of the skin, nails, and oral and genital mucosae caused by Candida albicans and, to a lesser extent, Staphylococcus aureus, in patients with no other infectious or autoimmune manifestations. We report two genetic etiologies of CMCD: autosomal recessive deficiency in the cytokine receptor, interleukin-17 receptor A (IL-17RA), and autosomal dominant deficiency of the cytokine interleukin-17F (IL-17F). IL-17RA deficiency is complete, abolishing cellular responses to IL-17A and IL-17F homo- and heterodimers. By contrast, IL-17F deficiency is partial, with mutant IL-17F-containing homo- and heterodimers displaying impaired, but not abolished, activity. These experiments of nature indicate that human IL-17A and IL-17F are essential for mucocutaneous immunity against C. albicans, but otherwise largely redundant. 相似文献
53.
Magali Rault Batrice Collange Christophe Mazzia Yvan Capowiez 《Soil biology & biochemistry》2008,40(12):3086-3091
In order for cholinesterase (ChE) activity to be used as an effective biomarker in earthworms, the time course of enzyme activity inhibition and recovery must be fully characterized. A laboratory experiment was carried out using parathion as a model organophosphorus pesticide at the recommended dose (1 mg kg−1) and a 10 fold higher dose (10 mg kg−1), on two earthworm species (Allolobophora chlorotica and Aporrectodea caliginosa). ChE activity and weight were measured every week for a 14 day period of exposure to parathion and then for 8 weeks in uncontaminated soil. After 3 days of exposure, the weight of both earthworm species had decreased by 10–15% compared to the control, regardless of the dose used. During the remainder of the exposure period, no differences were observed between the two doses for A. chlorotica; but A. caliginosa showed rapid weight recuperation for the lowest dose applied. After 28 days and over, the control and both exposed species of worms lost similar amounts of weight. ChE inhibition was measured during and after the exposure period. ChE inhibition followed a different time course for the two species investigated. A. chlorotica appeared less sensitive to parathion than A. caliginosa. In this latter species, ChE inhibition was rapid at close to 70% of the control after 3 days, for either dose, and reached 80–90% after 7 days exposure. While A. chlorotica exhibited the same pattern of inhibition for 10 mg kg−1 of parathion, the inhibition process was slower for the recommended dose with 50% inhibition after 7 days of exposure and 70% after 14 days. ChE activity recovery, after transfer to uncontaminated soil, also followed a different pattern for the two species. After exposure to 1 mg kg−1 parathion, ChE activity from A. chlorotica underwent a slow but constant recovery process to regain the control value after 8 weeks in unpolluted conditions. On the other hand, the ChE activity from A. caliginosa remained strongly inhibited. The differential susceptibility to parathion found in this study could be related to differences in the specificity of the total ChE activities between those two species. 相似文献